Effectiveness of Echinochrome on HFD-Induced Hyperlipidemia in Rats

doi:10.1007/s13659-019-00221-4

应用天然产物 ›› 2019, Vol. 9 ›› Issue (5): 337-344.DOI: 10.1007/s13659-019-00221-4

• ORIGINAL ARTICLES • 上一篇下一篇

Effectiveness of Echinochrome on HFD-Induced Hyperlipidemia in Rats

Sohair R. Fahmy¹, Nashwah Ismail Zaki², Shaimaa Zakaria Eid¹, Ayman Saber Mohamed¹, Sarah S. Hassanein¹

1 Zoology Department, Faculty of Science, Cairo University, Giza 12613, Egypt;
2 Physiology Department, National Organization for Drug Control and Research, Cairo, Egypt

收稿日期:2019-08-21 修回日期:2019-10-06 出版日期:2019-10-24 发布日期:2019-10-30
通讯作者: Ayman Saber Mohamed, Sohair R. Fahmy, Nashwah Ismail Zaki, Shaimaa Zakaria Eid, Sarah S. Hassanein

Effectiveness of Echinochrome on HFD-Induced Hyperlipidemia in Rats

Sohair R. Fahmy¹, Nashwah Ismail Zaki², Shaimaa Zakaria Eid¹, Ayman Saber Mohamed¹, Sarah S. Hassanein¹

1 Zoology Department, Faculty of Science, Cairo University, Giza 12613, Egypt;
2 Physiology Department, National Organization for Drug Control and Research, Cairo, Egypt

Received:2019-08-21 Revised:2019-10-06 Online:2019-10-24 Published:2019-10-30
Contact: Ayman Saber Mohamed, Sohair R. Fahmy, Nashwah Ismail Zaki, Shaimaa Zakaria Eid, Sarah S. Hassanein

摘要/Abstract

摘要： Obesity has been identified with an expanded danger of a progression of illnesses that include different organ-frameworks of the body. In the present examination, we evaluated the hypolipidemic properties of Echinochrome (Ech) pigment in a highfat diet (HFD) induced hyperlipidemia in rats. After the hyperlipidemic model was set up, rats were haphazardly separated into five groups as follows:normal control group, HFD group, Atorvastatin (ATOR) group (80 mg/kg), Ech group (1 mg/kg) and combined group ATOR + Ech. The outcomes demonstrated that Ech improves lipid profile, liver functions, kidney functions and antioxidant markers of obese rats. The findings of the present investigation indicated that the Ech possesses hypolipidemic potential in obese rats.

关键词: High-fat diet, Atorvastatin, Echinochrome, Obesity, Oxidative stress

Abstract: Obesity has been identified with an expanded danger of a progression of illnesses that include different organ-frameworks of the body. In the present examination, we evaluated the hypolipidemic properties of Echinochrome (Ech) pigment in a highfat diet (HFD) induced hyperlipidemia in rats. After the hyperlipidemic model was set up, rats were haphazardly separated into five groups as follows:normal control group, HFD group, Atorvastatin (ATOR) group (80 mg/kg), Ech group (1 mg/kg) and combined group ATOR + Ech. The outcomes demonstrated that Ech improves lipid profile, liver functions, kidney functions and antioxidant markers of obese rats. The findings of the present investigation indicated that the Ech possesses hypolipidemic potential in obese rats.

Key words: High-fat diet, Atorvastatin, Echinochrome, Obesity, Oxidative stress

Sohair R. Fahmy, Nashwah Ismail Zaki, Shaimaa Zakaria Eid, Ayman Saber Mohamed, Sarah S. Hassanein. Effectiveness of Echinochrome on HFD-Induced Hyperlipidemia in Rats[J]. 应用天然产物, 2019, 9(5): 337-344.

Sohair R. Fahmy, Nashwah Ismail Zaki, Shaimaa Zakaria Eid, Ayman Saber Mohamed, Sarah S. Hassanein. Effectiveness of Echinochrome on HFD-Induced Hyperlipidemia in Rats[J]. Natural Products and Bioprospecting, 2019, 9(5): 337-344.

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Effectiveness of Echinochrome on HFD-Induced Hyperlipidemia in Rats

Effectiveness of Echinochrome on HFD-Induced Hyperlipidemia in Rats

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