Indonesian marine and its medicinal contribution

doi:10.1007/s13659-023-00403-1

应用天然产物 ›› 2023, Vol. 13 ›› Issue (5): 38-38.DOI: 10.1007/s13659-023-00403-1

Indonesian marine and its medicinal contribution

Ari Satia Nugraha^1,5,10, Lilla Nur Firli¹, Dinar Mutia Rani¹, Ayunda Hidayatiningsih¹, Nadya Dini Lestari¹, Hendris Wongso^2,3, Kustiariyah Tarman⁴, Ayu Christien Rahaweman⁵, Jeprianto Manurung⁶, Ni Putu Ariantari⁷, Adelfia Papu⁸, Masteria Yunovilsa Putra⁹, Antonius Nugraha Widhi Pratama¹, Ludger A. Wessjohann⁵, Paul A. Keller¹⁰

1. Drug Utilisation and Discovery Research Group, Faculty of Pharmacy, Universitas Jember, Jember, 68121, Indonesia;
2. Research Center for Radioisotope, Radiopharmaceutical, and Biodosimetry Technology, Research Organization for Nuclear Energy, National Research and Innovation Agency, Puspiptek, Banten, 15314, Indonesia;
3. Research Collaboration Center for Theranostic Radiopharmaceuticals, National Research and Innovation Agency, J1. Raya Bandung-Sumedang KM 21, Sumedang, 45363, Indonesia;
4. Department of Aquatic Product Technology, Faculty of Fisheries and Marine Sciences;
and Division of Marine Biotechnology, Centre for Coastal and Marine Resources Studies (CCMRS), IPB University, Bogor, 16680, Indonesia;
5. Leibniz Institute Für Pflanzenbiochemie, Weinberg 3, 06120, Halle (Saale), Germany;
6. German Centre for Integrative Biodiversity Research (iDiv) Halle-Jena-Leipzig, Puschstrasse 4, 04103, Leipzig, Germany;
7. Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Udayana University, Badung, Bali, 80361, Indonesia;
8. Biology Department, Faculty of Mathematics and Natural Sciences, Sam Ratulangi University, Manado, 95115, Indonesia;
9. Vaccine and Drug Research Center, National Research and Innovation Agency, Cibinong, Jawa Barat, 16911, Indonesia;
10. School of Chemistry and Molecular Biosciences, Molecular Horizons, University of Wollongong, Wollongong, NSW, 2522, Australia

收稿日期:2023-07-14 出版日期:2023-10-24 发布日期:2023-11-03
通讯作者: Ari Satia Nugraha,E-mail:arisatia@unej.ac.id
基金资助:
A.S.N, K.T., A.C.R., J.M., A.P., M.Y.P., N.P.A. thank to Deutscher Akademischer Austauschdienst (DAAD) for alumni networking support.

Indonesian marine and its medicinal contribution

1. Drug Utilisation and Discovery Research Group, Faculty of Pharmacy, Universitas Jember, Jember, 68121, Indonesia;
2. Research Center for Radioisotope, Radiopharmaceutical, and Biodosimetry Technology, Research Organization for Nuclear Energy, National Research and Innovation Agency, Puspiptek, Banten, 15314, Indonesia;
3. Research Collaboration Center for Theranostic Radiopharmaceuticals, National Research and Innovation Agency, J1. Raya Bandung-Sumedang KM 21, Sumedang, 45363, Indonesia;
4. Department of Aquatic Product Technology, Faculty of Fisheries and Marine Sciences;
and Division of Marine Biotechnology, Centre for Coastal and Marine Resources Studies (CCMRS), IPB University, Bogor, 16680, Indonesia;
5. Leibniz Institute Für Pflanzenbiochemie, Weinberg 3, 06120, Halle (Saale), Germany;
6. German Centre for Integrative Biodiversity Research (iDiv) Halle-Jena-Leipzig, Puschstrasse 4, 04103, Leipzig, Germany;
7. Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Udayana University, Badung, Bali, 80361, Indonesia;
8. Biology Department, Faculty of Mathematics and Natural Sciences, Sam Ratulangi University, Manado, 95115, Indonesia;
9. Vaccine and Drug Research Center, National Research and Innovation Agency, Cibinong, Jawa Barat, 16911, Indonesia;
10. School of Chemistry and Molecular Biosciences, Molecular Horizons, University of Wollongong, Wollongong, NSW, 2522, Australia

Received:2023-07-14 Online:2023-10-24 Published:2023-11-03
Contact: Ari Satia Nugraha,E-mail:arisatia@unej.ac.id
Supported by:
A.S.N, K.T., A.C.R., J.M., A.P., M.Y.P., N.P.A. thank to Deutscher Akademischer Austauschdienst (DAAD) for alumni networking support.

摘要/Abstract

摘要： The archipelagic country of Indonesia is populated by the densest marine biodiversity in the world which has created strong global interest and is valued by both Indigenous and European settlements for different purposes. Nearly 1000 chemicals have been extracted and identified. In this review, a systematic data curation was employed to collate bioprospecting related manuscripts providing a comprehensive directory based on publications from 1988 to 2022. Findings with significant pharmacological activities are further discussed through a scoping data collection. This review discusses macroorganisms (Sponges, Ascidian, Gorgonians, Algae, Mangrove) and microorganism (Bacteria and Fungi) and highlights significant discoveries, including a potent microtubule stabilizer laulimalide from Hyattella sp., a prospective doxorubicin complement papuamine alkaloid from Neopetrosia cf exigua, potent antiplasmodial manzamine A from Acanthostrongylophora ingens, the highly potent anti trypanosomal manadoperoxide B from Plakortis cfr. Simplex, mRNA translation disrupter hippuristanol from Briareum sp, and the anti-HIV-1 (+)-8-hydroxymanzamine A isolated from Acanthostrongylophora sp. Further, some potent antibacterial extracts were also found from a limited biomass of bacteria cultures. Although there are currently no examples of commercial drugs from the Indonesian marine environment, this review shows the molecular diversity present and with the known understudied biodiversity, reveals great promise for future studies and outcomes.

关键词: Indonesian marine, Laulimalide, Papuamine, Manzamine A, Manadoperoxide B, Hippuristanol, (+)-8-Hydroxymanzamine A

Abstract: The archipelagic country of Indonesia is populated by the densest marine biodiversity in the world which has created strong global interest and is valued by both Indigenous and European settlements for different purposes. Nearly 1000 chemicals have been extracted and identified. In this review, a systematic data curation was employed to collate bioprospecting related manuscripts providing a comprehensive directory based on publications from 1988 to 2022. Findings with significant pharmacological activities are further discussed through a scoping data collection. This review discusses macroorganisms (Sponges, Ascidian, Gorgonians, Algae, Mangrove) and microorganism (Bacteria and Fungi) and highlights significant discoveries, including a potent microtubule stabilizer laulimalide from Hyattella sp., a prospective doxorubicin complement papuamine alkaloid from Neopetrosia cf exigua, potent antiplasmodial manzamine A from Acanthostrongylophora ingens, the highly potent anti trypanosomal manadoperoxide B from Plakortis cfr. Simplex, mRNA translation disrupter hippuristanol from Briareum sp, and the anti-HIV-1 (+)-8-hydroxymanzamine A isolated from Acanthostrongylophora sp. Further, some potent antibacterial extracts were also found from a limited biomass of bacteria cultures. Although there are currently no examples of commercial drugs from the Indonesian marine environment, this review shows the molecular diversity present and with the known understudied biodiversity, reveals great promise for future studies and outcomes.

Key words: Indonesian marine, Laulimalide, Papuamine, Manzamine A, Manadoperoxide B, Hippuristanol, (+)-8-Hydroxymanzamine A

Ari Satia Nugraha, Lilla Nur Firli, Dinar Mutia Rani, Ayunda Hidayatiningsih, Nadya Dini Lestari, Hendris Wongso, Kustiariyah Tarman, Ayu Christien Rahaweman, Jeprianto Manurung, Ni Putu Ariantari, Adelfia Papu, Masteria Yunovilsa Putra, Antonius Nugraha Widhi Pratama, Ludger A. Wessjohann, Paul A. Keller. Indonesian marine and its medicinal contribution[J]. 应用天然产物, 2023, 13(5): 38-38.

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Indonesian marine and its medicinal contribution

Indonesian marine and its medicinal contribution

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