整合生物学期刊网

应用天然产物 ›› 2017, Vol. 7 ›› Issue (4): 307-313.DOI: 10.1007/s13659-017-0133-y

• Original article • 上一篇    下一篇

Clausenlanins A and B, Two Leucine-Rich Cyclic Nonapeptides from Clausena lansium

Shai-Ping Hu1,2, Wei-Wu Song2,3, Si-Meng Zhao2, Ning-Hua Tan1,2   

  1. 1. School of Traditional Chinese Pharmacy and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 211198, Jiangsu, People's Republic of China;
    2. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, People's Republic of China;
    3. School of Chemistry & Chemical Engineeing, Zhoukou Normal University, Zhoukou 466001, Henan, People's Republic of China
  • 收稿日期:2017-05-08 修回日期:2017-05-15 出版日期:2017-08-24 发布日期:2018-02-07
  • 通讯作者: Ning-Hua Tan,e-mail:nhtan@cpu.edu.cn
  • 基金资助:
    This work was supported by the Program for Jiangsu Province Innovative Research Team, the National Basic Research Program of China (2013CB127505), the National Natural Science Foundation of China (31470428), the Project of State Key Laboratory of Natural Medicines (SKLNMZZCX201614), and the Foundation of High-level Talent Introduction of China Pharmaceutical University.

Clausenlanins A and B, Two Leucine-Rich Cyclic Nonapeptides from Clausena lansium

Shai-Ping Hu1,2, Wei-Wu Song2,3, Si-Meng Zhao2, Ning-Hua Tan1,2   

  1. 1. School of Traditional Chinese Pharmacy and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 211198, Jiangsu, People's Republic of China;
    2. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, People's Republic of China;
    3. School of Chemistry & Chemical Engineeing, Zhoukou Normal University, Zhoukou 466001, Henan, People's Republic of China
  • Received:2017-05-08 Revised:2017-05-15 Online:2017-08-24 Published:2018-02-07
  • Supported by:
    This work was supported by the Program for Jiangsu Province Innovative Research Team, the National Basic Research Program of China (2013CB127505), the National Natural Science Foundation of China (31470428), the Project of State Key Laboratory of Natural Medicines (SKLNMZZCX201614), and the Foundation of High-level Talent Introduction of China Pharmaceutical University.

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摘要： Two new cyclic nonapeptides, named clausenlanins A (1) and B (2), were isolated from the roots and rhizomes of Clausena lansium. Their structures were elucidated as cyclo-(Gly1-L-Leu2-L-Ile3-L-Leu4-L-Leu5-L-Leu6-L-Leu7-L-Leu8- L-Leu9) (1) and cyclo-(Gly1-L-Leu2-L-Val3-L-Leu4-L-Leu5-L-Leu6-L-Leu7-L-Leu8-L-Leu9) (2) respectively on the basis of extensive spectroscopic analysis, particularly 2D NMR spectra taken at the temperature of 338 or 303 K and MS.

关键词: Clausena lansium, Cyclopeptides, Clausenlanin A, Clausenlanin B

Abstract: Two new cyclic nonapeptides, named clausenlanins A (1) and B (2), were isolated from the roots and rhizomes of Clausena lansium. Their structures were elucidated as cyclo-(Gly1-L-Leu2-L-Ile3-L-Leu4-L-Leu5-L-Leu6-L-Leu7-L-Leu8- L-Leu9) (1) and cyclo-(Gly1-L-Leu2-L-Val3-L-Leu4-L-Leu5-L-Leu6-L-Leu7-L-Leu8-L-Leu9) (2) respectively on the basis of extensive spectroscopic analysis, particularly 2D NMR spectra taken at the temperature of 338 or 303 K and MS.

Key words: Clausena lansium, Cyclopeptides, Clausenlanin A, Clausenlanin B

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