整合生物学期刊网

应用天然产物 ›› 2014, Vol. 4 ›› Issue (4): 207-211.DOI: 10.1007/s13659-014-0032-4

• Original article • 上一篇    下一篇

Three New Humulane Sesquiterpenes from Cultures of the Fungus Antrodiella albocinnamomea

Zi-Ming Chen1, Qiong-Ying Fan2, Xia Yin1, Xiao-Yan Yang1, Zheng-Hui Li1, Tao Feng1, Ji-Kai Liu1   

  1. 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, 132#Lanhei Road, Heilongtan, Kunming 650201, Yunnan, People's Republic of China;
    2. College of Life Science, Hebei Normal University, Shijiazhuang 050024, People's Republic of China;
    2. College of Life Science, Hebei Normal University, Shijiazhuang 050024, People's Republic of China
  • 收稿日期:2014-06-02 修回日期:2014-07-02 出版日期:2014-08-24 发布日期:2018-02-11
  • 通讯作者: Ji-Kai Liu,e-mail:jkliu@mail.kib.ac.cn
  • 基金资助:
    This project was financially supported by National Natural Science Foundation of China(U1132607, 81373289, 81102346) and Youth Innovation Promotion Association of CAS(2011312D11019).

Three New Humulane Sesquiterpenes from Cultures of the Fungus Antrodiella albocinnamomea

Zi-Ming Chen1, Qiong-Ying Fan2, Xia Yin1, Xiao-Yan Yang1, Zheng-Hui Li1, Tao Feng1, Ji-Kai Liu1   

  1. 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, 132#Lanhei Road, Heilongtan, Kunming 650201, Yunnan, People's Republic of China;
    2. College of Life Science, Hebei Normal University, Shijiazhuang 050024, People's Republic of China;
    2. College of Life Science, Hebei Normal University, Shijiazhuang 050024, People's Republic of China
  • Received:2014-06-02 Revised:2014-07-02 Online:2014-08-24 Published:2018-02-11
  • Supported by:
    This project was financially supported by National Natural Science Foundation of China(U1132607, 81373289, 81102346) and Youth Innovation Promotion Association of CAS(2011312D11019).

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摘要： Three new humulane-type sesquiterpenes, antrodols A-C(1-3), were isolated from cultures of the fungus Antrodiella albocinnamomea. Their structures were elucidated on the basis of extensive spectroscopic analysis. Antrodols A-C(1-3) are first examples of humulane-type sesquiterpenes isolated from cultures of higher fungi, and antrodol A(1) was the first report of humulane-type sesquiterpene with a methyl rearranged at C-3. All compounds were evaluated in the enzyme inhibition assay against two protein-tyrosine phosphatases(PTPs):MEG2 and PTP1Bc.

关键词: Antrodiella albocinnamomea, Humulane-type sesquiterpenes, Protein tyrosine phosphatase inhibitory activity

Abstract: Three new humulane-type sesquiterpenes, antrodols A-C(1-3), were isolated from cultures of the fungus Antrodiella albocinnamomea. Their structures were elucidated on the basis of extensive spectroscopic analysis. Antrodols A-C(1-3) are first examples of humulane-type sesquiterpenes isolated from cultures of higher fungi, and antrodol A(1) was the first report of humulane-type sesquiterpene with a methyl rearranged at C-3. All compounds were evaluated in the enzyme inhibition assay against two protein-tyrosine phosphatases(PTPs):MEG2 and PTP1Bc.

Key words: Antrodiella albocinnamomea, Humulane-type sesquiterpenes, Protein tyrosine phosphatase inhibitory activity

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