Apatite phosphate doped by cobalt as hight efficient catalyst of multi-component synthesis of therapeutic spiropyrimidine compound

doi:10.1007/s13659-022-00359-8

应用天然产物 ›› 2022, Vol. 12 ›› Issue (5): 35-35.DOI: 10.1007/s13659-022-00359-8

• ORIGINAL ARTICLES • 上一篇

Apatite phosphate doped by cobalt as hight efficient catalyst of multi-component synthesis of therapeutic spiropyrimidine compound

Abdallah Rhihil², Youness Aichi¹, Mohamed Zahouily³, Sa?d Sebti¹, Mohamed El Guendouzi¹

1 Laboratory of Chemistry Physics Materials and Catalysis (LCPMC), Faculty of Sciences Ben M'sik of Casablanca, Hassan II University of Casablanca, Casablanca, Morocco;
2 Financial Engineering, Governance and Development Laboratory, National School of Business and Management of Casablanca, Hassan II University of Casablanca, Casablanca, Morocco;
3 Laboratory of Materials, Catalysis and Valorization of Natural Resources, Faculty of Sciences and Technology of Mohammedia, Hassan II University of Casablanca, Casablanca, Morocco

收稿日期:2022-07-16 修回日期:2022-09-04 出版日期:2022-10-24 发布日期:2022-10-12
通讯作者: Abdallah Rhihil,E-mail:a.rhihil@encgcasa.ma

Apatite phosphate doped by cobalt as hight efficient catalyst of multi-component synthesis of therapeutic spiropyrimidine compound

Abdallah Rhihil², Youness Aichi¹, Mohamed Zahouily³, Sa?d Sebti¹, Mohamed El Guendouzi¹

1 Laboratory of Chemistry Physics Materials and Catalysis (LCPMC), Faculty of Sciences Ben M'sik of Casablanca, Hassan II University of Casablanca, Casablanca, Morocco;
2 Financial Engineering, Governance and Development Laboratory, National School of Business and Management of Casablanca, Hassan II University of Casablanca, Casablanca, Morocco;
3 Laboratory of Materials, Catalysis and Valorization of Natural Resources, Faculty of Sciences and Technology of Mohammedia, Hassan II University of Casablanca, Casablanca, Morocco

Received:2022-07-16 Revised:2022-09-04 Online:2022-10-24 Published:2022-10-12
Contact: Abdallah Rhihil,E-mail:a.rhihil@encgcasa.ma

摘要/Abstract

摘要： Spiropyrimidines vanquish a significant situation in the field of heterocyclic chemistry, they are broadly utilized as an antibacterial, an inhibitor of multidrug opposition, or an antiplatelet and antithrombotic drug. Phosphate, the principal Moroccan mineral wealth occupies a vital spot in the economic sector and its valuation is a goal continually looked for. Among the conceivable outcomes of valorization, its utilization in heterogeneous catalysis which thought about an exceptionally encouraging new way. In this context, the focus on the reaction of the synthesis of spiropyrimidine, catalyzed by natural phosphate (NP) and by fluoroapatite (Fap), are used alone or doped by cobalt. These phosphate catalysts were characterized by XRD, IR and SEM, while the synthesized spiropyrimidine was identified by IR, GC–MS and NMR. The obtained yield with fluorapatite doped by cobalt (Co/Fap), at room temperature in ethanol is very high and shows a high impact performance induced by a synergistic effect compared to that of NP alone.

关键词: Spiropyrimidine, Natural phosphate, Co/Fap, Heterogeneous catalysis, Multicomponent reaction

Abstract: Spiropyrimidines vanquish a significant situation in the field of heterocyclic chemistry, they are broadly utilized as an antibacterial, an inhibitor of multidrug opposition, or an antiplatelet and antithrombotic drug. Phosphate, the principal Moroccan mineral wealth occupies a vital spot in the economic sector and its valuation is a goal continually looked for. Among the conceivable outcomes of valorization, its utilization in heterogeneous catalysis which thought about an exceptionally encouraging new way. In this context, the focus on the reaction of the synthesis of spiropyrimidine, catalyzed by natural phosphate (NP) and by fluoroapatite (Fap), are used alone or doped by cobalt. These phosphate catalysts were characterized by XRD, IR and SEM, while the synthesized spiropyrimidine was identified by IR, GC–MS and NMR. The obtained yield with fluorapatite doped by cobalt (Co/Fap), at room temperature in ethanol is very high and shows a high impact performance induced by a synergistic effect compared to that of NP alone.

Key words: Spiropyrimidine, Natural phosphate, Co/Fap, Heterogeneous catalysis, Multicomponent reaction

Abdallah Rhihil, Youness Aichi, Mohamed Zahouily, Sa?d Sebti, Mohamed El Guendouzi. Apatite phosphate doped by cobalt as hight efficient catalyst of multi-component synthesis of therapeutic spiropyrimidine compound[J]. 应用天然产物, 2022, 12(5): 35-35.

Apatite phosphate doped by cobalt as hight efficient catalyst of multi-component synthesis of therapeutic spiropyrimidine compound

Apatite phosphate doped by cobalt as hight efficient catalyst of multi-component synthesis of therapeutic spiropyrimidine compound

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 0

编辑推荐

Metrics

本文评价