Secondary Metabolites from the Endophytic Fungus Xylaria sp. Hg1009

doi:10.1007/s13659-018-0158-x

应用天然产物 ›› 2018, Vol. 8 ›› Issue (2): 121-129.DOI: 10.1007/s13659-018-0158-x

Secondary Metabolites from the Endophytic Fungus Xylaria sp. Hg1009

Rong Chen^1,2, Jian-Wei Tang^2,3, Xing-Ren Li², Miao Liu², Wen-Ping Ding^1,2, Yuan-Fei Zhou^2,3, Wei-Guang Wang², Xue Du², Han-Dong Sun², Pema-Tenzin Puno²

1 School of Chemical Science and Technology, Yunnan University, Kunming 650091, People's Republic of China;
2 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
3 University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China

收稿日期:2018-01-23 修回日期:2018-03-12 出版日期:2018-04-24 发布日期:2018-04-26
通讯作者: Pema-Tenzin Puno
基金资助:
This project was supported financially by the National Natural Science Foundation of China (81673329 and 21322204).

Secondary Metabolites from the Endophytic Fungus Xylaria sp. Hg1009

Rong Chen^1,2, Jian-Wei Tang^2,3, Xing-Ren Li², Miao Liu², Wen-Ping Ding^1,2, Yuan-Fei Zhou^2,3, Wei-Guang Wang², Xue Du², Han-Dong Sun², Pema-Tenzin Puno²

1 School of Chemical Science and Technology, Yunnan University, Kunming 650091, People's Republic of China;
2 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
3 University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China

Received:2018-01-23 Revised:2018-03-12 Online:2018-04-24 Published:2018-04-26
Contact: Pema-Tenzin Puno
Supported by:
This project was supported financially by the National Natural Science Foundation of China (81673329 and 21322204).

摘要/Abstract

摘要： A detailed chemical investigation of the secondary metabolites produced by the endophytic fungus Xylaria sp. isolated from the stems of Isodon sculponeatus afforded six new compounds, xylariahgins A-F (1-6), two new natural products (7 and 8), along with two known compounds (9 and 10) (Fig. 1). The structures of all compounds were unambiguously established by analyzing their spectroscopic data or referring to pertinent literature. Compounds 1-8 were tested for their cytotoxic activity against five human tumor cell lines.

关键词: Endophytic fungus, Xylaria sp., Secondary metabolites, Cytotoxicity

Abstract: A detailed chemical investigation of the secondary metabolites produced by the endophytic fungus Xylaria sp. isolated from the stems of Isodon sculponeatus afforded six new compounds, xylariahgins A-F (1-6), two new natural products (7 and 8), along with two known compounds (9 and 10) (Fig. 1). The structures of all compounds were unambiguously established by analyzing their spectroscopic data or referring to pertinent literature. Compounds 1-8 were tested for their cytotoxic activity against five human tumor cell lines.

Key words: Endophytic fungus, Xylaria sp., Secondary metabolites, Cytotoxicity

Rong Chen, Jian-Wei Tang, Xing-Ren Li, Miao Liu, Wen-Ping Ding, Yuan-Fei Zhou, Wei-Guang Wang, Xue Du, Han-Dong Sun, Pema-Tenzin Puno. Secondary Metabolites from the Endophytic Fungus Xylaria sp. Hg1009[J]. 应用天然产物, 2018, 8(2): 121-129.

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Secondary Metabolites from the Endophytic Fungus Xylaria sp. Hg1009

Secondary Metabolites from the Endophytic Fungus Xylaria sp. Hg1009

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