Scutellarin ameliorates diabetic nephropathy via TGF-β1 signaling pathway

doi:10.1007/s13659-024-00446-y

应用天然产物 ›› 2024, Vol. 14 ›› Issue (3): 25-25.DOI: 10.1007/s13659-024-00446-y

• ORIGINAL ARTICLES • 上一篇下一篇

Scutellarin ameliorates diabetic nephropathy via TGF-β1 signaling pathway

Bangrui Huang^1,2, Rui Han¹, Hong Tan¹, Wenzhuo Zhu¹, Yang Li¹, Fakun Jiang², Chun Xie², Zundan Ren¹, Rou Shi¹

1 Department of Endocrinology, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, People's Republic of China;
2 Key Laboratory of Medicinal Chemistry for Natural Resource(Ministry of Education) Yunnan Provincial Center for Research and Development of Natural Products, School of Pharmacy, Yunnan University, Kunming 650500, People's Republic of China

收稿日期:2024-03-08 发布日期:2024-06-14
通讯作者: Rou Shi,E-mail:shirourou325@sina.com
基金资助:
This work was supported by Yunnan Province Clinical Research Center for Metabolic diseases(202102AA100056); Scientific and Technological Innovation Team of Kunming Medical University (CXTD202101); Union Foundation of Yunnan Provincial Science and Technology Department and Kunming Medical University (202001AY070001-034); Yunnan health training project of high level talents (D-2019011).

Scutellarin ameliorates diabetic nephropathy via TGF-β1 signaling pathway

Bangrui Huang^1,2, Rui Han¹, Hong Tan¹, Wenzhuo Zhu¹, Yang Li¹, Fakun Jiang², Chun Xie², Zundan Ren¹, Rou Shi¹

1 Department of Endocrinology, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, People's Republic of China;
2 Key Laboratory of Medicinal Chemistry for Natural Resource(Ministry of Education) Yunnan Provincial Center for Research and Development of Natural Products, School of Pharmacy, Yunnan University, Kunming 650500, People's Republic of China

Received:2024-03-08 Published:2024-06-14
Contact: Rou Shi,E-mail:shirourou325@sina.com
Supported by:
This work was supported by Yunnan Province Clinical Research Center for Metabolic diseases(202102AA100056); Scientific and Technological Innovation Team of Kunming Medical University (CXTD202101); Union Foundation of Yunnan Provincial Science and Technology Department and Kunming Medical University (202001AY070001-034); Yunnan health training project of high level talents (D-2019011).

摘要/Abstract

摘要： Breviscapine, a natural flavonoid mixture derived from the traditional Chinese herb Erigeron breviscapus (Vant.) Hand-Mazz, has demonstrated a promising potential in improving diabetic nephropathy (DN). However, the specific active constituent(s) responsible for its therapeutic effects and the underlying pharmacological mechanisms remain unclear. In this study, we aimed to investigate the impact of scutellarin, a constituent of breviscapine, on streptozotocin- induced diabetic nephropathy and elucidate its pharmacological mechanism(s). Our findings demonstrate that scutellarin effectively ameliorates various features of DN in vivo, including proteinuria, glomerular expansion, mesangial matrix accumulation, renal fibrosis, and podocyte injury. Mechanistically, scutellarin appears to exert its beneficial effects through modulation of the transforming growth factor-β1 (TGF-β1) signaling pathway, as well as its interaction with the extracellular signal-regulated kinase (Erk) and Wnt/β-catenin pathways.

关键词: Scutellarin, Diabetic nephropathy, Proteinuria, Fibrosis, Podocyte injury

Abstract: Breviscapine, a natural flavonoid mixture derived from the traditional Chinese herb Erigeron breviscapus (Vant.) Hand-Mazz, has demonstrated a promising potential in improving diabetic nephropathy (DN). However, the specific active constituent(s) responsible for its therapeutic effects and the underlying pharmacological mechanisms remain unclear. In this study, we aimed to investigate the impact of scutellarin, a constituent of breviscapine, on streptozotocin- induced diabetic nephropathy and elucidate its pharmacological mechanism(s). Our findings demonstrate that scutellarin effectively ameliorates various features of DN in vivo, including proteinuria, glomerular expansion, mesangial matrix accumulation, renal fibrosis, and podocyte injury. Mechanistically, scutellarin appears to exert its beneficial effects through modulation of the transforming growth factor-β1 (TGF-β1) signaling pathway, as well as its interaction with the extracellular signal-regulated kinase (Erk) and Wnt/β-catenin pathways.

Key words: Scutellarin, Diabetic nephropathy, Proteinuria, Fibrosis, Podocyte injury

Bangrui Huang, Rui Han, Hong Tan, Wenzhuo Zhu, Yang Li, Fakun Jiang, Chun Xie, Zundan Ren, Rou Shi. Scutellarin ameliorates diabetic nephropathy via TGF-β1 signaling pathway[J]. 应用天然产物, 2024, 14(3): 25-25.

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Scutellarin ameliorates diabetic nephropathy via TGF-β1 signaling pathway

Scutellarin ameliorates diabetic nephropathy via TGF-β1 signaling pathway

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