Two New Phenolic Constituents from the Stems of Euphorbia griffithii

doi:10.1007/s13659-019-00223-2

应用天然产物 ›› 2019, Vol. 9 ›› Issue (6): 405-410.DOI: 10.1007/s13659-019-00223-2

• ORIGINAL ARTICLES • 上一篇下一篇

Two New Phenolic Constituents from the Stems of Euphorbia griffithii

Joseph Sakah Kaunda^1,2, Ying-Jun Zhang^1,3

1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China;
2 Graduate School of the Chinese Academy of Sciences, Beijing 100039, People's Republic of China;
3 Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China

收稿日期:2019-09-23 修回日期:2019-10-24 出版日期:2019-12-24 发布日期:2019-12-11
通讯作者: Ying-Jun Zhang
基金资助:
The authors appreciate the members of the analytical group at the State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, for measuring the spectroscopic data. This work was partially supported by Yunnan Key Laboratory of Natural Medicinal Chemistry (S2017-ZZ14).

Two New Phenolic Constituents from the Stems of Euphorbia griffithii

Joseph Sakah Kaunda^1,2, Ying-Jun Zhang^1,3

1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China;
2 Graduate School of the Chinese Academy of Sciences, Beijing 100039, People's Republic of China;
3 Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China

Received:2019-09-23 Revised:2019-10-24 Online:2019-12-24 Published:2019-12-11
Contact: Ying-Jun Zhang
Supported by:
The authors appreciate the members of the analytical group at the State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, for measuring the spectroscopic data. This work was partially supported by Yunnan Key Laboratory of Natural Medicinal Chemistry (S2017-ZZ14).

摘要/Abstract

摘要： Phytochemical studies on MeOH extract of stems of Euphorbia griffithii led to the isolation of one new hydrolyzable tannin dimer, corilagiffithiin (1) and one new galloyl-glucoside (2), alongside six known ones (3-8). Their structures and absolute configurations were determined by in depth spectroscopic analyses and comparison of their 1D NMR and MS data with literature reported values. Configurations of sugar moieties were determined by acidic hydrolysis and subsequent GC analysis of their corresponding trimethylsilylated L-cysteine adduct. At a concentration of 50 μM, compounds 1-3 showed no anti-inflammatory activities.

关键词: Euphorbiaceae, Euphorbia griffithii, Phenolic glycosides, Hydrolyzable tannins

Abstract: Phytochemical studies on MeOH extract of stems of Euphorbia griffithii led to the isolation of one new hydrolyzable tannin dimer, corilagiffithiin (1) and one new galloyl-glucoside (2), alongside six known ones (3-8). Their structures and absolute configurations were determined by in depth spectroscopic analyses and comparison of their 1D NMR and MS data with literature reported values. Configurations of sugar moieties were determined by acidic hydrolysis and subsequent GC analysis of their corresponding trimethylsilylated L-cysteine adduct. At a concentration of 50 μM, compounds 1-3 showed no anti-inflammatory activities.

Key words: Euphorbiaceae, Euphorbia griffithii, Phenolic glycosides, Hydrolyzable tannins

Joseph Sakah Kaunda, Ying-Jun Zhang. Two New Phenolic Constituents from the Stems of Euphorbia griffithii[J]. 应用天然产物, 2019, 9(6): 405-410.

Joseph Sakah Kaunda, Ying-Jun Zhang. Two New Phenolic Constituents from the Stems of Euphorbia griffithii[J]. Natural Products and Bioprospecting, 2019, 9(6): 405-410.

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Two New Phenolic Constituents from the Stems of Euphorbia griffithii

Two New Phenolic Constituents from the Stems of Euphorbia griffithii

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