The medicinal chemistry of Urtica dioica L.: from preliminary evidence to clinical studies supporting its neuroprotective activity

doi:10.1007/s13659-023-00380-5

应用天然产物 ›› 2023, Vol. 13 ›› Issue (3): 16-16.DOI: 10.1007/s13659-023-00380-5

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The medicinal chemistry of Urtica dioica L.: from preliminary evidence to clinical studies supporting its neuroprotective activity

Prabhakar Semwal¹, Abdur Rauf², Ahmed Olatunde³, Pooja Singh¹, Mohamed Y. Zaky^4,5, Md. Mozahidul Islam⁶, Anees Ahmed Khalil⁷, Abdullah S. M. Aljohani⁸, Waleed Al Abdulmonem⁹, Giovanni Ribaudo¹⁰

1. Department of Biotechnology, Graphic Era Deemed to be University, 566/6 Bell Road, Clement Town, Dehra Dun, India;
2. Department of Chemistry, University of Swabi, Swabi, Pakistan;
3. Department of Medical Biochemistry, Abubakar Tafawa Balewa University, Bauchi, Nigeria;
4. Molecular Physiology Division, Faculty of Science, Beni-Suef University, Beni-Suef, Egypt;
5. Oncology Division, Department of Biomedical and Clinical Science, Faculty of Medicine, Linköping University, Linköping, Sweden;
6. Department of Environmental Management, SESM, Independent University, Bangladesh, Bashundhara R/A, Dhaka, Bangladesh;
7. University Institute of Diet and Nutritional Sciences, Faculty of Allied Health Sciences, The University of Lahore, Lahore, Pakistan;
8. Department of Veterinary Medicine, College of Agriculture and Veterinary Medicine, Qassim University, Buraydah, Saudi Arabia;
9. Department of Pathology, College of Medicine, Qassim University, Buraydah, Saudi Arabia;
10. Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy

收稿日期:2023-04-18 出版日期:2023-06-24 发布日期:2023-07-18
通讯作者: Prabhakar Semwal,E-mail:semwal.prabhakar@gmail.com;Abdur Rauf,E-mail:abdurrauf@uoswabi.edu.pk;Giovanni Ribaudo,E-mail:giovanni.ribaudo@unibs.it

The medicinal chemistry of Urtica dioica L.: from preliminary evidence to clinical studies supporting its neuroprotective activity

1. Department of Biotechnology, Graphic Era Deemed to be University, 566/6 Bell Road, Clement Town, Dehra Dun, India;
2. Department of Chemistry, University of Swabi, Swabi, Pakistan;
3. Department of Medical Biochemistry, Abubakar Tafawa Balewa University, Bauchi, Nigeria;
4. Molecular Physiology Division, Faculty of Science, Beni-Suef University, Beni-Suef, Egypt;
5. Oncology Division, Department of Biomedical and Clinical Science, Faculty of Medicine, Linköping University, Linköping, Sweden;
6. Department of Environmental Management, SESM, Independent University, Bangladesh, Bashundhara R/A, Dhaka, Bangladesh;
7. University Institute of Diet and Nutritional Sciences, Faculty of Allied Health Sciences, The University of Lahore, Lahore, Pakistan;
8. Department of Veterinary Medicine, College of Agriculture and Veterinary Medicine, Qassim University, Buraydah, Saudi Arabia;
9. Department of Pathology, College of Medicine, Qassim University, Buraydah, Saudi Arabia;
10. Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy

Received:2023-04-18 Online:2023-06-24 Published:2023-07-18
Contact: Prabhakar Semwal,E-mail:semwal.prabhakar@gmail.com;Abdur Rauf,E-mail:abdurrauf@uoswabi.edu.pk;Giovanni Ribaudo,E-mail:giovanni.ribaudo@unibs.it

摘要/Abstract

摘要： Urtica dioica is a perennial herb from the family of Urticaceae that is commonly known as stinging nettle. This plant is widespread in Europe, Africa, America, and a part of Asia, as it adapts to different environments and climatic conditions. The leaves, stalk, and bark of U. dioica found applications in the field of nutrition, cosmetics, textile, pest control and pharmacology. In this connection, bioactive chemical constituents such as flavonoids, phenolic acids, amino acids, carotenoids, and fatty acids have been isolated from the plant. With this review, we aim at providing an updated and comprehensive overview of the contributions in literature reporting computational, in vitro, pre-clinical and clinical data supporting the therapeutic applications of U. dioica. Experimental evidence shows that U. dioica constituents and extracts can provide neuroprotective effects by acting through a combination of different molecular mechanisms, that are discussed in the review. These findings could lay the basis for the identification and design of more effective tools against neurodegenerative diseases.

关键词: Urtica dioica, Neuroprotection, Natural compounds, Flavonoids, Medicinal chemistry

Abstract: Urtica dioica is a perennial herb from the family of Urticaceae that is commonly known as stinging nettle. This plant is widespread in Europe, Africa, America, and a part of Asia, as it adapts to different environments and climatic conditions. The leaves, stalk, and bark of U. dioica found applications in the field of nutrition, cosmetics, textile, pest control and pharmacology. In this connection, bioactive chemical constituents such as flavonoids, phenolic acids, amino acids, carotenoids, and fatty acids have been isolated from the plant. With this review, we aim at providing an updated and comprehensive overview of the contributions in literature reporting computational, in vitro, pre-clinical and clinical data supporting the therapeutic applications of U. dioica. Experimental evidence shows that U. dioica constituents and extracts can provide neuroprotective effects by acting through a combination of different molecular mechanisms, that are discussed in the review. These findings could lay the basis for the identification and design of more effective tools against neurodegenerative diseases.

Key words: Urtica dioica, Neuroprotection, Natural compounds, Flavonoids, Medicinal chemistry

Prabhakar Semwal, Abdur Rauf, Ahmed Olatunde, Pooja Singh, Mohamed Y. Zaky, Md. Mozahidul Islam, Anees Ahmed Khalil, Abdullah S. M. Aljohani, Waleed Al Abdulmonem, Giovanni Ribaudo. The medicinal chemistry of Urtica dioica L.: from preliminary evidence to clinical studies supporting its neuroprotective activity[J]. 应用天然产物, 2023, 13(3): 16-16.

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The medicinal chemistry of Urtica dioica L.: from preliminary evidence to clinical studies supporting its neuroprotective activity

The medicinal chemistry of Urtica dioica L.: from preliminary evidence to clinical studies supporting its neuroprotective activity

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