Isoprenylated Flavonoids as Cav3.1 Low Voltage-Gated Ca2+ Channel Inhibitors from Salvia digitaloides

doi:10.1007/s13659-021-00307-y

应用天然产物 ›› 2021, Vol. 11 ›› Issue (6): 671-678.DOI: 10.1007/s13659-021-00307-y

• ORIGINAL ARTICLES • 上一篇下一篇

Isoprenylated Flavonoids as Ca_v3.1 Low Voltage-Gated Ca²⁺ Channel Inhibitors from Salvia digitaloides

Jian-Jun Zhao^1,2, Song-Yu Li^1,2, Fan Xia¹, Ya-Li Hu^1,2, Yin Nian¹, Gang Xu¹

1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, People's Republic of China;
2 University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China

收稿日期:2021-03-12 出版日期:2021-12-24 发布日期:2021-12-10
通讯作者: Yin Nian, Gang Xu
基金资助:
The work was financially supported by the Foundation of Supported by National Natural Science Foundation of China (32070392 and 32070393) and the Second Tibetan Plateau Scientific Expedition and Research (STEP) program (2019QZKK0502-0303).

Isoprenylated Flavonoids as Ca_v3.1 Low Voltage-Gated Ca²⁺ Channel Inhibitors from Salvia digitaloides

Jian-Jun Zhao^1,2, Song-Yu Li^1,2, Fan Xia¹, Ya-Li Hu^1,2, Yin Nian¹, Gang Xu¹

1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, People's Republic of China;
2 University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China

Received:2021-03-12 Online:2021-12-24 Published:2021-12-10
Contact: Yin Nian, Gang Xu
Supported by:
The work was financially supported by the Foundation of Supported by National Natural Science Foundation of China (32070392 and 32070393) and the Second Tibetan Plateau Scientific Expedition and Research (STEP) program (2019QZKK0502-0303).

摘要/Abstract

摘要： Saldigones A-C (1, 3, 4), three new isoprenylated flavonoids with diverse flavanone, pterocarpan, and isoflavanone architectures, were characterized from the roots of Salvia digitaloides, together with a known isoprenylated flavanone (2). Notably, it's the first report of isoprenylated flavonoids from Salvia species. The structures of these isolates were elucidated by extensive spectroscopic analysis. All of the compounds were evaluated for their activities on Ca_v3.1 low voltage-gated Ca²⁺ channel (LVGCC), of which 2 strongly and dose-dependently inhibited Ca_v3.1 peak current.

关键词: Salvia digitaloides, Isoprenylated flavonoid, Ca_v3.1 low voltage-gated Ca²⁺ channel (LVGCC)

Abstract: Saldigones A-C (1, 3, 4), three new isoprenylated flavonoids with diverse flavanone, pterocarpan, and isoflavanone architectures, were characterized from the roots of Salvia digitaloides, together with a known isoprenylated flavanone (2). Notably, it's the first report of isoprenylated flavonoids from Salvia species. The structures of these isolates were elucidated by extensive spectroscopic analysis. All of the compounds were evaluated for their activities on Ca_v3.1 low voltage-gated Ca²⁺ channel (LVGCC), of which 2 strongly and dose-dependently inhibited Ca_v3.1 peak current.

Key words: Salvia digitaloides, Isoprenylated flavonoid, Ca_v3.1 low voltage-gated Ca²⁺ channel (LVGCC)

Jian-Jun Zhao, Song-Yu Li, Fan Xia, Ya-Li Hu, Yin Nian, Gang Xu. Isoprenylated Flavonoids as Ca_v3.1 Low Voltage-Gated Ca²⁺ Channel Inhibitors from Salvia digitaloides[J]. 应用天然产物, 2021, 11(6): 671-678.

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Isoprenylated Flavonoids as Ca_v3.1 Low Voltage-Gated Ca²⁺ Channel Inhibitors from Salvia digitaloides

Isoprenylated Flavonoids as Ca_v3.1 Low Voltage-Gated Ca²⁺ Channel Inhibitors from Salvia digitaloides

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