整合生物学期刊网

应用天然产物 ›› 2014, Vol. 4 ›› Issue (2): 101-105.DOI: 10.1007/s13659-014-0010-x

• Original article • 上一篇    下一篇

Diprenylated Indole Alkaloids from Fruits of Hexalobus monopetalus

Hamisi M. Malebo1, Stephan A. Jonker2, Reiner Waibel3, Mayunga H. H. Nkunya2   

  1. 1. Department of Traditional Medicine Research, National Institute for Medical Research, P. O. Box 9653, Dar es Salaam, Tanzania;
    2. Department of Chemistry, University of Dar es Salaam, P. O. Box 35061, Dar es Salaam, Tanzania;
    3. Department of Pharmaceutical Chemistry, Institute of Pharmacy, University of Erlangen, Schuhstrasse 19, 91052 Erlangen, Germany
  • 收稿日期:2014-02-17 修回日期:2014-03-16 出版日期:2014-04-24 发布日期:2018-02-11
  • 通讯作者: Hamisi M.Malebo,e-mail:Malebo@hotmail.com
  • 基金资助:
    The Norwegian Agency for International Development(NORAD) through the NORAD Chemistry Project is appreciated for supporting this work through a scholarship grant to H. M. M. The National Institute for Medical Research(NIMR), The Department of Chemistry at the University of Dar es Salaam in Tanzania and the Department of Pharmaceutical Chemistry in the Institute of Pharmacy at Erlangen University in Germany are thanked for supporting the research project.

Diprenylated Indole Alkaloids from Fruits of Hexalobus monopetalus

Hamisi M. Malebo1, Stephan A. Jonker2, Reiner Waibel3, Mayunga H. H. Nkunya2   

  1. 1. Department of Traditional Medicine Research, National Institute for Medical Research, P. O. Box 9653, Dar es Salaam, Tanzania;
    2. Department of Chemistry, University of Dar es Salaam, P. O. Box 35061, Dar es Salaam, Tanzania;
    3. Department of Pharmaceutical Chemistry, Institute of Pharmacy, University of Erlangen, Schuhstrasse 19, 91052 Erlangen, Germany
  • Received:2014-02-17 Revised:2014-03-16 Online:2014-04-24 Published:2018-02-11
  • Supported by:
    The Norwegian Agency for International Development(NORAD) through the NORAD Chemistry Project is appreciated for supporting this work through a scholarship grant to H. M. M. The National Institute for Medical Research(NIMR), The Department of Chemistry at the University of Dar es Salaam in Tanzania and the Department of Pharmaceutical Chemistry in the Institute of Pharmacy at Erlangen University in Germany are thanked for supporting the research project.

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摘要： New hexalobine type alkaloid, 5-(2", 3"-epoxy-3"-methylbutyl)-3-(3'-hydroxy-3'-methyl-1'-acetyloxy-but-2'-yl) indole(1) alongside the known hexalobines 3-(2', 3'-dihydroxy-3'-methylbutyl)-5-(3"-methylcrotonoyl) indole(2), 3, 5-hexalobine C(3) and 3, 5-hexalobine D(4) were isolated from fruits of Hexalobus monopetalus. Compounds 3 and 4 exhibited antifungal activity against Candida albicans.

关键词: Hexalobus monopetalus, Hexalobines, Indole alkaloids, Candida albicans

Abstract: New hexalobine type alkaloid, 5-(2", 3"-epoxy-3"-methylbutyl)-3-(3'-hydroxy-3'-methyl-1'-acetyloxy-but-2'-yl) indole(1) alongside the known hexalobines 3-(2', 3'-dihydroxy-3'-methylbutyl)-5-(3"-methylcrotonoyl) indole(2), 3, 5-hexalobine C(3) and 3, 5-hexalobine D(4) were isolated from fruits of Hexalobus monopetalus. Compounds 3 and 4 exhibited antifungal activity against Candida albicans.

Key words: Hexalobus monopetalus, Hexalobines, Indole alkaloids, Candida albicans

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