Asprecosides A-J, ten new pentacyclic triterpenoid glycosides with cytotoxic activity from the roots of Ilex asprella

doi:10.1007/s13659-025-00499-7

应用天然产物 ›› 2025, Vol. 15 ›› Issue (2): 18-18.DOI: 10.1007/s13659-025-00499-7

• ORIGINAL ARTICLES • 上一篇下一篇

Asprecosides A-J, ten new pentacyclic triterpenoid glycosides with cytotoxic activity from the roots of Ilex asprella

Yuwei Wu^1,2, Baihui Zhang^1,2, Wenxian Li², Lihua Peng³, Weilin Qiao³, Wei Li^1,2, De-an Guo^1,2

1. School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, People's Republic of China;
2. Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan, 528400, People's Republic of China;
3. Zhongshan Zhongzhi Pharmaceutical Group Co. Ltd., Zhongshan, 528400, People's Republic of China

收稿日期:2025-01-02 接受日期:2025-02-18 出版日期:2025-04-25 发布日期:2025-05-17
通讯作者: Wei Li, E-mail:liwei1@simm.ac.cn;De-an Guo, E-mail:daguo@simm.ac.cn
基金资助:
This work was supported by the Qi-Huang Chief Scientist Project of the National Administration of Traditional Chinese Medicine (2020).

Asprecosides A-J, ten new pentacyclic triterpenoid glycosides with cytotoxic activity from the roots of Ilex asprella

Yuwei Wu^1,2, Baihui Zhang^1,2, Wenxian Li², Lihua Peng³, Weilin Qiao³, Wei Li^1,2, De-an Guo^1,2

1. School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, People's Republic of China;
2. Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan, 528400, People's Republic of China;
3. Zhongshan Zhongzhi Pharmaceutical Group Co. Ltd., Zhongshan, 528400, People's Republic of China

Received:2025-01-02 Accepted:2025-02-18 Online:2025-04-25 Published:2025-05-17
Contact: Wei Li, E-mail:liwei1@simm.ac.cn;De-an Guo, E-mail:daguo@simm.ac.cn
Supported by:
This work was supported by the Qi-Huang Chief Scientist Project of the National Administration of Traditional Chinese Medicine (2020).

摘要/Abstract

摘要： Phytochemical study of the n-BuOH extract of Ilex asprella resulted in the discovery of ten new pentacyclic triterpenoid glycosides, comprising nine ursane-type glycosides (1-9) and one oleanane-type glycoside (10), along with seven known compounds (11-17). Compound 1 is the first reported 19,22-epoxy ursane triterpenoid glycoside, whereas 4 and 5 are rare examples of ursane triterpenoid glycosides containing a 28,19-lactone group. The structural characterization of these compounds was achieved using spectroscopic and chemical techniques, as well as single-crystal X-ray analysis. Compounds 7, 12, 15, and 17 exhibited moderate cytotoxic activities against H1975 and HCC827 cancer cells.

关键词: Ilex asprella, Pentacyclic triterpenoid glycoside, Ursane, Oleanane, Cytotoxic activity

Abstract: Phytochemical study of the n-BuOH extract of Ilex asprella resulted in the discovery of ten new pentacyclic triterpenoid glycosides, comprising nine ursane-type glycosides (1-9) and one oleanane-type glycoside (10), along with seven known compounds (11-17). Compound 1 is the first reported 19,22-epoxy ursane triterpenoid glycoside, whereas 4 and 5 are rare examples of ursane triterpenoid glycosides containing a 28,19-lactone group. The structural characterization of these compounds was achieved using spectroscopic and chemical techniques, as well as single-crystal X-ray analysis. Compounds 7, 12, 15, and 17 exhibited moderate cytotoxic activities against H1975 and HCC827 cancer cells.

Key words: Ilex asprella, Pentacyclic triterpenoid glycoside, Ursane, Oleanane, Cytotoxic activity

Yuwei Wu, Baihui Zhang, Wenxian Li, Lihua Peng, Weilin Qiao, Wei Li, De-an Guo. Asprecosides A-J, ten new pentacyclic triterpenoid glycosides with cytotoxic activity from the roots of Ilex asprella[J]. 应用天然产物, 2025, 15(2): 18-18.

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Asprecosides A-J, ten new pentacyclic triterpenoid glycosides with cytotoxic activity from the roots of Ilex asprella

Asprecosides A-J, ten new pentacyclic triterpenoid glycosides with cytotoxic activity from the roots of Ilex asprella

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