Cannabinomimetric Lipids: From Natural Extract to Artificial Synthesis

doi:10.1007/s13659-017-0151-9

应用天然产物 ›› 2018, Vol. 8 ›› Issue (1): 1-21.DOI: 10.1007/s13659-017-0151-9

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Cannabinomimetric Lipids: From Natural Extract to Artificial Synthesis

Ya-Ru Gao, Yong-Qiang Wang

Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, Department of Chemistry & Materials Science, Northwest University, Xi'an 710069, People's Republic of China

收稿日期:2017-10-30 修回日期:2017-12-28 出版日期:2018-02-24 发布日期:2018-02-27
基金资助:
We are grateful for financial support from National Natural Science Foundation of China (NSFC-21572178 and NSFC-21702162).

Cannabinomimetric Lipids: From Natural Extract to Artificial Synthesis

Ya-Ru Gao, Yong-Qiang Wang

Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, Department of Chemistry & Materials Science, Northwest University, Xi'an 710069, People's Republic of China

Received:2017-10-30 Revised:2017-12-28 Online:2018-02-24 Published:2018-02-27
Contact: Yong-Qiang Wang

摘要/Abstract

摘要： Endocannabinoid system is related with various physiological and cognitive processes including fertility, pregnancy, during pre-and postnatal development, pain-sensation, mood, appetite, and memory. In the latest decades, an important milestone concerning the endocannabinoid system was the discovery of the existence of the cannabinoid receptors CB₁ and CB₂. Anandamide was the first reported endogenous metabolite, which adjusted the release of some neurotransmitters through binding to the CB₁ or CB₂ receptors. Then a series of cannabinomimetric lipids were extracted from marine organisms, which possessed similar structure with anandamide. This review will provide a short account about cannabinomimetric lipids for their extraction and synthesis.

关键词: Endocannabinoid, Cannabinoid receptors, Cannabinomimetric lipids

Abstract: Endocannabinoid system is related with various physiological and cognitive processes including fertility, pregnancy, during pre-and postnatal development, pain-sensation, mood, appetite, and memory. In the latest decades, an important milestone concerning the endocannabinoid system was the discovery of the existence of the cannabinoid receptors CB₁ and CB₂. Anandamide was the first reported endogenous metabolite, which adjusted the release of some neurotransmitters through binding to the CB₁ or CB₂ receptors. Then a series of cannabinomimetric lipids were extracted from marine organisms, which possessed similar structure with anandamide. This review will provide a short account about cannabinomimetric lipids for their extraction and synthesis.

Key words: Endocannabinoid, Cannabinoid receptors, Cannabinomimetric lipids

Ya-Ru Gao, Yong-Qiang Wang. Cannabinomimetric Lipids: From Natural Extract to Artificial Synthesis[J]. 应用天然产物, 2018, 8(1): 1-21.

Ya-Ru Gao, Yong-Qiang Wang. Cannabinomimetric Lipids: From Natural Extract to Artificial Synthesis[J]. Natural Products and Bioprospecting, 2018, 8(1): 1-21.

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Cannabinomimetric Lipids: From Natural Extract to Artificial Synthesis

Cannabinomimetric Lipids: From Natural Extract to Artificial Synthesis

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