Lycopodine-Type Alkaloids from Lycopodium japonicum

doi:10.1007/s13659-014-0027-1

应用天然产物 ›› 2014, Vol. 4 ›› Issue (4): 213-219.DOI: 10.1007/s13659-014-0027-1

• Original article • 上一篇下一篇

Lycopodine-Type Alkaloids from Lycopodium japonicum

Juan He, Xing-De Wu, Fei Liu, Yu-Cheng Liu, Li-Yan Peng, Yu Zhao, Xiao Cheng, Huai-Rong Luo, Qin-Shi Zhao

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China

收稿日期:2014-05-11 修回日期:2014-05-11 出版日期:2014-08-24 发布日期:2018-02-11
通讯作者: Qin-Shi Zhao,e-mail:qinshizhao@mail.kib.ac.cn
基金资助:
This work was financially supported by the National Natural Science Foundation of China(Nos. 90813004 and U0932602) and the National Basic Research Program of China(973 Program No. 2011CB915503).

Lycopodine-Type Alkaloids from Lycopodium japonicum

Juan He, Xing-De Wu, Fei Liu, Yu-Cheng Liu, Li-Yan Peng, Yu Zhao, Xiao Cheng, Huai-Rong Luo, Qin-Shi Zhao

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China

Received:2014-05-11 Revised:2014-05-11 Online:2014-08-24 Published:2018-02-11
Supported by:
This work was financially supported by the National Natural Science Foundation of China(Nos. 90813004 and U0932602) and the National Basic Research Program of China(973 Program No. 2011CB915503).

摘要/Abstract

摘要： Three new lycopodine-type alkaloids, 4α-hydroxyanhydrolycodoline(1), 4α, 6α-dihydroxyanhydrolycodoline(2), and 6-epi-8β-acetoxylycoclavine(3), and an artifact, lycoposerramine G nitrate(4), along with seventeen related known compounds, were isolated from the club moss Lycopodium japonicum Thunb. ex Murray(Lycopodiaceae). Their structures were elucidated by extensive spectroscopic methods as well as X-ray analysis. Compounds 1-4 were evaluated for their acetylcholine esterase inhibitory activity.

关键词: Lycopodium japonicum, Lycopodine-type alkaloids, 4α-Hydroxyanhydrolycodoline, 4α, 6α-Dihydroxyanhydrolycodoline, 6-epi-8β-Acetoxylycoclavine, Lycoposerramine G nitr

Abstract: Three new lycopodine-type alkaloids, 4α-hydroxyanhydrolycodoline(1), 4α, 6α-dihydroxyanhydrolycodoline(2), and 6-epi-8β-acetoxylycoclavine(3), and an artifact, lycoposerramine G nitrate(4), along with seventeen related known compounds, were isolated from the club moss Lycopodium japonicum Thunb. ex Murray(Lycopodiaceae). Their structures were elucidated by extensive spectroscopic methods as well as X-ray analysis. Compounds 1-4 were evaluated for their acetylcholine esterase inhibitory activity.

Key words: Lycopodium japonicum, Lycopodine-type alkaloids, 4α-Hydroxyanhydrolycodoline, 4α, 6α-Dihydroxyanhydrolycodoline, 6-epi-8β-Acetoxylycoclavine, Lycoposerramine G nitr

Juan He, Xing-De Wu, Fei Liu, Yu-Cheng Liu, Li-Yan Peng, Yu Zhao, Xiao Cheng, Huai-Rong Luo, Qin-Shi Zhao. Lycopodine-Type Alkaloids from Lycopodium japonicum[J]. 应用天然产物, 2014, 4(4): 213-219.

Juan He, Xing-De Wu, Fei Liu, Yu-Cheng Liu, Li-Yan Peng, Yu Zhao, Xiao Cheng, Huai-Rong Luo, Qin-Shi Zhao. Lycopodine-Type Alkaloids from Lycopodium japonicum[J]. Natural Products and Bioprospecting, 2014, 4(4): 213-219.

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Lycopodine-Type Alkaloids from Lycopodium japonicum

Lycopodine-Type Alkaloids from Lycopodium japonicum

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