Xylanilyticolides A-C, Three New Compounds from Cultures of the Actinomycete Promicromonospora xylanilytica YIM 61515

doi:10.1007/s13659-018-0154-1

应用天然产物 ›› 2018, Vol. 8 ›› Issue (2): 91-95.DOI: 10.1007/s13659-018-0154-1

• ORIGINAL ARTICLES • 上一篇下一篇

Xylanilyticolides A-C, Three New Compounds from Cultures of the Actinomycete Promicromonospora xylanilytica YIM 61515

Zhen-Xiong Wang¹, Shen Qin², Li-Hua Xu², He-Ping Chen¹, Huan Sun¹, Rong Huang¹, Zheng-Hui Li¹, Tao Feng¹, Ji-Kai Liu¹

1 School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China;
2 Yunnan Institute of Microbiology, Yunnan University, Kunming 650091, China

收稿日期:2017-12-27 修回日期:2018-01-19 出版日期:2018-04-24 发布日期:2018-04-26
通讯作者: Tao Feng, Ji-Kai Liu
基金资助:
This work was financially supported by National Natural Science Foundation of China (81561148013, 21502239), the Key Projects of Technological Innovation of Hubei Province (No. 2016ACA138), and the Fundamental Research Funds for the Central University, South-Central University for Nationalities (CZZ17006, CZQ17008). The authors thank Analytical & Measuring Centre, South-Central University for Nationalities, for the NMR measurements.

Xylanilyticolides A-C, Three New Compounds from Cultures of the Actinomycete Promicromonospora xylanilytica YIM 61515

Zhen-Xiong Wang¹, Shen Qin², Li-Hua Xu², He-Ping Chen¹, Huan Sun¹, Rong Huang¹, Zheng-Hui Li¹, Tao Feng¹, Ji-Kai Liu¹

1 School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China;
2 Yunnan Institute of Microbiology, Yunnan University, Kunming 650091, China

Received:2017-12-27 Revised:2018-01-19 Online:2018-04-24 Published:2018-04-26
Contact: Tao Feng, Ji-Kai Liu
Supported by:
This work was financially supported by National Natural Science Foundation of China (81561148013, 21502239), the Key Projects of Technological Innovation of Hubei Province (No. 2016ACA138), and the Fundamental Research Funds for the Central University, South-Central University for Nationalities (CZZ17006, CZQ17008). The authors thank Analytical & Measuring Centre, South-Central University for Nationalities, for the NMR measurements.

摘要/Abstract

摘要： Three new lactones, xylanilyticolides A-C (1-3), were isolated from cultures of the actinomycete Promicromonospora xylanilytica YIM 61515. Their structures were elucidated by 1D and 2D NMR spectroscopic data in conjunction with HRESIMS analysis. Compound 1 exhibited potent cytotoxicities against five human cancer cell lines HL-60, A-549, SMMC-7721, MCF-7 and SW480 with the IC₅₀ values of 3.9, 15.2, 11.2, 5.9, and 4.7 μM, respectively.

关键词: Promicromonospora xylanilytica, Xylanilyticolides, Cytotoxicity, Actinomycete

Abstract: Three new lactones, xylanilyticolides A-C (1-3), were isolated from cultures of the actinomycete Promicromonospora xylanilytica YIM 61515. Their structures were elucidated by 1D and 2D NMR spectroscopic data in conjunction with HRESIMS analysis. Compound 1 exhibited potent cytotoxicities against five human cancer cell lines HL-60, A-549, SMMC-7721, MCF-7 and SW480 with the IC₅₀ values of 3.9, 15.2, 11.2, 5.9, and 4.7 μM, respectively.

Key words: Actinomycete, Promicromonospora xylanilytica, Xylanilyticolides, Cytotoxicity

Zhen-Xiong Wang, Shen Qin, Li-Hua Xu, He-Ping Chen, Huan Sun, Rong Huang, Zheng-Hui Li, Tao Feng, Ji-Kai Liu. Xylanilyticolides A-C, Three New Compounds from Cultures of the Actinomycete Promicromonospora xylanilytica YIM 61515[J]. 应用天然产物, 2018, 8(2): 91-95.

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Xylanilyticolides A-C, Three New Compounds from Cultures of the Actinomycete Promicromonospora xylanilytica YIM 61515

Xylanilyticolides A-C, Three New Compounds from Cultures of the Actinomycete Promicromonospora xylanilytica YIM 61515

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