Chemical constituents from the aerial parts of Musella lasiocarpa

doi:10.1007/s13659-011-0007-7

应用天然产物 ›› 2011, Vol. 1 ›› Issue (1): 41-47.DOI: 10.1007/s13659-011-0007-7

Chemical constituents from the aerial parts of Musella lasiocarpa

Liao-Bin DONG^a,b, Juan HE^a, Xing-Yao LI^a,b, Xing-De WU^a,b, Xu DENG^a,b, Gang XU^a, Li-Yan PENG^a, Yu ZHAO^a, Yan LI^a, Xun GONG^a, Qin-Shi ZHAO^a

a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
b Graduate University of Chinese Academy of Sciences, Beijing 100039, China

收稿日期:2011-07-03 修回日期:2011-08-26 出版日期:2011-01-29 发布日期:2017-11-10
通讯作者: Qin-Shi ZHAO,E-mail:qinshizhao@mail.kib.ac.cn
基金资助:
This work was financially supported by the National Basic Research Program of China(973 Program No. 2009CB522303 and No. 2011CB915503), the NSFC(No. U0932602), the National Natural Science Foundation of China(No. 90813004), and the State Key Laboratory of Phytochemistry and Plant Resources in West China(No. P2010-ZZ05).

Chemical constituents from the aerial parts of Musella lasiocarpa

Liao-Bin DONG^a,b, Juan HE^a, Xing-Yao LI^a,b, Xing-De WU^a,b, Xu DENG^a,b, Gang XU^a, Li-Yan PENG^a, Yu ZHAO^a, Yan LI^a, Xun GONG^a, Qin-Shi ZHAO^a

a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
b Graduate University of Chinese Academy of Sciences, Beijing 100039, China

Received:2011-07-03 Revised:2011-08-26 Online:2011-01-29 Published:2017-11-10
Supported by:
This work was financially supported by the National Basic Research Program of China(973 Program No. 2009CB522303 and No. 2011CB915503), the NSFC(No. U0932602), the National Natural Science Foundation of China(No. 90813004), and the State Key Laboratory of Phytochemistry and Plant Resources in West China(No. P2010-ZZ05).

摘要/Abstract

摘要： Phytochemical investigation of the aerial parts of the monotypic plant, Musella lasiocarpa, led to the isolation of four rare bicyclic diarylheptanoids, musellarins B-E(2-5), two new phenylphenalenones, 2-methoxy-9-(3', 4'-dihydroxyphenyl)-1H-phenalen-1-one(9), 2-methoxy-9-(3'-methoxy-4'-hydroxyphenyl)-1H-phenalen-1-one(10), a new acenaphtylene derivative, trans-(1S, 2S)-3-(4'-methoxyphenyl)-acenaphthene-1, 2-diol(13), and two new sucrose esters, 1, 2', 3', 4', 6'-O-pentaacetyl-3-O-trans-p-coumaroylsucrose(16), 1, 2', 3', 4', 6'-O-pentaacetyl-3-O-cis-p-coumaroylsucrose(17), together with nine known compounds. In addition,(4E, 6E)-1-(3', 4'-dihydroxyphenyl)-7-(4"-hydroxyphenyl)-hepta-4, 6-dien-3-one(15) was isolated for the first time from a natural source. The structures of new compounds were elucidated by analysis of their spectroscopic data. Compounds 2, 6, 8-10, 12, and 14 were cytotoxic toward several of the human tumor cell lines(HL-60, SMMC-7721, A-549, MCF-7, and SW480). Of these, the new compound 9 was the most potent one, with IC₅₀ values of 5.8, 10.3, 6.3, 3.3, and 2.3 μM, respectively.

关键词: monotypic, diarylheptanoid, phenylphenalenone, acenaphtylene, sucrose ester, Musella lasiocarpa

Abstract: Phytochemical investigation of the aerial parts of the monotypic plant, Musella lasiocarpa, led to the isolation of four rare bicyclic diarylheptanoids, musellarins B-E(2-5), two new phenylphenalenones, 2-methoxy-9-(3', 4'-dihydroxyphenyl)-1H-phenalen-1-one(9), 2-methoxy-9-(3'-methoxy-4'-hydroxyphenyl)-1H-phenalen-1-one(10), a new acenaphtylene derivative, trans-(1S, 2S)-3-(4'-methoxyphenyl)-acenaphthene-1, 2-diol(13), and two new sucrose esters, 1, 2', 3', 4', 6'-O-pentaacetyl-3-O-trans-p-coumaroylsucrose(16), 1, 2', 3', 4', 6'-O-pentaacetyl-3-O-cis-p-coumaroylsucrose(17), together with nine known compounds. In addition,(4E, 6E)-1-(3', 4'-dihydroxyphenyl)-7-(4"-hydroxyphenyl)-hepta-4, 6-dien-3-one(15) was isolated for the first time from a natural source. The structures of new compounds were elucidated by analysis of their spectroscopic data. Compounds 2, 6, 8-10, 12, and 14 were cytotoxic toward several of the human tumor cell lines(HL-60, SMMC-7721, A-549, MCF-7, and SW480). Of these, the new compound 9 was the most potent one, with IC₅₀ values of 5.8, 10.3, 6.3, 3.3, and 2.3 μM, respectively.

Key words: monotypic, diarylheptanoid, phenylphenalenone, acenaphtylene, sucrose ester, Musella lasiocarpa

Liao-Bin DONG, Juan HE, Xing-Yao LI, Xing-De WU, Xu DENG, Gang XU, Li-Yan PENG, Yu ZHAO, Yan LI, Xun GONG, Qin-Shi ZHAO. Chemical constituents from the aerial parts of Musella lasiocarpa[J]. 应用天然产物, 2011, 1(1): 41-47.

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Chemical constituents from the aerial parts of Musella lasiocarpa

Chemical constituents from the aerial parts of Musella lasiocarpa

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