Hypercohones A-C, acylphloroglucinol derivatives with homo-adamantane cores from Hypericum cohaerens

doi:10.1007/s13659-013-0032-9

应用天然产物 ›› 2013, Vol. 3 ›› Issue (5): 233-237.DOI: 10.1007/s13659-013-0032-9

Hypercohones A-C, acylphloroglucinol derivatives with homo-adamantane cores from Hypericum cohaerens

Xia LIU^a,b, Xing-Wei YANG^a,b, Chao-Qun CHEN^a, Chun-Yan WU^a, Jing-Jing ZHANG^a,b, Jun-Zeng MA^a, Huan WANG^a, Qin-Shi ZHAO^a, Li-Xin YANG^a, Gang XU^a

a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
b University of Chinese Academy of Sciences, Beijing 100049, China

收稿日期:2013-04-05 修回日期:2013-04-16 出版日期:2013-10-24 发布日期:2018-02-11
通讯作者: Gang XU,E-mail:xugang008@mail.kib.ac.cn
基金资助:
The work was financially supported by the foundations from NSFC (20972167), the Young Academic Leader Raising Foundation of Yunnan Province (No. 2009CI073), and the foundation from CAS to Dr Gang Xu.

Hypercohones A-C, acylphloroglucinol derivatives with homo-adamantane cores from Hypericum cohaerens

Xia LIU^a,b, Xing-Wei YANG^a,b, Chao-Qun CHEN^a, Chun-Yan WU^a, Jing-Jing ZHANG^a,b, Jun-Zeng MA^a, Huan WANG^a, Qin-Shi ZHAO^a, Li-Xin YANG^a, Gang XU^a

a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
b University of Chinese Academy of Sciences, Beijing 100049, China

Received:2013-04-05 Revised:2013-04-16 Online:2013-10-24 Published:2018-02-11
Supported by:
The work was financially supported by the foundations from NSFC (20972167), the Young Academic Leader Raising Foundation of Yunnan Province (No. 2009CI073), and the foundation from CAS to Dr Gang Xu.

摘要/Abstract

摘要： Three new homo-adamantanyl type natural products were derived from polyprenylated polycyclic acylphloroglucinol. Hypercohones A-C (1-3), along with five other known hypercohones (4-8), were isolated from the aerial parts of Hypericum cohaerens. The structures of 1-3 were elucidated on the basis of comprehensive spectroscopic analysis. The inhibitory activities of these isolates against five human cancer cell lines in vitro were tested.

关键词: Hypericum cohaerens, adamantane, acylphloroglucinol, hypercohone

Abstract: Three new homo-adamantanyl type natural products were derived from polyprenylated polycyclic acylphloroglucinol. Hypercohones A-C (1-3), along with five other known hypercohones (4-8), were isolated from the aerial parts of Hypericum cohaerens. The structures of 1-3 were elucidated on the basis of comprehensive spectroscopic analysis. The inhibitory activities of these isolates against five human cancer cell lines in vitro were tested.

Key words: Hypericum cohaerens, adamantane, acylphloroglucinol, hypercohone

Xia LIU, Xing-Wei YANG, Chao-Qun CHEN, Chun-Yan WU, Jing-Jing ZHANG, Jun-Zeng MA, Huan WANG, Qin-Shi ZHAO, Li-Xin YANG, Gang XU. Hypercohones A-C, acylphloroglucinol derivatives with homo-adamantane cores from Hypericum cohaerens[J]. 应用天然产物, 2013, 3(5): 233-237.

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Hypercohones A-C, acylphloroglucinol derivatives with homo-adamantane cores from Hypericum cohaerens

Hypercohones A-C, acylphloroglucinol derivatives with homo-adamantane cores from Hypericum cohaerens

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