Two New C21 Steroidal Glycosides from the Roots of Cynanchum paniculatum

doi:10.1007/s13659-019-0205-2

应用天然产物 ›› 2019, Vol. 9 ›› Issue (3): 209-214.DOI: 10.1007/s13659-019-0205-2

• ORIGINAL ARTICLES • 上一篇下一篇

Two New C21 Steroidal Glycosides from the Roots of Cynanchum paniculatum

Hai-Li Yu^1,2, Qin Long^1,2, Wen-Fang Yi^1,2, Bao-Jia Yang^1,2, Yu Song^1,2, Xiao Ding¹, Shun-Lin Li¹, Xiao-Jiang Hao¹

1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
2 University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China

收稿日期:2019-02-27 修回日期:2019-04-09 出版日期:2019-06-24 发布日期:2019-06-05
通讯作者: Xiao Ding, Shun-Lin Li
基金资助:
This project was supported financially by grants from the National Natural Science Foundation of China (Nos. 31770389, 81703393).

Two New C21 Steroidal Glycosides from the Roots of Cynanchum paniculatum

Hai-Li Yu^1,2, Qin Long^1,2, Wen-Fang Yi^1,2, Bao-Jia Yang^1,2, Yu Song^1,2, Xiao Ding¹, Shun-Lin Li¹, Xiao-Jiang Hao¹

1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
2 University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China

Received:2019-02-27 Revised:2019-04-09 Online:2019-06-24 Published:2019-06-05
Contact: Xiao Ding, Shun-Lin Li
Supported by:
This project was supported financially by grants from the National Natural Science Foundation of China (Nos. 31770389, 81703393).

摘要/Abstract

摘要： Two new C21 steroidal glycosides, paniculatumosides H and I, together with four known ones were isolated from the roots of Cynanchum paniculatum (Bge.) Kitag. Their structures were identified by spectroscopic methods including extensive 1D and 2D NMR techniques. All compounds were subjected to detect the anti-tobacco mosaic virus (TMV) activities and their cytotoxities against three human tumor cell lines (SMMC-7721, MDA-MB-231 and A549). The results showed that compounds 1 and 5 exhibited potent protective activities against TMV, while 2, 4 and 6 had moderate effects on the SMMC-7721 cancer cells viability.

关键词: Cynanchum paniculatum, Steroidal glycosides, Bioactivities, NMR data

Abstract: Two new C21 steroidal glycosides, paniculatumosides H and I, together with four known ones were isolated from the roots of Cynanchum paniculatum (Bge.) Kitag. Their structures were identified by spectroscopic methods including extensive 1D and 2D NMR techniques. All compounds were subjected to detect the anti-tobacco mosaic virus (TMV) activities and their cytotoxities against three human tumor cell lines (SMMC-7721, MDA-MB-231 and A549). The results showed that compounds 1 and 5 exhibited potent protective activities against TMV, while 2, 4 and 6 had moderate effects on the SMMC-7721 cancer cells viability.

Key words: Cynanchum paniculatum, Steroidal glycosides, Bioactivities, NMR data

Hai-Li Yu, Qin Long, Wen-Fang Yi, Bao-Jia Yang, Yu Song, Xiao Ding, Shun-Lin Li, Xiao-Jiang Hao. Two New C21 Steroidal Glycosides from the Roots of Cynanchum paniculatum[J]. 应用天然产物, 2019, 9(3): 209-214.

Hai-Li Yu, Qin Long, Wen-Fang Yi, Bao-Jia Yang, Yu Song, Xiao Ding, Shun-Lin Li, Xiao-Jiang Hao. Two New C21 Steroidal Glycosides from the Roots of Cynanchum paniculatum[J]. Natural Products and Bioprospecting, 2019, 9(3): 209-214.

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Two New C21 Steroidal Glycosides from the Roots of Cynanchum paniculatum

Two New C21 Steroidal Glycosides from the Roots of Cynanchum paniculatum

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