Three New Compounds from the Actinomycete Actinocorallia aurantiaca

doi:10.1007/s13659-019-00217-0

应用天然产物 ›› 2019, Vol. 9 ›› Issue (5): 351-354.DOI: 10.1007/s13659-019-00217-0

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Three New Compounds from the Actinomycete Actinocorallia aurantiaca

Kai-Yue Han¹, Xing Wu¹, Chenglin Jiang², Rong Huang¹, Zheng-Hui Li¹, Tao Feng¹, He-Ping Chen¹, Ji-Kai Liu¹

1 School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, People's Republic of China;
2 State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan Institute of Microbiology, School of Life Sciences, Yunnan University, Kunming 650091, People's Republic of China

收稿日期:2019-08-04 修回日期:2019-09-10 出版日期:2019-10-24 发布日期:2019-10-30
通讯作者: He-Ping Chen, Ji-Kai Liu
基金资助:
This work was financially supported by National Natural Science Foundation of China (Grant No. 81773590). The authors thank Analytical & Measuring Centre, South-Central University for Nationalities, for the NMR measurements.

Three New Compounds from the Actinomycete Actinocorallia aurantiaca

Kai-Yue Han¹, Xing Wu¹, Chenglin Jiang², Rong Huang¹, Zheng-Hui Li¹, Tao Feng¹, He-Ping Chen¹, Ji-Kai Liu¹

1 School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, People's Republic of China;
2 State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan Institute of Microbiology, School of Life Sciences, Yunnan University, Kunming 650091, People's Republic of China

Received:2019-08-04 Revised:2019-09-10 Online:2019-10-24 Published:2019-10-30
Contact: He-Ping Chen, Ji-Kai Liu
Supported by:
This work was financially supported by National Natural Science Foundation of China (Grant No. 81773590). The authors thank Analytical & Measuring Centre, South-Central University for Nationalities, for the NMR measurements.

摘要/Abstract

摘要： Aurantiadioic acids A (1) and B (2), two new furan-containing polyketides, and aurantoic acid A (3), a new natural product, were isolated from the liquid fermentation of the sika deer dung-derived actinomycete Actinocorallia aurantiaca. The structures of the new compounds were established by extensive spectroscopic methods, including 1D & 2D NMR, HRESIMS spectroscopic analysis. The absolute configuration of 3 was assigned by comparison of the specific optical rotations with the reported derivatives. Biological activity evaluations suggested that compounds 1-3 showed weak inhibition on NO production in the murine monocytic RAW 264.7 macrophages with IC₅₀ values of 35.8, 41.8, 45.2 μM, respectively. Compound 3 showed weak inhibition on influenza A virus (A/PuertoRico/8/1934, H1N1) with an EC₅₀ value of 35.9 μM, and a selective index higher than 13.3.

关键词: Actinomycete, Actinocorallia aurantiaca, Polyketides, Anti-NO activity, Antiviral activity

Abstract: Aurantiadioic acids A (1) and B (2), two new furan-containing polyketides, and aurantoic acid A (3), a new natural product, were isolated from the liquid fermentation of the sika deer dung-derived actinomycete Actinocorallia aurantiaca. The structures of the new compounds were established by extensive spectroscopic methods, including 1D & 2D NMR, HRESIMS spectroscopic analysis. The absolute configuration of 3 was assigned by comparison of the specific optical rotations with the reported derivatives. Biological activity evaluations suggested that compounds 1-3 showed weak inhibition on NO production in the murine monocytic RAW 264.7 macrophages with IC₅₀ values of 35.8, 41.8, 45.2 μM, respectively. Compound 3 showed weak inhibition on influenza A virus (A/PuertoRico/8/1934, H1N1) with an EC₅₀ value of 35.9 μM, and a selective index higher than 13.3.

Key words: Actinomycete, Actinocorallia aurantiaca, Polyketides, Anti-NO activity, Antiviral activity

Kai-Yue Han, Xing Wu, Chenglin Jiang, Rong Huang, Zheng-Hui Li, Tao Feng, He-Ping Chen, Ji-Kai Liu. Three New Compounds from the Actinomycete Actinocorallia aurantiaca[J]. 应用天然产物, 2019, 9(5): 351-354.

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Three New Compounds from the Actinomycete Actinocorallia aurantiaca

Three New Compounds from the Actinomycete Actinocorallia aurantiaca

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