Norsesquiterpenoids from the leaves of Croton tiglium

doi:10.1007/s13659-011-0035-3

Natural Products and Bioprospecting ›› 2011, Vol. 1 ›› Issue (3): 134-137.DOI: 10.1007/s13659-011-0035-3

• Short Communication • Previous Articles

Norsesquiterpenoids from the leaves of Croton tiglium

Wei BU^a,c, Yan-Ni SHI^a,b, Yong-Ming YAN^a, Qing LU^a, Guang-Ming LIU^c, Yan LI^a, Yong-Xian CHENG^a

a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
b Graduate University of Chinese Academy of Sciences, Beijing 100049, China;
c Faculty of Pharmacy, Dali University, Dali 671000, China

Received:2011-11-21 Revised:2011-12-14 Online:2018-02-11 Published:2011-06-24
Supported by:
This work was supported by grants(20925205, 21062026, 2010GA014 and 2009CB522300) from National Natural Science Foundation of China, Yunnan Province and National Basic Research Program of China(973 Program).

Norsesquiterpenoids from the leaves of Croton tiglium

Wei BU^a,c, Yan-Ni SHI^a,b, Yong-Ming YAN^a, Qing LU^a, Guang-Ming LIU^c, Yan LI^a, Yong-Xian CHENG^a

a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
b Graduate University of Chinese Academy of Sciences, Beijing 100049, China;
c Faculty of Pharmacy, Dali University, Dali 671000, China

通讯作者: Yong-Xian CHENG,E-mail:yxcheng@mail.kib.ac.cn
基金资助:
This work was supported by grants(20925205, 21062026, 2010GA014 and 2009CB522300) from National Natural Science Foundation of China, Yunnan Province and National Basic Research Program of China(973 Program).

Abstract

Abstract: Two new compounds, badounoids A(1) and B(2), together with 13 known norsesquiterpenes, were isolated from the leaves of Croton tiglium L. The structures of the new compounds were established by means of spectroscopic methods. The absolute configuration of badounoid B was determined by single-crystal X-ray diffraction analysis. All the known compounds were isolated from Croton plants for the first time which added a new chemical facet for this genus. The selected compounds were evaluated for their cytostatic activity against several cancer cell lines. None of them was found to be active.

Key words: Croton tiglium, badounoid, norsesquiterpenoid, cytostatic activity

摘要： Two new compounds, badounoids A(1) and B(2), together with 13 known norsesquiterpenes, were isolated from the leaves of Croton tiglium L. The structures of the new compounds were established by means of spectroscopic methods. The absolute configuration of badounoid B was determined by single-crystal X-ray diffraction analysis. All the known compounds were isolated from Croton plants for the first time which added a new chemical facet for this genus. The selected compounds were evaluated for their cytostatic activity against several cancer cell lines. None of them was found to be active.

关键词: Croton tiglium, badounoid, norsesquiterpenoid, cytostatic activity

Wei BU, Yan-Ni SHI, Yong-Ming YAN, Qing LU, Guang-Ming LIU, Yan LI, Yong-Xian CHENG. Norsesquiterpenoids from the leaves of Croton tiglium[J]. Natural Products and Bioprospecting, 2011, 1(3): 134-137.

Wei BU, Yan-Ni SHI, Yong-Ming YAN, Qing LU, Guang-Ming LIU, Yan LI, Yong-Xian CHENG. Norsesquiterpenoids from the leaves of Croton tiglium[J]. 应用天然产物, 2011, 1(3): 134-137.

Norsesquiterpenoids from the leaves of Croton tiglium

Norsesquiterpenoids from the leaves of Croton tiglium

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