整合生物学期刊网

应用天然产物 ›› 2018, Vol. 8 ›› Issue (2): 107-111.DOI: 10.1007/s13659-018-0156-z

• ORIGINAL ARTICLES • 上一篇    下一篇

Two New Indolyl Diketopiperazines, Trypostatins C and D from Aspergillus penicilliodes Speg.

Han Zhang1,2, Hong-Tao Zhu1, Dong Wang1, Chong-Ren Yang1, Ying-Jun Zhang1,3   

  1. 1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
    2 University of Chinese Academy of Sciences, Beijing 100049, China;
    3 Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China
  • 收稿日期:2018-01-28 修回日期:2018-03-01 出版日期:2018-04-24 发布日期:2018-04-26
  • 通讯作者: Ying-Jun Zhang
  • 基金资助:
    This work was supported by the National Natural Science Foundation of China (No. 21672223). The authors are grateful to the staffs of the analytical and bioactivity screening groups at State Key Laboratory of Phytochemistry and Plant Resources in West China, KIB, CAS, for measuring the spectroscopic data and bioactivities.

Two New Indolyl Diketopiperazines, Trypostatins C and D from Aspergillus penicilliodes Speg.

Han Zhang1,2, Hong-Tao Zhu1, Dong Wang1, Chong-Ren Yang1, Ying-Jun Zhang1,3   

  1. 1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
    2 University of Chinese Academy of Sciences, Beijing 100049, China;
    3 Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China
  • Received:2018-01-28 Revised:2018-03-01 Online:2018-04-24 Published:2018-04-26
  • Contact: Ying-Jun Zhang
  • Supported by:
    This work was supported by the National Natural Science Foundation of China (No. 21672223). The authors are grateful to the staffs of the analytical and bioactivity screening groups at State Key Laboratory of Phytochemistry and Plant Resources in West China, KIB, CAS, for measuring the spectroscopic data and bioactivities.

摘要: Twelve indolyl diketopiperazines 1-12 were isolated from the mycelia culture of Aspergillus penicilliodes Speg., a dominant microorganism from the post fermentation process of ripe Pu-er tea. Their structures were elucidated by extensive spectroscopic methods. Among them, trypostatins C (1) and D (2) featuring with a rare methyl vinyl ketone side chain at C-2 are new compounds, while 3 and 4 were obtained for the first time from nature source. The isolates 3-12 did not show obvious cytotoxicities against five human cancer cell lines at a concentration of 40 μM.

关键词: Aspergillus penicilliodes Speg., Indolyl diketopiperazines, Trypostatins

Abstract: Twelve indolyl diketopiperazines 1-12 were isolated from the mycelia culture of Aspergillus penicilliodes Speg., a dominant microorganism from the post fermentation process of ripe Pu-er tea. Their structures were elucidated by extensive spectroscopic methods. Among them, trypostatins C (1) and D (2) featuring with a rare methyl vinyl ketone side chain at C-2 are new compounds, while 3 and 4 were obtained for the first time from nature source. The isolates 3-12 did not show obvious cytotoxicities against five human cancer cell lines at a concentration of 40 μM.

Key words: Aspergillus penicilliodes Speg., Indolyl diketopiperazines, Trypostatins