Xylariaides A and B, novel cytochalasans with a unique 5/6/5/3 ring system from a soil fungus Xylaria sp. Y01

doi:10.1007/s13659-025-00507-w

应用天然产物 ›› 2025, Vol. 15 ›› Issue (3): 23-23.DOI: 10.1007/s13659-025-00507-w

• ORIGINAL ARTICLES • 上一篇下一篇

Xylariaides A and B, novel cytochalasans with a unique 5/6/5/3 ring system from a soil fungus Xylaria sp. Y01

Yi-Yun Yuan¹, Yan Li¹, Wen-Yu Lu¹, Ai-Lin Liang¹, Jing Li^1,2,3, Wen-Xuan Wang^1,3

1. Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, 410008, Hunan, People's Republic of China;
2. Department of Pharmacy, National Clinical Research Center for Geriatric Disorder, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, People's Republic of China;
3. Hunan Research Center for Drug Safety Evaluation, Hunan Key Laboratory of Pharmacodynamics and Safety Evaluation of New Drugs, Hunan Prima Drug Research Center Co., Ltd, Changsha, 410331, Hunan, People's Republic of China

收稿日期:2024-12-23 接受日期:2025-03-20 出版日期:2025-06-24 发布日期:2025-06-18
通讯作者: Jing Li Email:E-mail:lijingliyun@csu.edu.cn;Wen-Xuan Wang Email:E-mail:wangwenxuan@csu.edu.cn
基金资助:
This work was supported by National Natural Science Foundation of China (82173713), Key Research and Development Program of Hunan Province (2022SK2031), and Natural Science Foundation of Hunan Province (2024JJ8127). Project of Hunan Administration of Traditional Chinese Medicine (B2023059), Changsha Municipal Natural Science Foundation (kq2403041).

Xylariaides A and B, novel cytochalasans with a unique 5/6/5/3 ring system from a soil fungus Xylaria sp. Y01

Yi-Yun Yuan¹, Yan Li¹, Wen-Yu Lu¹, Ai-Lin Liang¹, Jing Li^1,2,3, Wen-Xuan Wang^1,3

1. Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, 410008, Hunan, People's Republic of China;
2. Department of Pharmacy, National Clinical Research Center for Geriatric Disorder, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, People's Republic of China;
3. Hunan Research Center for Drug Safety Evaluation, Hunan Key Laboratory of Pharmacodynamics and Safety Evaluation of New Drugs, Hunan Prima Drug Research Center Co., Ltd, Changsha, 410331, Hunan, People's Republic of China

Received:2024-12-23 Accepted:2025-03-20 Online:2025-06-24 Published:2025-06-18
Supported by:
This work was supported by National Natural Science Foundation of China (82173713), Key Research and Development Program of Hunan Province (2022SK2031), and Natural Science Foundation of Hunan Province (2024JJ8127). Project of Hunan Administration of Traditional Chinese Medicine (B2023059), Changsha Municipal Natural Science Foundation (kq2403041).

摘要/Abstract

摘要： Two new cytochalasans, xylariaides A (1) and B (2), were isolated and identified from a soil fungus Xylaria sp. Y01. Their structures were unambiguously determined by extensive spectroscopic methods including high resolution electrospray ionization mass spectrometry, ultraviolet radiation, infrared spectroscopy, and 1D/2D NMR, as well as in-depth quantum chemical calculations of gauge-including atomic orbital (GIAO) ¹³C NMR chemical shifts, electronic circular dichroism (ECD), and spin-spin coupling constants. The unprecedented core structure with a 5/6/5/3 fused tetracyclic ring system further enriches the scaffold types of cytochalasans.

关键词: Cytochalasins, Xylaria sp., Coupling constant calculation, ECD calculation, GIAO ¹³C NMR calculation

Abstract: Two new cytochalasans, xylariaides A (1) and B (2), were isolated and identified from a soil fungus Xylaria sp. Y01. Their structures were unambiguously determined by extensive spectroscopic methods including high resolution electrospray ionization mass spectrometry, ultraviolet radiation, infrared spectroscopy, and 1D/2D NMR, as well as in-depth quantum chemical calculations of gauge-including atomic orbital (GIAO) ¹³C NMR chemical shifts, electronic circular dichroism (ECD), and spin-spin coupling constants. The unprecedented core structure with a 5/6/5/3 fused tetracyclic ring system further enriches the scaffold types of cytochalasans.

Key words: Cytochalasins, Xylaria sp., Coupling constant calculation, ECD calculation, GIAO ¹³C NMR calculation

Yi-Yun Yuan, Yan Li, Wen-Yu Lu, Ai-Lin Liang, Jing Li, Wen-Xuan Wang. Xylariaides A and B, novel cytochalasans with a unique 5/6/5/3 ring system from a soil fungus Xylaria sp. Y01[J]. 应用天然产物, 2025, 15(3): 23-23.

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Xylariaides A and B, novel cytochalasans with a unique 5/6/5/3 ring system from a soil fungus Xylaria sp. Y01

Xylariaides A and B, novel cytochalasans with a unique 5/6/5/3 ring system from a soil fungus Xylaria sp. Y01

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