Clerodane Diterpenoids with Anti-hyperglycemic Activity from Tinospora crispa

doi:10.1007/s13659-016-0109-3

应用天然产物 ›› 2016, Vol. 6 ›› Issue (5): 247-255.DOI: 10.1007/s13659-016-0109-3

Clerodane Diterpenoids with Anti-hyperglycemic Activity from Tinospora crispa

Yuan Gao^1,2,3, Yan-Fen Niu^1,4,5, Fei Wang^1,3,4, Ping Hai^2,3, Fang Wang¹, Yin-Dong Fang³, Wen-Yong Xiong¹, Ji-Kai Liu^1,6

1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, People's Republic of China;
2. Department of Chemical Engineering, Yibin University, Yibin 644000, People's Republic of China;
3. BioBioPha Co., Ltd, Kunming 650201, People's Republic of China;
4. Graduate University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China;
5. Yunnan University, Kunming 650091, People's Republic of China;
6. School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China

收稿日期:2016-08-30 修回日期:2016-09-28 出版日期:2016-10-24 发布日期:2018-02-08
通讯作者: Wen-Yong Xiong,e-mail:xiong.wenyong@mail.kib.ac.cn;Ji-Kai Liu,e-mail:jkliu@mail.kib.ac.cn

Clerodane Diterpenoids with Anti-hyperglycemic Activity from Tinospora crispa

Yuan Gao^1,2,3, Yan-Fen Niu^1,4,5, Fei Wang^1,3,4, Ping Hai^2,3, Fang Wang¹, Yin-Dong Fang³, Wen-Yong Xiong¹, Ji-Kai Liu^1,6

1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, People's Republic of China;
2. Department of Chemical Engineering, Yibin University, Yibin 644000, People's Republic of China;
3. BioBioPha Co., Ltd, Kunming 650201, People's Republic of China;
4. Graduate University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China;
5. Yunnan University, Kunming 650091, People's Republic of China;
6. School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China

Received:2016-08-30 Revised:2016-09-28 Online:2016-10-24 Published:2018-02-08

摘要/Abstract

摘要： Four new clerodane diterpenoids, tinosporols A-C (2-4) and tinosporoside A (5), together with six known analogues were isolated from the vines of Tinospora crispa. Their structures were established by extensive spectroscopic analysis. The relative configuration at C-12 in the known diterpenoid borapetoside E (1), the major component of the plant, was firstly established with the aid of molecular model. Compound 1 significantly reduced serum glucose levels at dosedependent manners in alloxan-induced hyperglycemic mice and db/db type 2 diabetic mice.

关键词: Anti-hyperglycemia

Abstract: Four new clerodane diterpenoids, tinosporols A-C (2-4) and tinosporoside A (5), together with six known analogues were isolated from the vines of Tinospora crispa. Their structures were established by extensive spectroscopic analysis. The relative configuration at C-12 in the known diterpenoid borapetoside E (1), the major component of the plant, was firstly established with the aid of molecular model. Compound 1 significantly reduced serum glucose levels at dosedependent manners in alloxan-induced hyperglycemic mice and db/db type 2 diabetic mice.

Key words: Anti-hyperglycemia

Yuan Gao, Yan-Fen Niu, Fei Wang, Ping Hai, Fang Wang, Yin-Dong Fang, Wen-Yong Xiong, Ji-Kai Liu. Clerodane Diterpenoids with Anti-hyperglycemic Activity from Tinospora crispa[J]. 应用天然产物, 2016, 6(5): 247-255.

Clerodane Diterpenoids with Anti-hyperglycemic Activity from Tinospora crispa

Clerodane Diterpenoids with Anti-hyperglycemic Activity from Tinospora crispa

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