One-step synthesis of Lycopodium alkaloid(-)-huperzine W via Suzuki-Miyaura coupling

doi:10.1007/s13659-012-0084-2

Natural Products and Bioprospecting ›› 2012, Vol. 2 ›› Issue (6): 255-257.DOI: 10.1007/s13659-012-0084-2

• Short Communication • Previous Articles

One-step synthesis of Lycopodium alkaloid(-)-huperzine W via Suzuki-Miyaura coupling

Tao XU^a,b, Shi-Zhi JIANG^a, Huai-Rong LUO^a, Yu-Rong YANG^a

a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
b University of Chinese Academy of Sciences, Beijing 100049, China

Received:2012-10-19 Revised:2012-11-09 Online:2018-02-11 Published:2012-12-24
Supported by:
We would like to thank the National Natural Science of China(No. 20802084, 21072200), Programs of "One Hundred Talented People" and "Western Light" Joint Scholar of Chinese Academy of Sciences for financial support.

One-step synthesis of Lycopodium alkaloid(-)-huperzine W via Suzuki-Miyaura coupling

Tao XU^a,b, Shi-Zhi JIANG^a, Huai-Rong LUO^a, Yu-Rong YANG^a

a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
b University of Chinese Academy of Sciences, Beijing 100049, China

通讯作者: Yu-Rong YANG,E-mail:yangyurong@mail.kib.ac.cn
基金资助:
We would like to thank the National Natural Science of China(No. 20802084, 21072200), Programs of "One Hundred Talented People" and "Western Light" Joint Scholar of Chinese Academy of Sciences for financial support.

Abstract

Abstract: The first total synthesis of(-)-huperzine W(1) has been achieved. Key element of the synthesis is a highly convergent assemblage for the two rings system of target molecule utilizing an efficient Suzuki-Miyaura coupling reaction between chiral iodide 2 and 2-allylpyrrolidinone 4. Evaluation of the AchE inhibition of synthetic huperzine W was also carried out.

Key words: total synthesis, huperzine W, Lycopodium alkaloids

摘要： The first total synthesis of(-)-huperzine W(1) has been achieved. Key element of the synthesis is a highly convergent assemblage for the two rings system of target molecule utilizing an efficient Suzuki-Miyaura coupling reaction between chiral iodide 2 and 2-allylpyrrolidinone 4. Evaluation of the AchE inhibition of synthetic huperzine W was also carried out.

关键词: total synthesis, huperzine W, Lycopodium alkaloids

Tao XU, Shi-Zhi JIANG, Huai-Rong LUO, Yu-Rong YANG. One-step synthesis of Lycopodium alkaloid(-)-huperzine W via Suzuki-Miyaura coupling[J]. Natural Products and Bioprospecting, 2012, 2(6): 255-257.

Tao XU, Shi-Zhi JIANG, Huai-Rong LUO, Yu-Rong YANG. One-step synthesis of Lycopodium alkaloid(-)-huperzine W via Suzuki-Miyaura coupling[J]. 应用天然产物, 2012, 2(6): 255-257.

References

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One-step synthesis of Lycopodium alkaloid(-)-huperzine W via Suzuki-Miyaura coupling

One-step synthesis of Lycopodium alkaloid(-)-huperzine W via Suzuki-Miyaura coupling

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