Setosphlides A-D, New Isocoumarin Derivatives from the Entomogenous Fungus Setosphaeria rostrate LGWB-10

doi:10.1007/s13659-020-00292-8

应用天然产物 ›› 2021, Vol. 11 ›› Issue (1): 137-142.DOI: 10.1007/s13659-020-00292-8

• ORIGINAL ARTICLES • 上一篇

Setosphlides A-D, New Isocoumarin Derivatives from the Entomogenous Fungus Setosphaeria rostrate LGWB-10

Wenbin Gao, Xiaoxia Wang, Fengli Chen, Chunqing Li, Fei Cao, Duqiang Luo

College of Life Science, Institute of Life Science and Green Development, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, Hebei University, Baoding 071002, China

收稿日期:2020-10-01 修回日期:2020-12-08 出版日期:2021-02-24 发布日期:2021-03-11
通讯作者: Fei Cao, Duqiang Luo
基金资助:
This work was funded by the National Natural Science Foundation of China (31672070) and National Key Research and Development Program of China (2017YFD0201400 and 2017YFD0201401), and the High Performance Computer Center of Hebei University.

Setosphlides A-D, New Isocoumarin Derivatives from the Entomogenous Fungus Setosphaeria rostrate LGWB-10

Wenbin Gao, Xiaoxia Wang, Fengli Chen, Chunqing Li, Fei Cao, Duqiang Luo

College of Life Science, Institute of Life Science and Green Development, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, Hebei University, Baoding 071002, China

Received:2020-10-01 Revised:2020-12-08 Online:2021-02-24 Published:2021-03-11
Contact: Fei Cao, Duqiang Luo
Supported by:
This work was funded by the National Natural Science Foundation of China (31672070) and National Key Research and Development Program of China (2017YFD0201400 and 2017YFD0201401), and the High Performance Computer Center of Hebei University.

摘要/Abstract

摘要： Investigation of the entomogenous fungus Setosphaeria rostrate LGWB-10 from Harmonia axyridis led to the isolation of four new isocoumarin derivatives, setosphlides A-D (1-4), and four known analogues (5-8). Their planar structures and the relative configurations were elucidated by comprehensive spectroscopic methods. The absolute configurations of isocoumarin nucleus for 1-4 were elucidated by their ECD spectra. The C-10 relative configurations for the pair of C-10 epimers (1 and 2) were established by comparing the magnitude of the computed ¹³C NMR chemical shifts (Δδ_calcd.) with the experimental ¹³C NMR values (Δδ_exp.) for the epimers. All of the isolated compounds (1-8) were evaluated for their cytotoxicities against four human tumor cell lines MCF-7, MGC-803, HeLa, and Huh-7.

关键词: Entomogenous fungus, Setosphaeria rostrate, Isocoumarin, Absolute configuration

Abstract: Investigation of the entomogenous fungus Setosphaeria rostrate LGWB-10 from Harmonia axyridis led to the isolation of four new isocoumarin derivatives, setosphlides A-D (1-4), and four known analogues (5-8). Their planar structures and the relative configurations were elucidated by comprehensive spectroscopic methods. The absolute configurations of isocoumarin nucleus for 1-4 were elucidated by their ECD spectra. The C-10 relative configurations for the pair of C-10 epimers (1 and 2) were established by comparing the magnitude of the computed ¹³C NMR chemical shifts (Δδ_calcd.) with the experimental ¹³C NMR values (Δδ_exp.) for the epimers. All of the isolated compounds (1-8) were evaluated for their cytotoxicities against four human tumor cell lines MCF-7, MGC-803, HeLa, and Huh-7.

Key words: Entomogenous fungus, Setosphaeria rostrate, Isocoumarin, Absolute configuration

Wenbin Gao, Xiaoxia Wang, Fengli Chen, Chunqing Li, Fei Cao, Duqiang Luo. Setosphlides A-D, New Isocoumarin Derivatives from the Entomogenous Fungus Setosphaeria rostrate LGWB-10[J]. 应用天然产物, 2021, 11(1): 137-142.

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Setosphlides A-D, New Isocoumarin Derivatives from the Entomogenous Fungus Setosphaeria rostrate LGWB-10

Setosphlides A-D, New Isocoumarin Derivatives from the Entomogenous Fungus Setosphaeria rostrate LGWB-10

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