Natural compounds proposed for the management of non-alcoholic fatty liver disease

doi:10.1007/s13659-024-00445-z

应用天然产物 ›› 2024, Vol. 14 ›› Issue (3): 24-24.DOI: 10.1007/s13659-024-00445-z

Natural compounds proposed for the management of non-alcoholic fatty liver disease

Théodora Merenda¹, Florian Juszczak², Elisabeth Ferier^2,3, Pierre Duez³, Stéphanie Patris¹, Anne-Émilie Declèves², Amandine Nachtergael³

1 Unit of Clinical Pharmacy, Research Institute for Health Sciences and Technology, University of Mons(UMONS), Mons, Belgium;
2 Department of Metabolic and Molecular Biochemistry, Research Institute for Health Sciences and Technology, University of Mons(UMONS), Mons, Belgium;
3 Unit of Therapeutic Chemistry and Pharmacognosy, Research Institute for Health Sciences and Technology, University of Mons(UMONS), Mons, Belgium

收稿日期:2024-01-16 发布日期:2024-06-14
通讯作者: Amandine Nachtergael,E-mail:amandine.nachtergael@umons.ac.be
基金资助:
T. Merenda is supported by a doctoral fellowship from “UMONS-Les Amis des Aveugles et des Malvoyants” Academic chair. This work was partly funded by the multidisciplinary inter-institute “Health-Bioscience” projects 2020—QUINOACT.

Natural compounds proposed for the management of non-alcoholic fatty liver disease

Théodora Merenda¹, Florian Juszczak², Elisabeth Ferier^2,3, Pierre Duez³, Stéphanie Patris¹, Anne-Émilie Declèves², Amandine Nachtergael³

1 Unit of Clinical Pharmacy, Research Institute for Health Sciences and Technology, University of Mons(UMONS), Mons, Belgium;
2 Department of Metabolic and Molecular Biochemistry, Research Institute for Health Sciences and Technology, University of Mons(UMONS), Mons, Belgium;
3 Unit of Therapeutic Chemistry and Pharmacognosy, Research Institute for Health Sciences and Technology, University of Mons(UMONS), Mons, Belgium

Received:2024-01-16 Published:2024-06-14
Contact: Amandine Nachtergael,E-mail:amandine.nachtergael@umons.ac.be
Supported by:
T. Merenda is supported by a doctoral fellowship from “UMONS-Les Amis des Aveugles et des Malvoyants” Academic chair. This work was partly funded by the multidisciplinary inter-institute “Health-Bioscience” projects 2020—QUINOACT.

摘要/Abstract

摘要： Although non-alcoholic fatty liver disease (NAFLD) presents as an intricate condition characterized by a growing prevalence, the often-recommended lifestyle interventions mostly lack high-level evidence of efficacy and there are currently no effective drugs proposed for this indication. The present review delves into NAFLD pathology, its diverse underlying physiopathological mechanisms and the available in vitro, in vivo, and clinical evidence regarding the use of natural compounds for its management, through three pivotal targets (oxidative stress, cellular inflammation, and insulin resistance). The promising perspectives that natural compounds offer for NAFLD management underscore the need for additional clinical and lifestyle intervention trials. Encouraging further research will contribute to establishing more robust evidence and practical recommendations tailored to patients with varying NAFLD grades.

关键词: Non-alcoholic fatty liver disease, Natural compound, Sylimarin, Curcumin, Biochanin A, Oleanolic acid, Ginsenoside K, 6-Gingerol, Naringenin, Hesperidin, Chenopodium quinoa

Abstract: Although non-alcoholic fatty liver disease (NAFLD) presents as an intricate condition characterized by a growing prevalence, the often-recommended lifestyle interventions mostly lack high-level evidence of efficacy and there are currently no effective drugs proposed for this indication. The present review delves into NAFLD pathology, its diverse underlying physiopathological mechanisms and the available in vitro, in vivo, and clinical evidence regarding the use of natural compounds for its management, through three pivotal targets (oxidative stress, cellular inflammation, and insulin resistance). The promising perspectives that natural compounds offer for NAFLD management underscore the need for additional clinical and lifestyle intervention trials. Encouraging further research will contribute to establishing more robust evidence and practical recommendations tailored to patients with varying NAFLD grades.

Key words: Non-alcoholic fatty liver disease, Natural compound, Sylimarin, Curcumin, Biochanin A, Oleanolic acid, Ginsenoside K, 6-Gingerol, Naringenin, Hesperidin, Chenopodium quinoa

Théodora Merenda, Florian Juszczak, Elisabeth Ferier, Pierre Duez, Stéphanie Patris, Anne-Émilie Declèves, Amandine Nachtergael. Natural compounds proposed for the management of non-alcoholic fatty liver disease[J]. 应用天然产物, 2024, 14(3): 24-24.

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Natural compounds proposed for the management of non-alcoholic fatty liver disease

Natural compounds proposed for the management of non-alcoholic fatty liver disease

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