Phenolic Constituents with Antioxidative, Tyrosinase Inhibitory and Anti-aging Activities from Dendrobium loddigesii Rolfe

doi:10.1007/s13659-019-00219-y

应用天然产物 ›› 2019, Vol. 9 ›› Issue (5): 329-336.DOI: 10.1007/s13659-019-00219-y

Phenolic Constituents with Antioxidative, Tyrosinase Inhibitory and Anti-aging Activities from Dendrobium loddigesii Rolfe

Rui-Jing Ma^1,2, Liu Yang^1,3, Xue Bai¹, Jin-Yu Li¹, Ming-Yan Yuan^1,3, Ya-Qin Wang³, Yong Xie³, Jiang-Miao Hu^1,3, Jun Zhou¹

1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
2 College of Pharmacy, Guilin Medical University, Guilin 541004, People's Republic of China;
3 R&D Center of Dr. Plant, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China

收稿日期:2019-06-10 修回日期:2019-09-15 出版日期:2019-10-24 发布日期:2019-10-30
通讯作者: Jiang-Miao Hu
基金资助:
This project was supported financially by the Yunnan Provincial Science and Technology Department (Nos. 2017ZF003-04, 2015HB093 and 2019HA001). Authors are grateful to the staff of the analytical group of the State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, for measurements of all spectra.

Phenolic Constituents with Antioxidative, Tyrosinase Inhibitory and Anti-aging Activities from Dendrobium loddigesii Rolfe

Rui-Jing Ma^1,2, Liu Yang^1,3, Xue Bai¹, Jin-Yu Li¹, Ming-Yan Yuan^1,3, Ya-Qin Wang³, Yong Xie³, Jiang-Miao Hu^1,3, Jun Zhou¹

1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
2 College of Pharmacy, Guilin Medical University, Guilin 541004, People's Republic of China;
3 R&D Center of Dr. Plant, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China

Received:2019-06-10 Revised:2019-09-15 Online:2019-10-24 Published:2019-10-30
Contact: Jiang-Miao Hu
Supported by:
This project was supported financially by the Yunnan Provincial Science and Technology Department (Nos. 2017ZF003-04, 2015HB093 and 2019HA001). Authors are grateful to the staff of the analytical group of the State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, for measurements of all spectra.

摘要/Abstract

摘要： Aqueous ethanol extracts of powdered stems of Dendrobium loddigesii afforded three new phenolics including threo-7-O-ethyl-9-O-(4-hydroxyphenyl)propionyl-guaiacylglycerol (1), (R)-4,5,4'-trihydroxy-3,3',α-trimethoxybibenzyl (2) and (S)-5,5',7-trihydroxy-3',4'-dimethoxyflavanone (3), together with eleven known analogues. Their structures were determined by extensive spectroscopic analysis. To identify natural antioxidants, whitening, and anti-aging agents, the abilities of these phenolics were assessed to scavenge the 1,2-diphenyl-2-picrylhydrazyl (DPPH) radical, their abilities to inhibit tyrosinase production, and their abilities to stimulate collagen production by human dermal fibroblasts-adult (HDFa) assay. It was found that compounds 1, 4-8, 13 and 14 exhibited significant DPPH radical scavenging activities, compound 10 exhibited tyrosinase inhibitory activity (IC₅₀ 37.904 μg/mL), and compound 9 showed significant collagen production with an EC₅₀ value of 3.182 μg/mL. These results suggest that phenolic constituents from D. loddigesii may be candidate antioxidants, skin-whitening and/or anti-aging agents.

关键词: Dendrobium loddigesii, Phenolic constituents, Antioxidative, Tyrosinase inhibitory, Anti-aging

Abstract: Aqueous ethanol extracts of powdered stems of Dendrobium loddigesii afforded three new phenolics including threo-7-O-ethyl-9-O-(4-hydroxyphenyl)propionyl-guaiacylglycerol (1), (R)-4,5,4'-trihydroxy-3,3',α-trimethoxybibenzyl (2) and (S)-5,5',7-trihydroxy-3',4'-dimethoxyflavanone (3), together with eleven known analogues. Their structures were determined by extensive spectroscopic analysis. To identify natural antioxidants, whitening, and anti-aging agents, the abilities of these phenolics were assessed to scavenge the 1,2-diphenyl-2-picrylhydrazyl (DPPH) radical, their abilities to inhibit tyrosinase production, and their abilities to stimulate collagen production by human dermal fibroblasts-adult (HDFa) assay. It was found that compounds 1, 4-8, 13 and 14 exhibited significant DPPH radical scavenging activities, compound 10 exhibited tyrosinase inhibitory activity (IC₅₀ 37.904 μg/mL), and compound 9 showed significant collagen production with an EC₅₀ value of 3.182 μg/mL. These results suggest that phenolic constituents from D. loddigesii may be candidate antioxidants, skin-whitening and/or anti-aging agents.

Key words: Dendrobium loddigesii, Phenolic constituents, Antioxidative, Tyrosinase inhibitory, Anti-aging

Rui-Jing Ma, Liu Yang, Xue Bai, Jin-Yu Li, Ming-Yan Yuan, Ya-Qin Wang, Yong Xie, Jiang-Miao Hu, Jun Zhou. Phenolic Constituents with Antioxidative, Tyrosinase Inhibitory and Anti-aging Activities from Dendrobium loddigesii Rolfe[J]. 应用天然产物, 2019, 9(5): 329-336.

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Phenolic Constituents with Antioxidative, Tyrosinase Inhibitory and Anti-aging Activities from Dendrobium loddigesii Rolfe

Phenolic Constituents with Antioxidative, Tyrosinase Inhibitory and Anti-aging Activities from Dendrobium loddigesii Rolfe

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