Three New Indole Alkaloids from Tabernaemontana divaricata

doi:10.1007/s13659-018-0166-x

应用天然产物 ›› 2018, Vol. 8 ›› Issue (3): 183-188.DOI: 10.1007/s13659-018-0166-x

• ORIGINAL ARTICLE • 上一篇下一篇

Three New Indole Alkaloids from Tabernaemontana divaricata

Yan Deng^1,2,3, Mei-Fen Bao^1,3, Bao-Bao Shi^1,2,3, Jing Wu^1,3, Xiang-Hai Cai^1,3

1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
2 University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China;
3 Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, People's Republic of China

收稿日期:2018-03-08 修回日期:2018-05-03 出版日期:2018-06-24 发布日期:2018-06-06
通讯作者: Xiang-Hai Cai
基金资助:
This project was financially supported by the Applied Basic Research Programs of Yunnan Province (No. 2016FA030) and the National Natural Science Foundation of China (31370377).

Three New Indole Alkaloids from Tabernaemontana divaricata

Yan Deng^1,2,3, Mei-Fen Bao^1,3, Bao-Bao Shi^1,2,3, Jing Wu^1,3, Xiang-Hai Cai^1,3

1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
2 University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China;
3 Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, People's Republic of China

Received:2018-03-08 Revised:2018-05-03 Online:2018-06-24 Published:2018-06-06
Contact: Xiang-Hai Cai
Supported by:
This project was financially supported by the Applied Basic Research Programs of Yunnan Province (No. 2016FA030) and the National Natural Science Foundation of China (31370377).

摘要/Abstract

摘要： Three new monoterpene indole alkaloids, 3α-hydroxymethyl-ibogamine (1), 3α-acetatemethoxyl-ibogamine (2), 16α-hydroxyl-ibogamine (3) together with six known alkaloids were isolated from the branches and leaves of Tabernaemontana divaricata (Apocynaceae). The structures of these alkaloids were determined by spectroscopic analyses. All isolated compounds showed no significant cytotoxicity against SGC-7901 gastric cancer, HeLa, and A-549 lung cancer cell lines(IC₅₀>20 μM).

关键词: Tabernaemontana divaricata, Monoterpene indole alkaloids, 3α-hydroxymethyl-ibogamine, 3α-acetatemethoxyl-ibogamine, 16α-hydroxyl-ibogamine, Apocynaceae

Abstract: Three new monoterpene indole alkaloids, 3α-hydroxymethyl-ibogamine (1), 3α-acetatemethoxyl-ibogamine (2), 16α-hydroxyl-ibogamine (3) together with six known alkaloids were isolated from the branches and leaves of Tabernaemontana divaricata (Apocynaceae). The structures of these alkaloids were determined by spectroscopic analyses. All isolated compounds showed no significant cytotoxicity against SGC-7901 gastric cancer, HeLa, and A-549 lung cancer cell lines(IC₅₀>20 μM).

Key words: Tabernaemontana divaricata, Monoterpene indole alkaloids, 3α-hydroxymethyl-ibogamine, 3α-acetatemethoxyl-ibogamine, 16α-hydroxyl-ibogamine, Apocynaceae

Yan Deng, Mei-Fen Bao, Bao-Bao Shi, Jing Wu, Xiang-Hai Cai. Three New Indole Alkaloids from Tabernaemontana divaricata[J]. 应用天然产物, 2018, 8(3): 183-188.

Yan Deng, Mei-Fen Bao, Bao-Bao Shi, Jing Wu, Xiang-Hai Cai. Three New Indole Alkaloids from Tabernaemontana divaricata[J]. Natural Products and Bioprospecting, 2018, 8(3): 183-188.

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Three New Indole Alkaloids from Tabernaemontana divaricata

Three New Indole Alkaloids from Tabernaemontana divaricata

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