New spinosin derivatives from the seeds of Ziziphus mauritiana

doi:10.1007/s13659-013-0028-5

Natural Products and Bioprospecting ›› 2013, Vol. 3 ›› Issue (3): 93-98.DOI: 10.1007/s13659-013-0028-5

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New spinosin derivatives from the seeds of Ziziphus mauritiana

Bin WANG^a,b, Hong-Tao ZHU^a, Dong WANG^a, Chong-Ren YANG^a, Min XU^a, Ying-Jun ZHANG^a

a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
b University of Chinese Academy of Sciences, Beijing 100049, China

Received:2013-03-28 Revised:2013-04-16 Online:2018-02-11 Published:2013-06-24
Supported by:
We are grateful to the members of the analytical group of our institute for the measurement of spectroscopic data. The authors are sincerely grateful to Prof. Huai-Rong Luo for the AChE inhibitory activity bioassay. This work was supported by the 973 Program of Science and Technology of China (2011CB915503) and the Fourteenth Candidates of the Young Academic Leaders of Yunnan Province (Min Xu, 2011CI044).

New spinosin derivatives from the seeds of Ziziphus mauritiana

Bin WANG^a,b, Hong-Tao ZHU^a, Dong WANG^a, Chong-Ren YANG^a, Min XU^a, Ying-Jun ZHANG^a

a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
b University of Chinese Academy of Sciences, Beijing 100049, China

通讯作者: Ying-Jun ZHANG,E-mail:zhangyj@mail.kib.ac.cn;Min XU,E-mail:xumin@mail.kib.ac.cn
基金资助:
We are grateful to the members of the analytical group of our institute for the measurement of spectroscopic data. The authors are sincerely grateful to Prof. Huai-Rong Luo for the AChE inhibitory activity bioassay. This work was supported by the 973 Program of Science and Technology of China (2011CB915503) and the Fourteenth Candidates of the Young Academic Leaders of Yunnan Province (Min Xu, 2011CI044).

Abstract

Abstract: Three new acylated flavonoid C-glycosides, 6'''-(-)-phaseoylspinosin (1), 6'''-(3"",4"",5""-trimethoxyl)-(E)-cinnamoylspinosin (2), and 6'''-(4""-O-β-D-gluco-pyranosyl)-benzoylspinosin (3), were isolated from the seeds of Ziziphus mauritiana (Rhamnaceae). A further 19 known compounds including eight spinosin analogues (4-11) were also isolated. Their structures were elucidated by means of spectroscopic analysis and chemical method. Among spinosin derivatives 1, 2, 4, 7, 8, and triterpenoid saponin 14, jujuboside A (14) displayed moderate acetylcholinesterase (AchE) inhibitory activity with an inhibition value of 46.2% at a concentration of 1 μM.

Key words: Ziziphus mauritiana, Rhamnaceae, seeds, spinosin derivatives, jujuboside A, acetylcholinesterase inhibitory

摘要： Three new acylated flavonoid C-glycosides, 6'''-(-)-phaseoylspinosin (1), 6'''-(3"",4"",5""-trimethoxyl)-(E)-cinnamoylspinosin (2), and 6'''-(4""-O-β-D-gluco-pyranosyl)-benzoylspinosin (3), were isolated from the seeds of Ziziphus mauritiana (Rhamnaceae). A further 19 known compounds including eight spinosin analogues (4-11) were also isolated. Their structures were elucidated by means of spectroscopic analysis and chemical method. Among spinosin derivatives 1, 2, 4, 7, 8, and triterpenoid saponin 14, jujuboside A (14) displayed moderate acetylcholinesterase (AchE) inhibitory activity with an inhibition value of 46.2% at a concentration of 1 μM.

关键词: Ziziphus mauritiana, Rhamnaceae, seeds, spinosin derivatives, jujuboside A, acetylcholinesterase inhibitory

Bin WANG, Hong-Tao ZHU, Dong WANG, Chong-Ren YANG, Min XU, Ying-Jun ZHANG. New spinosin derivatives from the seeds of Ziziphus mauritiana[J]. Natural Products and Bioprospecting, 2013, 3(3): 93-98.

Bin WANG, Hong-Tao ZHU, Dong WANG, Chong-Ren YANG, Min XU, Ying-Jun ZHANG. New spinosin derivatives from the seeds of Ziziphus mauritiana[J]. 应用天然产物, 2013, 3(3): 93-98.

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New spinosin derivatives from the seeds of Ziziphus mauritiana

New spinosin derivatives from the seeds of Ziziphus mauritiana

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