Sugar Derivatives of Morphine: A New Window for the Development of Potent Anesthetic Drugs

doi:10.1007/s13659-015-0060-8

应用天然产物 ›› 2015, Vol. 5 ›› Issue (3): 111-127.DOI: 10.1007/s13659-015-0060-8

• Review • 下一篇

Sugar Derivatives of Morphine: A New Window for the Development of Potent Anesthetic Drugs

Shyamal K. Jash¹, Dilip Gorai²

1. Department of Chemistry, Saldiha College(Affiliated to the University of Burdwan), Saldiha, Bankura 722 173, West Bengal, India;
2. Department of Chemistry, Kulti College(Affiliated to the University of Burdwan), Kulti, Burdwan 713 343, West Bengal, India

收稿日期:2015-03-05 修回日期:2015-04-20 出版日期:2015-06-24 发布日期:2018-02-11

Sugar Derivatives of Morphine: A New Window for the Development of Potent Anesthetic Drugs

Shyamal K. Jash¹, Dilip Gorai²

1. Department of Chemistry, Saldiha College(Affiliated to the University of Burdwan), Saldiha, Bankura 722 173, West Bengal, India;
2. Department of Chemistry, Kulti College(Affiliated to the University of Burdwan), Kulti, Burdwan 713 343, West Bengal, India

Received:2015-03-05 Revised:2015-04-20 Online:2015-06-24 Published:2018-02-11

摘要/Abstract

摘要： This review provides a short account of carbohydrate derivatives of an important natural drug, morphine, along with their comparative efficacies as anesthetic agent. Sugar derivatives are found to have more prospect as anesthetic drug than morphine itself owing to their enhanced bioavailability. Synthetic schemes of these sugar derivatives and information on related patents are also included in this manuscript.

关键词: Morphine, Morphine glycosides, Synthesis, Bioavailability, Anesthetic agents, Related patents

Abstract: This review provides a short account of carbohydrate derivatives of an important natural drug, morphine, along with their comparative efficacies as anesthetic agent. Sugar derivatives are found to have more prospect as anesthetic drug than morphine itself owing to their enhanced bioavailability. Synthetic schemes of these sugar derivatives and information on related patents are also included in this manuscript.

Key words: Morphine, Morphine glycosides, Synthesis, Bioavailability, Anesthetic agents, Related patents

Shyamal K. Jash, Dilip Gorai. Sugar Derivatives of Morphine: A New Window for the Development of Potent Anesthetic Drugs[J]. 应用天然产物, 2015, 5(3): 111-127.

Shyamal K. Jash, Dilip Gorai. Sugar Derivatives of Morphine: A New Window for the Development of Potent Anesthetic Drugs[J]. Natural Products and Bioprospecting, 2015, 5(3): 111-127.

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Sugar Derivatives of Morphine: A New Window for the Development of Potent Anesthetic Drugs

Sugar Derivatives of Morphine: A New Window for the Development of Potent Anesthetic Drugs

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