Flavonoid oligomers from Chinese dragon's blood, the red resins of Dracaena cochinchinensis

doi:10.1007/s13659-012-0020-5

应用天然产物 ›› 2012, Vol. 2 ›› Issue (3): 111-116.DOI: 10.1007/s13659-012-0020-5

• Regular Article • 上一篇下一篇

Flavonoid oligomers from Chinese dragon's blood, the red resins of Dracaena cochinchinensis

Qing-An ZHENG^a, Min XU^a, Chong-Ren YANG^a,b, Dong WANG^a, Hai-Zhou LI^a, Hong-Tao ZHU^a, Ying-Jun ZHANG^a

a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
b Weihe Biotech Laboratory, Yuxi 653100, China

收稿日期:2012-03-05 修回日期:2012-03-27 出版日期:2012-06-24 发布日期:2018-02-11
通讯作者: Min XU,E-mail:xumin@mail.kib.ac.cn;Ying-Jun ZHANG,E-mail:zhangyj@mail.kib.ac.cn
基金资助:
This work was supported by the 973 Program of Ministry of Science and Technology of China(2011CB915503), the Fourteenth Candidates of the Young Academic Leaders of Yunnan Province(Min XU, 2011CI044), and NSFC 31060054.

Flavonoid oligomers from Chinese dragon's blood, the red resins of Dracaena cochinchinensis

Qing-An ZHENG^a, Min XU^a, Chong-Ren YANG^a,b, Dong WANG^a, Hai-Zhou LI^a, Hong-Tao ZHU^a, Ying-Jun ZHANG^a

a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
b Weihe Biotech Laboratory, Yuxi 653100, China

Received:2012-03-05 Revised:2012-03-27 Online:2012-06-24 Published:2018-02-11
Supported by:
This work was supported by the 973 Program of Ministry of Science and Technology of China(2011CB915503), the Fourteenth Candidates of the Young Academic Leaders of Yunnan Province(Min XU, 2011CI044), and NSFC 31060054.

摘要/Abstract

摘要： A detailed chemical investigation of the red resins from Dracaena cochinchinensis(Chinese dragon's blood) yielded five new flavonoid oligomers, named cochinchinenins D-H(1-5), together with a known biflavonoid, cinnabarone(6), and a mixture of two known biflavonoids, socotrin-4'-ol(7) and homoisosocotrin-4'-ol(8). Of these new compounds, 1-3 were biflavonoids and 4 and 5 were triflavonoids. Their structures were determined on the basis of spectroscopic analysis. The isolated compounds were tested for cytotoxicity(Cdc25), antibacterial(PEPT) and antifungal(YNG) activities.

关键词: Dracaena cochinchinensis, flavonoid oligomers, cochinchinenins D-H

Abstract: A detailed chemical investigation of the red resins from Dracaena cochinchinensis(Chinese dragon's blood) yielded five new flavonoid oligomers, named cochinchinenins D-H(1-5), together with a known biflavonoid, cinnabarone(6), and a mixture of two known biflavonoids, socotrin-4'-ol(7) and homoisosocotrin-4'-ol(8). Of these new compounds, 1-3 were biflavonoids and 4 and 5 were triflavonoids. Their structures were determined on the basis of spectroscopic analysis. The isolated compounds were tested for cytotoxicity(Cdc25), antibacterial(PEPT) and antifungal(YNG) activities.

Key words: Dracaena cochinchinensis, flavonoid oligomers, cochinchinenins D-H

Qing-An ZHENG, Min XU, Chong-Ren YANG, Dong WANG, Hai-Zhou LI, Hong-Tao ZHU, Ying-Jun ZHANG. Flavonoid oligomers from Chinese dragon's blood, the red resins of Dracaena cochinchinensis[J]. 应用天然产物, 2012, 2(3): 111-116.

参考文献

[1] Gupta, D.; Bleakley, B.; Gupta, R. K. J. Ethnopharmacol. 2008, 115, 361-380.
[2] Zheng, Q. A.; Chen, J. T.; Zhang, Y. J.; Yang, C. R. Acta Bot. Yunnan. 2003, Suppl. XIV, 102-107.
[3] Cai, X. T.; Xu, Z. F. Acta Bot. Yunnan. 1979, 1, 1-9.
[4] Camarda, L.; Merlini, L.; Nasini, G. Heterocycles 1983, 20, 39-43.
[5] Himmelreich, U.; Masaoud, M.; Adam, G.; Ripperger, H. Phytochemistry 1995, 39, 949-951.
[6] Masaoud, M.; Schmidt, J.; Adam, G. Phytochemistry. 1995, 38, 795-796.
[7] Masaoud, M.; Himmelreich, U.; Ripperger, H.; Adam, G. Planta Med. 1995, 61, 341-344.
[8] Masaoud, M.; Ripperger, H.; Himmerlreich, U.; Adam, G. Phytochemistry 1995, 38, 751-753.
[9] Masaoud, M.; Ripperger, H.; Porzel, A.; Adam, G. Phytochemistry 1995, 38, 745-749.
[10] Vachalkova, A.; Novotny, L.; Nejedlikova, M.; Suchy, V. Neoplasma 1995, 42, 313-316.
[11] Gonzalez, A. G.; Leon, F.; Sanchez-Pinto, L.; Padron, J. I.; Bermejo, J. J. Nat. Prod. 2000, 63, 1297-1299.
[12] Vesela, D.; Marek, R.; Ubik, K.; Lunerova, K.; Sklenar, V.; Suchy, V. Phytochemistry 2002, 61, 967-970.
[13] Bahaffi, S. O. S.; Bahaffi, A. A.; Abdel-Mogib, M. J. Saudi Chem. Soc. 2004, 8, 313-315.
[14] Gonzalez, A. G.; Leon, F.; Hernandez, J. C.; Padron, J. I.; Sanchez-Pinto, L.; Bermejo Barrera, J. Biochem. Syst. Ecol. 2004, 32, 179-184.
[15] Luo, Y.; Wang, H.; Hao, Y. X.; Zeng, Y. B.; Shen, H. Y.; Dai, H. F.; Mei, W. L. Planta Med. 2011, 77, 2053-2056.
[16] Adam, G.; Masaoud, M.; Ripperger, H.; Himmelreich, U.; Schmidt, J. Proc. Plant Growth Regul. Soc. Am. 1995, 22, 142-146.
[17] Zheng, Q. A.; Yang, C. R. Chin. Chem. Lett. 2003, 14, 1261-1264.
[18] Zheng, Q. A.; Yang, C. R. J. Asian Nat. Prod. Res. 2003, 5, 291-296.
[19] Zheng, Q. A.; Zhang, Y. J.; Li, H. Z.; Yang, C. R. Steroids 2004, 69, 111-119.
[20] Zheng, Q. A.; Li, H. Z.; Zhang, Y. J.; Yang, C. R. Steroids 2006, 71, 160-164.
[21] Zheng, Q. A.; Zhang, Y. J.; Yang, C. R. J. Asian Nat. Prod. Res. 2006, 8, 571-577.
[22] Silva, B. M.; Santos, R. P.; Mendes, L. S.; Guedes de Pinho, P.; Valentao, P.; Andrade, P. B.; Pereira, J. A.; Carvalho, M. Food Res. Int. 2011, 44, 2182-2189.
[23] Xu, M.; Zhang, Y. J.; Li, X. C.; Jacob, M. R.; Yang, C. R. J. Nat. Prod. 2010, 73, 1524-1528.
[24] Kougan, G.; Miyamoto, T.; Tanaka, C.; Paululat, T.; Mirjolet, J.; Duchamp, O.; Sondengam, B.; Lacaille-Dubois, M. J. Nat. Prod. 2010, 73, 1266-1270.
[25] Hernandez, J. C.; Leon, F.; Estevez, F.; Quintana, J.; Bermejo, J. Chem. Biodivers. 2006, 3, 62-68.
[26] Hernandez, J. C.; Leon, F.; Quintana, J.; Estevez, F.; Bermejo, J. Bioorg. Med. Chem. 2004, 12, 4423-4429.
[27] Gonzalez, A. G.; Hernandez, J. C.; Leon, F.; Padron, J. I.; Estevez, F.; Quintana, J.; Bermejo, J. J. Nat. Prod. 2003, 66, 793-798.
[28] Machala, M.; Kubinova, R.; Horavova, P.; Suchy, V. Phytother. Res. 2001, 15, 114-118.
[29] Luo, Y.; Wang, H.; Xu, X.; Mei, W.; Dai, H. Molecules 2010, 15, 8904-8914.
[30] Zhu, Y. D.; Zhang, P.; Yu, H. P.; Li, J.; Wang, M. W.; Zhao, W. M. J. Nat. Prod. 2007, 70, 1570-1577.
[31] Zhou, Z. H.; Wang, J. L.; Yang, C. R. Chin. Tradit. Herb. Drugs 1999, 30, 801-804.
[32] Zhou, Z. H.; Wang, J. L.; Yang, C. R. Acta Pharm. Sin. 2001, 36, 200-204.
[33] Zhou, Z. H.; Wang, J. L.; Yang, C. R. Chin. Tradit. Herb. Drugs 2001, 32, 484-486.
[34] Wang, J. L.; Li, X. C.; Jiang, D. F.; Yang, C. Y. Acta Bot. Yunnan. 1995, 17, 336-340.
[35] Lu, W. J.; Wang, X. F.; Chen, J. Y.; Lu, Y.; Wu, N.; Kang, W. J.; Zheng, Q. T. Acta Pharm. Sin. 1998, 33, 755-758.
[36] Zheng, Q. A.; Zhang, Y. J.; Li, H. Z.; Yang, C. R. Helv. Chim. Acta. 2004, 87, 1267-1171.
[37] He, L.; Wang, Z. H.; Liu, X. H.; Fang, D. C.; Li, H. M. Chin. J. Chem. 2004, 22, 867-869.
[38] Yong, K. L.; Lv, J. C.; Zhang, T. B.; Xu, L. R.; Chen, X. Nat. Prod. Res. 2008, 22, 1624-1626.
[39] Jia, R. R.; Zeng, G. Z.; Tan, N. H.; Fan, J. T.; Huang, H. Q.; Ji, C. J.; Hao, X. J.; Zhao, Q. S.; Li, C. M. Acta Bot. Yunnan. 2008, 30, 617-620.
[40] Jiang, L. H.; Tan, N. H.; Yang, Y. B.; Wang, J. S.; Fu, X.; Lars, J.; Hartwig, M.; Thomas, H. Acta Bot. Yunnan. 2003, 25, 90-94.
[41] Jiang, L. H.; Tan, N. H.; Zeng, G. Z.; Hao, X. J.; Zhang, Y. J.; Qiu, M. H. Acta Bot. Yunnan. 2008, 30, 378-380.

Flavonoid oligomers from Chinese dragon's blood, the red resins of Dracaena cochinchinensis

Flavonoid oligomers from Chinese dragon's blood, the red resins of Dracaena cochinchinensis

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