Antitumor Research on Artemisinin and Its Bioactive Derivatives

doi:10.1007/s13659-018-0162-1

应用天然产物 ›› 2018, Vol. 8 ›› Issue (4): 303-319.DOI: 10.1007/s13659-018-0162-1

Antitumor Research on Artemisinin and Its Bioactive Derivatives

Yunqin Zhang^1,2, Guowei Xu^1,2, Shuqun Zhang¹, Dong Wang¹, P. Saravana Prabha¹, Zhili Zuo^1,3

1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
2 University of the Chinese Academy of Sciences, Beijing 100049, China;
3 Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, Yunnan, China

收稿日期:2018-01-09 修回日期:2018-03-27 出版日期:2018-08-24 发布日期:2018-08-28
通讯作者: Zhili Zuo,zuozhili@mail.kib.ac.cn
基金资助:
This work was financially supported by CAS "Light of West China" Program ([2014]91 to Z.Z.), the Basic Research Plan of Yunnan Provincial Science and Technology Department (grant number 2014FA042), CAS Strategic biological resources service network (ZSTH-021),and the Strategic Priority Research Program of the Chinese Academy of Sciences,Grant No. XDA12030206.

Antitumor Research on Artemisinin and Its Bioactive Derivatives

Yunqin Zhang^1,2, Guowei Xu^1,2, Shuqun Zhang¹, Dong Wang¹, P. Saravana Prabha¹, Zhili Zuo^1,3

1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
2 University of the Chinese Academy of Sciences, Beijing 100049, China;
3 Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, Yunnan, China

Received:2018-01-09 Revised:2018-03-27 Online:2018-08-24 Published:2018-08-28
Contact: Zhili Zuo,zuozhili@mail.kib.ac.cn
Supported by:
This work was financially supported by CAS "Light of West China" Program ([2014]91 to Z.Z.), the Basic Research Plan of Yunnan Provincial Science and Technology Department (grant number 2014FA042), CAS Strategic biological resources service network (ZSTH-021),and the Strategic Priority Research Program of the Chinese Academy of Sciences,Grant No. XDA12030206.

摘要/Abstract

摘要： Cancer is the leading cause of human death which seriously threatens human life. The antimalarial drug artemisinin and its derivatives have been discovered with considerable anticancer properties. Simultaneously, a variety of target-selective artemisinin-related compounds with high efficiency have been discovered. Many researches indicated that artemisininrelated compounds have cytotoxic effects against a variety of cancer cells through pleiotropic effects, including inhibiting the proliferation of tumor cells, promoting apoptosis, inducing cell cycle arrest, disrupting cancer invasion and metastasis, preventing angiogenesis, mediating the tumor-related signaling pathways, and regulating tumor microenvironment. More importantly, artemisinins demonstrated minor side effects to normal cells and manifested the ability to overcome multidrug-resistance which is widely observed in cancer patients. Therefore, we concentrated on the new advances and development of artemisinin and its derivatives as potential antitumor agents in recent 5 years. It is our hope that this review could be helpful for further exploration of novel artemisinin-related antitumor agents.

关键词: Artemisinin, Artemisinin derivatives, Antitumor, Activity, Mechanism

Abstract: Cancer is the leading cause of human death which seriously threatens human life. The antimalarial drug artemisinin and its derivatives have been discovered with considerable anticancer properties. Simultaneously, a variety of target-selective artemisinin-related compounds with high efficiency have been discovered. Many researches indicated that artemisininrelated compounds have cytotoxic effects against a variety of cancer cells through pleiotropic effects, including inhibiting the proliferation of tumor cells, promoting apoptosis, inducing cell cycle arrest, disrupting cancer invasion and metastasis, preventing angiogenesis, mediating the tumor-related signaling pathways, and regulating tumor microenvironment. More importantly, artemisinins demonstrated minor side effects to normal cells and manifested the ability to overcome multidrug-resistance which is widely observed in cancer patients. Therefore, we concentrated on the new advances and development of artemisinin and its derivatives as potential antitumor agents in recent 5 years. It is our hope that this review could be helpful for further exploration of novel artemisinin-related antitumor agents.

Key words: Artemisinin, Artemisinin derivatives, Antitumor, Activity, Mechanism

Yunqin Zhang, Guowei Xu, Shuqun Zhang, Dong Wang, P. Saravana Prabha, Zhili Zuo. Antitumor Research on Artemisinin and Its Bioactive Derivatives[J]. 应用天然产物, 2018, 8(4): 303-319.

Yunqin Zhang, Guowei Xu, Shuqun Zhang, Dong Wang, P. Saravana Prabha, Zhili Zuo. Antitumor Research on Artemisinin and Its Bioactive Derivatives[J]. Natural Products and Bioprospecting, 2018, 8(4): 303-319.

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Antitumor Research on Artemisinin and Its Bioactive Derivatives

Antitumor Research on Artemisinin and Its Bioactive Derivatives

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