Sterols and Terpenoids from Viburnum odoratissimum

doi:10.1007/s13659-014-0021-7

应用天然产物 ›› 2014, Vol. 4 ›› Issue (3): 175-180.DOI: 10.1007/s13659-014-0021-7

• Original article • 上一篇下一篇

Sterols and Terpenoids from Viburnum odoratissimum

Jun-Zeng Ma^1,2, Xing-Wei Yang², Jing-Jing Zhang², Xia Liu², Li-Lan Deng¹, Xiao-Ling Shen³, Gang Xu²

1. Southwest Forestry University, Kunming 650224, People's Republic of China;
2. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
3. Laboratory of Chinese Herbal Drug Discovery, Tropical Medicine Institute, Guangzhou University of Chinese Medicine, Guangzhou 510405, People's Republic of China

收稿日期:2014-03-18 修回日期:2014-04-23 出版日期:2014-06-24 发布日期:2018-02-11
通讯作者: Xiao-Ling Shen,e-mail:xlshen66@126.com;Gang Xu,e-mail:xugang008@mail.kib.ac.cn
基金资助:
The work was financially supported by the foundations from NSFC(20972167), the Young Academic Leader Raising Foundation of Yunnan Province(No. 2009CI073), and the foundation from CAS to Dr G. Xu.

Sterols and Terpenoids from Viburnum odoratissimum

Jun-Zeng Ma^1,2, Xing-Wei Yang², Jing-Jing Zhang², Xia Liu², Li-Lan Deng¹, Xiao-Ling Shen³, Gang Xu²

1. Southwest Forestry University, Kunming 650224, People's Republic of China;
2. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
3. Laboratory of Chinese Herbal Drug Discovery, Tropical Medicine Institute, Guangzhou University of Chinese Medicine, Guangzhou 510405, People's Republic of China

Received:2014-03-18 Revised:2014-04-23 Online:2014-06-24 Published:2018-02-11
Supported by:
The work was financially supported by the foundations from NSFC(20972167), the Young Academic Leader Raising Foundation of Yunnan Province(No. 2009CI073), and the foundation from CAS to Dr G. Xu.

摘要/Abstract

摘要： A new stigmasterol type natural product, viburodorol A(1), along with eleven known sterols and terpenoids(2-12), were isolated from the aerial parts of Viburnum odoratissimum. The structure of 1 was elucidated on the basis of comprehensive spectroscopic analysis. It's noteworthy that compound 2, the major constituent of this plant, can significantly stimulate glucose absorption in insulin resistant HepG2 cells without affecting cell viability. Furthermore, this compound can also restore the glucose absorption in DXMS-induced insulin resistant 3T3-L1 cells.

关键词: Viburnum odoratissimum, Insulin sensitizing activity, 6α-Hydroxy-lup-20(29)-en-3-on-28-oic acid, Viburodorol A

Abstract: A new stigmasterol type natural product, viburodorol A(1), along with eleven known sterols and terpenoids(2-12), were isolated from the aerial parts of Viburnum odoratissimum. The structure of 1 was elucidated on the basis of comprehensive spectroscopic analysis. It's noteworthy that compound 2, the major constituent of this plant, can significantly stimulate glucose absorption in insulin resistant HepG2 cells without affecting cell viability. Furthermore, this compound can also restore the glucose absorption in DXMS-induced insulin resistant 3T3-L1 cells.

Key words: Viburnum odoratissimum, Insulin sensitizing activity, 6α-Hydroxy-lup-20(29)-en-3-on-28-oic acid, Viburodorol A

Jun-Zeng Ma, Xing-Wei Yang, Jing-Jing Zhang, Xia Liu, Li-Lan Deng, Xiao-Ling Shen, Gang Xu. Sterols and Terpenoids from Viburnum odoratissimum[J]. 应用天然产物, 2014, 4(3): 175-180.

Jun-Zeng Ma, Xing-Wei Yang, Jing-Jing Zhang, Xia Liu, Li-Lan Deng, Xiao-Ling Shen, Gang Xu. Sterols and Terpenoids from Viburnum odoratissimum[J]. Natural Products and Bioprospecting, 2014, 4(3): 175-180.

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Sterols and Terpenoids from Viburnum odoratissimum

Sterols and Terpenoids from Viburnum odoratissimum

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