Uncarialines A-E, new alkaloids from Uncaria rhynchophylla and their anticoagulant activity

doi:10.1007/s13659-023-00377-0

应用天然产物 ›› 2023, Vol. 13 ›› Issue (2): 13-13.DOI: 10.1007/s13659-023-00377-0

• Original Article • 上一篇

Uncarialines A-E, new alkaloids from Uncaria rhynchophylla and their anticoagulant activity

Ke-Pu Huang^1,2, Li-Li Xu², Sheng Li², Yin-Ling Wei², Lian Yang², Xiao-Jiang Hao², Hong-Ping He¹, Yu Zhang²

1. School of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming, 650500, People's Republic of China;
2. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China

收稿日期:2023-03-09 出版日期:2023-04-24 发布日期:2023-05-18
通讯作者: Hong-Ping He,E-mail:hehongping@yahoo.com;Yu Zhang,E-mail:zhangyu@mail.kib.ac.cn
基金资助:
This work was financially supported by Yunnan Applied Basic Research Projects (No. 202301AS070057), National Key R&D Program of China (No. 2022YFF1100301), and Yunnan Revitalization Talents Support Plan-Young Talent Project (to Y. Zhang).

Uncarialines A-E, new alkaloids from Uncaria rhynchophylla and their anticoagulant activity

Ke-Pu Huang^1,2, Li-Li Xu², Sheng Li², Yin-Ling Wei², Lian Yang², Xiao-Jiang Hao², Hong-Ping He¹, Yu Zhang²

1. School of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming, 650500, People's Republic of China;
2. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China

Received:2023-03-09 Online:2023-04-24 Published:2023-05-18
Contact: Hong-Ping He,E-mail:hehongping@yahoo.com;Yu Zhang,E-mail:zhangyu@mail.kib.ac.cn
Supported by:
This work was financially supported by Yunnan Applied Basic Research Projects (No. 202301AS070057), National Key R&D Program of China (No. 2022YFF1100301), and Yunnan Revitalization Talents Support Plan-Young Talent Project (to Y. Zhang).

摘要/Abstract

摘要： Uncarialines A-E (1-5), five undescribed monoterpene indole alkaloids, together with five known analogues were obtained from the stems of Uncaria rhynchophylla. Alkaloids 1-3 were unique 3,4-seco-tricyclic alkaloids with a 6/5/10 ring system, while 4 and 5 possessed a rare rearranged scaffold originated from corynantheine-type alkaloids with C-2/C-7 oxidation. Their structures were characterized by a comprehensive analysis of MS, NMR, and ECD. Their effects on blood clotting times of human plasma were evaluated and alkaloid 5 had a slight prolongation effect on both thrombin time and activated partial thromboplastin time (p<0.001).

关键词: Uncaria rhynchophylla, Monoterpene indole alkaloids, Uncarialines A-E, Anticoagulant activity

Abstract: Uncarialines A-E (1-5), five undescribed monoterpene indole alkaloids, together with five known analogues were obtained from the stems of Uncaria rhynchophylla. Alkaloids 1-3 were unique 3,4-seco-tricyclic alkaloids with a 6/5/10 ring system, while 4 and 5 possessed a rare rearranged scaffold originated from corynantheine-type alkaloids with C-2/C-7 oxidation. Their structures were characterized by a comprehensive analysis of MS, NMR, and ECD. Their effects on blood clotting times of human plasma were evaluated and alkaloid 5 had a slight prolongation effect on both thrombin time and activated partial thromboplastin time (p<0.001).

Key words: Uncaria rhynchophylla, Monoterpene indole alkaloids, Uncarialines A-E, Anticoagulant activity

Ke-Pu Huang, Li-Li Xu, Sheng Li, Yin-Ling Wei, Lian Yang, Xiao-Jiang Hao, Hong-Ping He, Yu Zhang. Uncarialines A-E, new alkaloids from Uncaria rhynchophylla and their anticoagulant activity[J]. 应用天然产物, 2023, 13(2): 13-13.

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Uncarialines A-E, new alkaloids from Uncaria rhynchophylla and their anticoagulant activity

Uncarialines A-E, new alkaloids from Uncaria rhynchophylla and their anticoagulant activity

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