A Systemic Review on Topical Marketed Formulations, Natural Products, and Oral Supplements to Prevent Androgenic Alopecia: A Review

doi:10.1007/s13659-020-00267-9

应用天然产物 ›› 2020, Vol. 10 ›› Issue (6): 345-365.DOI: 10.1007/s13659-020-00267-9

• REVIEW • 下一篇

A Systemic Review on Topical Marketed Formulations, Natural Products, and Oral Supplements to Prevent Androgenic Alopecia: A Review

Sumel Ashique¹, Navjot Kaur Sandhu², Sk. Niyamul Haque³, Kartick Koley³

1 Department of Pharmaceutics, ISF College of Pharmacy, Moga, Punjab 142001, India;
2 Department of Quality Assurance and Pharmaceutical Analysis, ISF College of Pharmacy, Moga, Punjab 142001, India;
3 Department of Pharmaceutics, Gurunanak Institute of Pharmaceutical Science and Technology, Kolkata, West Bengal 700110, India

收稿日期:2020-08-02 修回日期:2020-09-18 出版日期:2020-12-24 发布日期:2020-12-24
通讯作者: Navjot Kaur Sandhu
基金资助:
We are highly thankful to the management of ISF College of Pharmacy for continuous support and guidance.

A Systemic Review on Topical Marketed Formulations, Natural Products, and Oral Supplements to Prevent Androgenic Alopecia: A Review

Sumel Ashique¹, Navjot Kaur Sandhu², Sk. Niyamul Haque³, Kartick Koley³

1 Department of Pharmaceutics, ISF College of Pharmacy, Moga, Punjab 142001, India;
2 Department of Quality Assurance and Pharmaceutical Analysis, ISF College of Pharmacy, Moga, Punjab 142001, India;
3 Department of Pharmaceutics, Gurunanak Institute of Pharmaceutical Science and Technology, Kolkata, West Bengal 700110, India

Received:2020-08-02 Revised:2020-09-18 Online:2020-12-24 Published:2020-12-24
Contact: Navjot Kaur Sandhu
Supported by:
We are highly thankful to the management of ISF College of Pharmacy for continuous support and guidance.

摘要/Abstract

摘要： Androgens have an intense consequence on the human scalp and body hair. Scalp hair sprouts fundamentally in awol of androgens whereas the body hair hike is vulnerable to the activity of androgens. Androgenetic alopecia (AGA) invoked as males emulate Alopecia due to the cause of the dynamic reduction of scalp hair. Androgens are medium of terminus growth of hair although the body. Local and system androgens convert the extensive terminal follicles into lesser vellus like structure. The out start of this type of alopecia is intensely irregular and the reason behind this existence of enough circulating steroidal hormones androgens and due to genetic predisposition. Effective treatments are available in the market as well as under clinical and preclinical testing. Many herbal formulations are also available but not FDA approved. Different conventional and NDDS formulations are already available in the market. To avoid various systemic side effects of both Finasteride and Minoxidil, topical formulations and natural products (nutrients, minerals, vitamins) now a days are being widely used to treat Androgenic alopecia. CAM (complementary and alternative medicine) provides the option to elect favorable, low-risk, adjuvant and alternative therapies. Herein, we offer a widespread review of topical marketed formulations, natural products, and CAM treatment options for AGA.

关键词: Androgenetic alopecia, FDA approved drugs, Natural products, Herbal and novel topical marketed formulations, Brief descriptions about formulations, Formulation under clinical trials

Abstract: Androgens have an intense consequence on the human scalp and body hair. Scalp hair sprouts fundamentally in awol of androgens whereas the body hair hike is vulnerable to the activity of androgens. Androgenetic alopecia (AGA) invoked as males emulate Alopecia due to the cause of the dynamic reduction of scalp hair. Androgens are medium of terminus growth of hair although the body. Local and system androgens convert the extensive terminal follicles into lesser vellus like structure. The out start of this type of alopecia is intensely irregular and the reason behind this existence of enough circulating steroidal hormones androgens and due to genetic predisposition. Effective treatments are available in the market as well as under clinical and preclinical testing. Many herbal formulations are also available but not FDA approved. Different conventional and NDDS formulations are already available in the market. To avoid various systemic side effects of both Finasteride and Minoxidil, topical formulations and natural products (nutrients, minerals, vitamins) now a days are being widely used to treat Androgenic alopecia. CAM (complementary and alternative medicine) provides the option to elect favorable, low-risk, adjuvant and alternative therapies. Herein, we offer a widespread review of topical marketed formulations, natural products, and CAM treatment options for AGA.

Key words: Androgenetic alopecia, FDA approved drugs, Natural products, Herbal and novel topical marketed formulations, Brief descriptions about formulations, Formulation under clinical trials

Sumel Ashique, Navjot Kaur Sandhu, Sk. Niyamul Haque, Kartick Koley. A Systemic Review on Topical Marketed Formulations, Natural Products, and Oral Supplements to Prevent Androgenic Alopecia: A Review[J]. 应用天然产物, 2020, 10(6): 345-365.

参考文献

1. E.P. Jenkins, S. Andersson, J. Imperato-McGinley, J.D. Wilson, D.W. Russell, J. Clin. Investig. 89, 293-300 (1992)
2. W. Eicheler, M. Dreher, R. Hoffmann, R. Happle, G. Aumüller, Br. J. Dermatol. 133, 371-376 (1995)
3. O.A. Jänne, J.J. Palvimo, P. Kallio, M. Mehto, Ann. Med. 25, 83-89 (1993)
4. M.J. McPhaul, M. Young, J. Am. Acad. Dermatol. 45, S87-S94 (2001)
5. H.U. Schweikert, J.D. Wilson, J. Clin. Endocrinol. Metab. 38, 811-819 (1974)
6. A.L. Dallob, N.S. Sadick, W. Unger, S. Lipert, L.A. Geissler, S.L. Gregoire, H.H. Nguyen, E.C. Moore, W.K. Tanaka, J. Clin. Endocrinol. Metab. 79, 703-706 (1994)
7. A. Herman, A.P. Herman, Arch. Dermatol. Res. 309, 595-610 (2017)
8. N. Smith, D.B. Shin, J.A. Brauer, J. Mao, J.M. Gelfand, J. Am. Acad. Dermatol. 60, 419-425 (2009)
9. https://www.nytimes.com/2014/09/20/business/guinter-kahninventor-of-baldness-remedy-dies-at-80. Accessed 25 Feb 2020
10. P. Conrad, Sociol. Health Illn. 31, 147-148 (2009)
11. W. Lester, Daily Gaz. (2015)
12. W.S. Pray, Am. J. Pharm. Educ. 70, 94-97 (2006)
13. S. Varothai, W.F. Bergfeld, Am. J. Clin. Dermatol. 15, 217-230 (2014)
14. M.C. Jones, US Pharm. 43, 12-16 (2018)
15. V. Mysore, Indian Dermatol. Online J. 3, 62 (2012)
16. K. Padois, C. Cantiéni, V. Bertholle, C. Bardel, F. Pirot, F. Falson, Int. J. Pharm. 416, 300-304 (2011)
17. S. Sheikh, A. Ateeq, M.A. Shoukath, U.A. Moghis, P. Mahesh, D. Saptarshi, P. Kale, K. Maheshwari, H.V. Barkate, H.L. Pathak, M. Mushtaq, J. Clin. Exp. Dermatol. Res. 6, 253-258 (2015)
18. L.L. Levy, J.J. Emer, Int. J. Women's Health 5, 541-556 (2013)
19. H.M. Almohanna, A.A. Ahmed, J.P. Tsatalis, A. Tosti, Dermatol. Ther. 9, 51-70 (2019)
20. G.G. Aksoy, Turkderm 48, 45 (2014)
21. J.B. Mason, L. Goldman, D. Ausiello, Cecil Textb. Med. 23, 1626-1639 (2007)
22. H.B. Everts, Biochim. Biophys. Acta. 1821, 222-229 (2012)
23. K. Yamamoto, K. Sadahito, M. Yoshikawa, O. Nobuyuki, O. Mikami, M. Yamada, K. Nakamura, N. Yasuyuki, Vet. Hum. Toxicol. 45, 85-87 (2003)
24. C. Girard, O. Dereure, V. Blatiere, B. Guillot, D. Bessis. Pediatr. Dermatol. 23, 346-349 (2006)
25. W. Fujimoto, M. Inaoki, T. Fukui, Y. Inoue, T. Kuhara, J. Dermatol. 32, 256-261 (2005)
26. P.M. Coates, M.C. Paul, M. Blackman, M.R. Blackman, G.M. Cragg, M. Levine, J.D. White, J. Moss, Encyclopedia of Dietary Supplements (Online) (CRC Press, Boca Raton, 2004), pp. 421-428
27. T.H. Harvard, Three of the B vitamins:folate, vitamin B6, and vitamin B12 (Harvard TH Chan School of Public Health, Boston, MA, 2018)
28. J.M. Olmedo, J.A. Yiannias, E.B. Windgassen, M.K. Gornet, Int. J. Dermatol. 45, 909-913 (2006)
29. M.B. Demay, Arch. Biochem. Biophys. 523, 19-21 (2012)
30. R. Bouillon, G. Carmeliet, L. Verlinden, E. van Etten, A. Verstuyf, H.F. Luderer, L. Lieben, C. Mathieu, M. Demay, Endocr. Rev. 29, 726-776 (2008)
31. V. Vegesna, J. O'Kelly, M. Uskokovic, J. Said, N. Lemp, T. Saitoh, T. Ikezoe, L. Binderup, H.P. Koeffler, Endocrinology 143, 4389-4396 (2002)
32. L.A. Beoy, W.J. Woei, Y.K. Hay, Trop. Life Sci. Res. 21, 91-99 (2010)
33. M. Moeinvaziri, P. Mansoori, K. Holakooee, Z. Safaee Naraghi, A. Abbasi, Acta Dermatovenerol. Croat. 17, 279-284 (2009)
34. D.H. Rushton, Clin. Exp. Dermatol. 27, 396-404 (2002)
35. L.B. Trost, W.F. Bergfeld, E.J. Calogeras, Am. Acad. Dermatol. 54, 824-844 (2006)
36. S.A. Pierre, G.M. Vercellotti, J.C. Donovan, M.K. Hordinsky, J. Am. Acad. Dermatol. 63, 1070-1076 (2010)
37. H. Rushton, I.D. Ramsay, Clin. Endocrinol. 36, 421-427 (1992)
38. E. Alhaj, N. Alhaj, N.E. Alhaj, SKINmed 6, 199-200 (2007)
39. A.E. Slonim, N. Sadick, M. Pugliese, C.H. Meyers-Seifer, J. Pediatr. 121, 890-895 (1992)
40. M.S. Kil, C.W. Kim, S.S. Kim, Ann. Dermatol. 25, 405-409 (2013)
41. P.M. Plonka, B. Handjiski, M. Popik, D. Michalczyk, R. Paus, Exp. Dermatol. 14, 844-853 (2005)
42. J.M. Bates, V.L. Spate, J.S. Morris, D.L. Germain, V.A. Galton, Endocrinology 141, 2490-2500 (2000)
43. J.H. Upton, R.F. Hannen, A.W. Bahta, N. Farjo, B. Farjo, M.P. Philpott, J. Investig. Dermatol. 135, 1244-1252 (2015)
44. C. Pierard-Franchimont, G.E. Pierard, Dermatology 203, 115-117 (2001)
45. S.S. Khatu, Y.E. More, N.R. Gokhale, D.C. Chavhan, N.J. Bendsure, Cutan. Aesthet. Surg. 7, 107 (2014)
46. M.A. Gkini, A.E. Kouskoukis, G. Tripsianis, D. Rigopoulos, K. Kouskoukis, J. Cutan. Aesthet. Surg. 7, 213 (2014)
47. J.S. Kang, Z. Zheng, M.J. Choi, S.H. Lee, D.Y. Kim, S.B. Cho, J. Eur. Acad Dermatol. Venereol. 28, 72-79 (2014)
48. A. Trink, E. Sorbellini, P. Bezzola, L. Rodella, R. Rezzani, Y. Ramot, F. Rinaldi, Br. J. Dermatol. 169, 690-694 (2013)
49. P. Gentile, S. Garcovich, Int. J. Mol. Sci. 21, 2702 (2020)
50. T.C. Wikramanayake, R. Rodriguez, S. Choudhary, L.M. Mauro, K. Nouri, L.A. Schachner, J.J. Jimenez, Lasers Med. Sci. 27, 431-436 (2012)
51. P. Avci, A. Gupta, M. Sadasivam, D. Vecchio, Z. Pam, N. Pam, M.R. Hamblin, Semin. Cutan. Med. Surg. NIH Public Access 32, 41 (2013)
52. E. Mester, G. Ludany, M. Sellyei, B. Szende, G. Gyenes, G. Tota, J. Langenbecks Arch. Chir. 322, 1022-1027 (1968)
53. M. Leavitt, G. Charles, E. Heyman, D. Michaels, Clin. Drug Investig. 29, 283-292 (2009)
54. R.R. Marinho, R.M. Matos, J.S. Santos, M.A. Ribeiro, R.A. Ribeiro, R.C. Lima, R.L. Albuquerque, S.M. Thomazzi, Lasers Med. Sci. 29, 239-243 (2014)
55. S. Shukla, K. Sahu, Y. Verma, K.D. Rao, A. Dube, P.K. Gupta, Skin Pharmacol. Physiol. 23, 79-85 (2010)
56. J.L. Satino, M. Markou, Int. J. Cosmet. Surg. Aesthet. Dermatol. 5, 113-117 (2003)
57. H.W. Lee, J.H. Jun, J.A. Lee, H.J. Lim, H.S. Lim, M.S. Lee, BMJ Open 5, e008841 (2015)
58. Q. Zhu, F. Wu, J. Acupunct. Tuina Sci. 9, 162-164 (2011)
59. H.J. Yoon, J. Korean Med. Ophthalmol. Otolaryngol. Dermatol. 27, 162-170 (2014)
60. I.C. Hay, M. Jamieson, A.D. Ormerod, Arch. Dermatol. Res. 134, 1349-1352 (1998)
61. S. Murugusundram, J. Cutan. Aesthet. Surg. 2, 31-32 (2009)
62. M. Abe, Y. Ito, A. Suzuki, S. Onoue, H. Noguchi, S. Yamada, Anal. Sci. 25, 553-557 (2009)
63. P. Pais, A. Villar, S. Rull, Res. Rep. Urol. 8, 41-49 (2016)
64. J.O. Mccoy, C.R. Ziering, Int. J. Life Sci. Pharm. Res. 2, 31-38 (2012)
65. S.M. Chacko, P.T. Thambi, R. Kuttan, I. Nishigaki, Chin. Med. 5, 1-9 (2010)
66. A. Jigisha, R. Nishant, K. Navin, G. Pankaj, Int. Res. J. Pharm. 3, 139-148 (2012)
67. S. Farooq, A. Sehgal, Curr. Res. Nutr. Food Sci. J. 6, 35-40 (2018)
68. P.K. Jain, D.E. Das, C.H. Das, Innov. J. Med. Sci. 5, 25-33 (2017)
69. B. Lestari, E. Meiyanto, Indones. J. Cancer Chemoprev. 9, 92-101 (2018)
70. D. Montesano, F. Blasi, M.S. Simonetti, A. Santini, L. Cossignani, Foods 7, 30 (2018)
71. M.R. Al-Sereiti, K.M. Abu-Amer, P. Sena, Indian J. Exp. Biol. 37, 124-131 (1999)
72. Y. Panahi, M. Taghizadeh, E.T. Marzony, A. Sahebkar, Skin Med. 13, 15-21 (2015)
73. J. Garavaglia, M.M. Markoski, A. Oliveira, A. Marcadenti, Nutr. Metab. Insights 9, 59-64 (2016)
74. R. Kaur, H. Kaur, A.S. Dhindsa, Int. J. Pharm. Sci. Res. 4, 2470 (2013)
75. U. Sukirti, S. Vijender, Asian J. Pharm. Clin. Res. 6, 52-55 (2013)
76. K.E. Sharquie, H.K. Al-Obaidi, J. Dermatol. 29, 343-346 (2002)
77. Y. Panahi, M. Taghizadeh, E.T. Marzony, A. Sahebkar, SKINmed 13, 15-21 (2015)
78. N. Prager, K. Bickett, N. French, G. Marcovici, J. Altern. Complement. Med. 8, 143-152 (2002)
79. V. Wessagowit, C. Tangjaturonrusamee, T. Kootiratrakarn, T. Bunnag, T. Pimonrat, N. Muangdang, P. Pichai, Australas. J. Dermatol. 57, e76-e82 (2016)
80. B.E. Carbin, B. Larsson, O. Lindahl, Br. J. Urol. 66, 639-641 (1990)
81. A. Kamimura, T. Takahashi, Y. Watanabe, Phytomedicine 7, 529-536 (2000)
82. T. Takahashi, A. Kamimura, M. Kagoura, M. Toyoda, M. Morohashi, J. Cosmet. Dermatol. 4, 245-249 (2005)
83. Z. Hajheydari, M. Jamshidi, J. Akbari, R. Mohammadpour, Indian J. Dermatol. Venereol. Leprol. 73, 29-32 (2007)
84. N. Harada, K. Okajima, M. Arai, H. Kurihara, N. Nakagata, Growth Horm. IGF Res. 17, 408-415 (2007)
85. N. Harada, K. Okajima, M. Arai, H. Kurihara, N. Nakagata, Growth Horm. IGF Res. 18, 335-344 (2008)
86. T.W. Fischer, U.C. Hipler, P. Elsner, Int. J. Dermatol. 46, 27-35 (2007)
87. H. Hertel, H. Gollnick, C. Matthies, I. Baumann, C.E. Orfanos, Hautarzt 40, 490-495 (1989)
88. P. Morganti, G. Fabrizi, B. James, C. Bruno, J. Appl. Cosmetol. 16, 57-64 (1998)
89. https://www.drugbank.ca/drugs/DB14360. Accessed 4 Mar 2020
90. P. Ravva, M.R. Gastonguay, H.M. Faessel, T.C. Lee, R. Niaura, Nicotine Tob. Res. 17, 106-113 (2015)
91. https://www.medicalnewstoday.com/articles/266370. Accessed 6 May 2020
92. https://soulflower.biz/products/soulflower-rosemary-essential-oil-15-mL. Accessed 6 May 2020
93. https://www.drugs.com/mtm/grape-seed.html. Accessed 6 May 2020
94. https://www.nykaa.com/prz-grapeseed-cold-pressed-carrier-oilpure-natural-aromatherapy-massage-oil-for-skin-hair-care-15mL. Accessed 6 May 2020
95. https://www.webmd.com/vitamins/ai/ingredientmono-881/licorice. Accessed 8 May 2020
96. SoulTree-Licorice-Shampoo-Hibiscus-Conditioner/dp/B072HWDVDW. Accessed 8 May 2020
97. S. Lindquist, M. Stangel, Neuropsychiatr. Dis. Treat. 7, 341-349 (2011)
98. Clinicaltrials. https://clinicaltrials.gov/ct2/home

[1]	Hesham R. El-Seedi, Mohamed S. Refaey, Nizar Elias, Mohamed F. El-Mallah, Faisal M. K. Albaqami, Ismail Dergaa, Ming Du, Mohamed F. Salem, Haroon Elrasheid Tahir, Maria Dagliaa, Nermeen Yosri, Hongcheng Zhang, Awg H. El-Seedi, Zhiming Guo, Shaden A. M. Khalifa. Marine natural products as a source of novel anticancer drugs: an updated review (2019-2023)[J]. 应用天然产物, 2025, 15(2): 13-13.
[2]	María I. Osella, Mario O. Salazar, Carlos M. Solís, Ricardo L. E. Furlan. New semisynthetic α-glucosidase inhibitor from a doubly-chemically engineered extract[J]. 应用天然产物, 2025, 15(1): 4-4.
[3]	Ahmed H. Elbanna, Xinhui Kou, Dilip V. Prajapati, Surasree Rakshit, Rebecca A. Butcher. Discovery of a parallel family of euglenatide analogs in Euglena gracilis[J]. 应用天然产物, 2025, 15(1): 10-10.
[4]	Song-Yu Hou, Bing-Chao Yan, Han-Dong Sun, Pema-Tenzin Puno. Recent advances in the application of [2+2] cycloaddition in the chemical synthesis of cyclobutane-containing natural products[J]. 应用天然产物, 2024, 14(5): 37-37.
[5]	Felaine Anne Sumang, Alan Ward, Jeff Errington, Yousef Dashti. Hibiscus acid and hydroxycitric acid dimethyl esters from Hibiscus flowers induce production of dithiolopyrrolone antibiotics by Streptomyces Strain MBN2-2[J]. 应用天然产物, 2024, 14(5): 40-40.
[6]	Chunsong Hu. Marine natural products and human immunity: novel biomedical resources for anti-infection of SARS-CoV-2 and related cardiovascular disease[J]. 应用天然产物, 2024, 14(2): 2-2.
[7]	Shohreh Ariaeenejad, Javad Gharechahi, Mehdi Foroozandeh Shahraki, Fereshteh Fallah Atanaki, Jian-Lin Han, Xue-Zhi Ding, Falk Hildebrand, Mohammad Bahram, Kaveh Kavousi, Ghasem Hosseini Salekdeh. Precision enzyme discovery through targeted mining of metagenomic data[J]. 应用天然产物, 2024, 14(1): 7-7.
[8]	Daniel W. Armstrong, Alain Berthod. Occurrence of D-amino acids in natural products[J]. 应用天然产物, 2023, 13(6): 47-47.
[9]	Dalila Carbone, Carmela Gallo, Genoveffa Nuzzo, Giusi Barra, Mario Dell'Isola, Mario Affuso, Olimpia Follero, Federica Albiani, Clementina Sansone, Emiliano Manzo, Giuliana d'Ippolito, Angelo Fontana. Marine natural product lepadin A as a novel inducer of immunogenic cell death via CD91-dependent pathway[J]. 应用天然产物, 2023, 13(5): 34-34.
[10]	Phanankosi Moyo, Luke Invernizzi, Sephora M. Mianda, Wiehan Rudolph, Warren A. Andayi, Mingxun Wang, Neil R. Crouch, Vinesh J. Maharaj. Leveraging off higher plant phylogenetic insights for antiplasmodial drug discovery[J]. 应用天然产物, 2023, 13(5): 35-35.
[11]	Phanankosi Moyo, Luke Invernizzi, Sephora M. Mianda, Wiehan Rudolph, Andrew W. Andayi, Mingxun Wang, Neil R. Crouch, Vinesh J. Maharaj. Prioritised identification of structural classes of natural products from higher plants in the expedition of antimalarial drug discovery[J]. 应用天然产物, 2023, 13(5): 37-37.
[12]	Ji-Kai Liu. Natural products in cosmetics[J]. 应用天然产物, 2022, 12(6): 40-40.
[13]	Si-Yuan Luo, Jun-Yu Zhu, Ming-Feng Zou, Sheng Yin, Gui-Hua Tang. Mulberry Diels–Alder-type adducts: isolation, structure, bioactivity, and synthesis[J]. 应用天然产物, 2022, 12(5): 31-31.
[14]	Yulian Lv, Tian Tian, Yong-Jiang Wang, Jian-Ping Huang, Sheng-Xiong Huang. Advances in chemistry and bioactivity of the genus Erythroxylum[J]. 应用天然产物, 2022, 12(3): 15-15.
[15]	Ji-Kai Liu. Antiaging agents: safe interventions to slow aging and healthy life span extension[J]. 应用天然产物, 2022, 12(3): 18-18.

A Systemic Review on Topical Marketed Formulations, Natural Products, and Oral Supplements to Prevent Androgenic Alopecia: A Review

A Systemic Review on Topical Marketed Formulations, Natural Products, and Oral Supplements to Prevent Androgenic Alopecia: A Review

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价