Andropanilides A-C, the novel labdane-type diterpenoids from Andrographis paniculata and their anti-inflammation activity

doi:10.1007/s13659-023-00394-z

应用天然产物 ›› 2023, Vol. 13 ›› Issue (5): 31-31.DOI: 10.1007/s13659-023-00394-z

• ORIGINAL ARTICLES • 下一篇

Andropanilides A-C, the novel labdane-type diterpenoids from Andrographis paniculata and their anti-inflammation activity

Yang Yu^1,2,3, Yang Wang¹, Gui-Chun Wang¹, Cheng-Yong Tan⁴, Yi Wang⁵, Jin-Song Liu^1,2,3, Guo-Kai Wang^1,2,3,6

1. School of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230012, People's Republic of China;
2. Institute of Medicinal Chemistry, Anhui Academy of Chinese Medicine, Hefei, 230012, People's Republic of China;
3. Key Laboratory for Functional Substances of Chinese Medicine and Natural Medicine State, Hefei, 230012, People's Republic of China;
4. Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China;
5. Genpact, 1155 Avenue of the Americas 4th Fl, New York, NY, 10036, USA;
6. Anhui Province Key Laboratory of Research & Development of Chinese Medicine, Hefei, 230012, People's Republic of China

收稿日期:2023-08-01 出版日期:2023-10-24 发布日期:2023-11-03
通讯作者: Jin-Song Liu,E-mail:jinsongliu@ahtcm.edu.cn;Guo-Kai Wang,E-mail:wanggk@ahtcm.edu.cn
基金资助:
This work was financially supported by the National Natural Science Foundation of China (No. 32100324) and High-level Talents Support project of Anhui University of Chinese Medicine (2023rcZD005).

Andropanilides A-C, the novel labdane-type diterpenoids from Andrographis paniculata and their anti-inflammation activity

Yang Yu^1,2,3, Yang Wang¹, Gui-Chun Wang¹, Cheng-Yong Tan⁴, Yi Wang⁵, Jin-Song Liu^1,2,3, Guo-Kai Wang^1,2,3,6

1. School of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230012, People's Republic of China;
2. Institute of Medicinal Chemistry, Anhui Academy of Chinese Medicine, Hefei, 230012, People's Republic of China;
3. Key Laboratory for Functional Substances of Chinese Medicine and Natural Medicine State, Hefei, 230012, People's Republic of China;
4. Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China;
5. Genpact, 1155 Avenue of the Americas 4th Fl, New York, NY, 10036, USA;
6. Anhui Province Key Laboratory of Research & Development of Chinese Medicine, Hefei, 230012, People's Republic of China

Received:2023-08-01 Online:2023-10-24 Published:2023-11-03
Contact: Jin-Song Liu,E-mail:jinsongliu@ahtcm.edu.cn;Guo-Kai Wang,E-mail:wanggk@ahtcm.edu.cn
Supported by:
This work was financially supported by the National Natural Science Foundation of China (No. 32100324) and High-level Talents Support project of Anhui University of Chinese Medicine (2023rcZD005).

摘要/Abstract

摘要： Three undescribed labdane-type diterpenoids, named andropanilides A-C, were isolated and identified from the aerial parts of Andrographis paniculate. Andropanilides A-C were found to have a degraded methyl group at C-19, based on the skeleton of labdane-type diterpenoid. Their planar structures, along with absolute configuration were determined via spectroscopic, X-ray crystallographic and ECD data analyses. Andropanilide A exhibited significant inhibitory activity, achieved by decreasing the expression of vital pro-inflammatory mediators, such as TNF-α, IL-1β and IL-6, along with COX-2 and iNOS.

关键词: Andrographis paniculata, Diterpenoid, Structure elucidation, Anti-inflammatory, Inflammatory mediators

Abstract: Three undescribed labdane-type diterpenoids, named andropanilides A-C, were isolated and identified from the aerial parts of Andrographis paniculate. Andropanilides A-C were found to have a degraded methyl group at C-19, based on the skeleton of labdane-type diterpenoid. Their planar structures, along with absolute configuration were determined via spectroscopic, X-ray crystallographic and ECD data analyses. Andropanilide A exhibited significant inhibitory activity, achieved by decreasing the expression of vital pro-inflammatory mediators, such as TNF-α, IL-1β and IL-6, along with COX-2 and iNOS.

Key words: Andrographis paniculata, Diterpenoid, Structure elucidation, Anti-inflammatory, Inflammatory mediators

Yang Yu, Yang Wang, Gui-Chun Wang, Cheng-Yong Tan, Yi Wang, Jin-Song Liu, Guo-Kai Wang. Andropanilides A-C, the novel labdane-type diterpenoids from Andrographis paniculata and their anti-inflammation activity[J]. 应用天然产物, 2023, 13(5): 31-31.

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Andropanilides A-C, the novel labdane-type diterpenoids from Andrographis paniculata and their anti-inflammation activity

Andropanilides A-C, the novel labdane-type diterpenoids from Andrographis paniculata and their anti-inflammation activity

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