Artemyrianosins A–J, cytotoxic germacrane-type sesquiterpene lactones from Artemisia myriantha

doi:10.1007/s13659-022-00340-5

应用天然产物 ›› 2022, Vol. 12 ›› Issue (3): 16-16.DOI: 10.1007/s13659-022-00340-5

Artemyrianosins A–J, cytotoxic germacrane-type sesquiterpene lactones from Artemisia myriantha

Xin Zhang^1,2, Yun-Bao Ma¹, Xiao-Feng He¹, Tian-Ze Li¹, Chang-An Geng¹, Li-Hua Su¹, Shuang Tang¹, Zhen Gao^1,2, Ji-Jun Chen^1,2

1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, 132# Lanhei Road, Kunming, 650201, Yunnan, People's Republic of China;
2 University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China

收稿日期:2022-03-04 出版日期:2022-06-24 发布日期:2022-06-24
通讯作者: Ji-Jun Chen,E-mail:chenjj@mail.kib.ac.cn
基金资助:
This work was supported by the Key Program of the National Natural Science Foundation of China (22137008) and the Yunnan Wanren Project (YNWR-KJLJ-2019-002).

Artemyrianosins A–J, cytotoxic germacrane-type sesquiterpene lactones from Artemisia myriantha

Xin Zhang^1,2, Yun-Bao Ma¹, Xiao-Feng He¹, Tian-Ze Li¹, Chang-An Geng¹, Li-Hua Su¹, Shuang Tang¹, Zhen Gao^1,2, Ji-Jun Chen^1,2

1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, 132# Lanhei Road, Kunming, 650201, Yunnan, People's Republic of China;
2 University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China

Received:2022-03-04 Online:2022-06-24 Published:2022-06-24
Contact: Ji-Jun Chen,E-mail:chenjj@mail.kib.ac.cn
Supported by:
This work was supported by the Key Program of the National Natural Science Foundation of China (22137008) and the Yunnan Wanren Project (YNWR-KJLJ-2019-002).

摘要/Abstract

摘要： Ten new germacrane-type sesquiterpenoids, artemyrianosins A–J (1–10), were isolated from the aerial parts of Artemisia myriantha. Their structures were elucidated by spectral analyses including UV, IR, HRESIMS, 1D and 2D NMR, ECD and the absolute configurations of compounds 1 and 7–9 were characterized using X-ray crystallography. All isolates were tested their cytotoxicity against three human hepatoma cell lines (HepG2, Huh7, and SK-Hep-1), and compounds 1–3, 7, and 10 showed cytotoxicity with IC₅₀ values ranging from 43.7 to 89.3 μM. Among them, the most active compound 3 exhibited activity against three human hepatoma cell lines with IC₅₀ values of 43.7 μM (HepG2), 47.9 μM (Huh7), and 44.9 μM (SK-Hep-1).

关键词: Artemisia myriantha, Artemyrianosins A–J, Germacrane-type sesquiterpenoids, Cytotoxicity

Abstract: Ten new germacrane-type sesquiterpenoids, artemyrianosins A–J (1–10), were isolated from the aerial parts of Artemisia myriantha. Their structures were elucidated by spectral analyses including UV, IR, HRESIMS, 1D and 2D NMR, ECD and the absolute configurations of compounds 1 and 7–9 were characterized using X-ray crystallography. All isolates were tested their cytotoxicity against three human hepatoma cell lines (HepG2, Huh7, and SK-Hep-1), and compounds 1–3, 7, and 10 showed cytotoxicity with IC₅₀ values ranging from 43.7 to 89.3 μM. Among them, the most active compound 3 exhibited activity against three human hepatoma cell lines with IC₅₀ values of 43.7 μM (HepG2), 47.9 μM (Huh7), and 44.9 μM (SK-Hep-1).

Key words: Artemisia myriantha, Artemyrianosins A–J, Germacrane-type sesquiterpenoids, Cytotoxicity

Xin Zhang, Yun-Bao Ma, Xiao-Feng He, Tian-Ze Li, Chang-An Geng, Li-Hua Su, Shuang Tang, Zhen Gao, Ji-Jun Chen. Artemyrianosins A–J, cytotoxic germacrane-type sesquiterpene lactones from Artemisia myriantha[J]. 应用天然产物, 2022, 12(3): 16-16.

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Artemyrianosins A–J, cytotoxic germacrane-type sesquiterpene lactones from Artemisia myriantha

Artemyrianosins A–J, cytotoxic germacrane-type sesquiterpene lactones from Artemisia myriantha

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