整合生物学期刊网

应用天然产物 ›› 2021, Vol. 11 ›› Issue (2): 207-213.DOI: 10.1007/s13659-020-00278-6

• ORIGINAL ARTICLES • 上一篇    下一篇

Bousmekines A-E, New Alkaloids from Two Bousigonia Species: B.angustifolia and B. mekongensis

Zong-Qing Huo, Qian Zhao, Wen-Tao Zhu, Xiao-Jiang Hao, Yu Zhang   

  1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China
  • 收稿日期:2020-10-13 修回日期:2020-10-26 出版日期:2021-04-24 发布日期:2021-04-07
  • 通讯作者: Yu Zhang
  • 基金资助:
    This work was financially supported by Yunnan Applied Basic Research Projects (2018FA049) and Top Young Talent of the Ten Thousand Talents Program of Yunnan (to Y. Zhang).

Bousmekines A-E, New Alkaloids from Two Bousigonia Species: B.angustifolia and B. mekongensis

Zong-Qing Huo, Qian Zhao, Wen-Tao Zhu, Xiao-Jiang Hao, Yu Zhang   

  1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China
  • Received:2020-10-13 Revised:2020-10-26 Online:2021-04-24 Published:2021-04-07
  • Contact: Yu Zhang
  • Supported by:
    This work was financially supported by Yunnan Applied Basic Research Projects (2018FA049) and Top Young Talent of the Ten Thousand Talents Program of Yunnan (to Y. Zhang).

PDF (PC)

10300

摘要： Four new monoterpenoid indole alkaloids, bousmekines A-D (1-4), and one new pyranopyridine alkaloid, bousmekine E (5), were isolated from the twigs and leaves of Bousigonia angustifolia and Bousigonia mekongensis. Their structures including absolute configurations were elucidated by a combination of MS, NMR, ECD calculation, and single-crystal X-ray diffraction analysis. Compound 2 was an eburnea-type MIAs characterized by a rare chlorine atom while 5 possessed a novel pyranopyridine moiety. Their cytotoxicities against several human cancer cell lines were evaluated and compound 1 exhibited significant cytotoxicity with IC50 values of 0.8-7.4 μM.

关键词: Bousigonia, B. angustifolia, B. mekongensis, Monoterpenoid indole alkaloids, Bousmekines A-E

Abstract: Four new monoterpenoid indole alkaloids, bousmekines A-D (1-4), and one new pyranopyridine alkaloid, bousmekine E (5), were isolated from the twigs and leaves of Bousigonia angustifolia and Bousigonia mekongensis. Their structures including absolute configurations were elucidated by a combination of MS, NMR, ECD calculation, and single-crystal X-ray diffraction analysis. Compound 2 was an eburnea-type MIAs characterized by a rare chlorine atom while 5 possessed a novel pyranopyridine moiety. Their cytotoxicities against several human cancer cell lines were evaluated and compound 1 exhibited significant cytotoxicity with IC50 values of 0.8-7.4 μM.

Key words: Bousigonia, B. angustifolia, B. mekongensis, Monoterpenoid indole alkaloids, Bousmekines A-E

版权所有 © 《应用天然产物》编辑部
地址：132# Lanhei Road, Heilongtan, Kunming 650201, Yunnan, China　
电话：0871-65223223　
E-mail：npb@mail.kib.ac.cn
技术支持：北京玛格泰克科技发展有限公司