neo-Clerodane diterpenoids from Salvia dugesii and their bioactive studies

doi:10.1007/s13659-011-0016-6

应用天然产物 ›› 2011, Vol. 1 ›› Issue (2): 81-86.DOI: 10.1007/s13659-011-0016-6

• Regular Article • 上一篇下一篇

neo-Clerodane diterpenoids from Salvia dugesii and their bioactive studies

Gang XU^a, Fang ZHAO^b, Xian-Wen YANG^c, Juan ZHOU^b, Li-Xin YANG^a, Xiao-Ling SHEN^b, Ying-Jie HU^b, Qin-Shi ZHAO^a

a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
b Tropical Medicine Institute, Guangzhou University of Chinese Medicine, Guangzhou 510405, China;
c Key Laboratory of Marine Bio-resources Sustainable Utilization, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China

收稿日期:2011-09-07 修回日期:2011-09-21 出版日期:2011-04-24 发布日期:2017-11-24
通讯作者: Gang XU,E-mail:xugang008@mail.kib.ac.cn;Xiao-Ling SHEN,E-mail:xlshen66@hotmail.com
基金资助:
This work was supported financially by the National Basic Research Program of China(2009CB522300), the National Natural Science Foundation of China(No. 20702054), Shanghai Landscaping Administration Bureau Program(G102404), the foundation from the Chinese Academy of Sciences(2010KIBA10), and the Young Academic and Technical Leader Raising Foundation of Yunnan Province(No. 2009CI073).

neo-Clerodane diterpenoids from Salvia dugesii and their bioactive studies

Gang XU^a, Fang ZHAO^b, Xian-Wen YANG^c, Juan ZHOU^b, Li-Xin YANG^a, Xiao-Ling SHEN^b, Ying-Jie HU^b, Qin-Shi ZHAO^a

a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
b Tropical Medicine Institute, Guangzhou University of Chinese Medicine, Guangzhou 510405, China;
c Key Laboratory of Marine Bio-resources Sustainable Utilization, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China

Received:2011-09-07 Revised:2011-09-21 Online:2011-04-24 Published:2017-11-24
Supported by:
This work was supported financially by the National Basic Research Program of China(2009CB522300), the National Natural Science Foundation of China(No. 20702054), Shanghai Landscaping Administration Bureau Program(G102404), the foundation from the Chinese Academy of Sciences(2010KIBA10), and the Young Academic and Technical Leader Raising Foundation of Yunnan Province(No. 2009CI073).

摘要/Abstract

摘要： Salvia dugesii is an invasive plant in Yunnan, China. To tentatively explore its utilization, a systematic phytochemical investigation was carried out on this plant, which led to the isolation of five new neo-clerodane diterpenoids, dugesins C-G(1-5), together with six known ones. Their structures were determined by comprehensive NMR and MS spectroscopic analysis. It was noteworthy that the eleven isolates, composed of five different carbocyclic systems derived from the neo-clerodane diterpenoid skeleton, were reported from the same plant for the first time. The anti-feedantial, cytotoxic, and antiviral activities of the isolates were evaluated. Dugesin F(4) was tested to be a non-toxic antiviral compound against influenza virus FM1.

关键词: Salvia dugesii, neo-clerodane diterpenoids, dugesins, antivirus

Abstract: Salvia dugesii is an invasive plant in Yunnan, China. To tentatively explore its utilization, a systematic phytochemical investigation was carried out on this plant, which led to the isolation of five new neo-clerodane diterpenoids, dugesins C-G(1-5), together with six known ones. Their structures were determined by comprehensive NMR and MS spectroscopic analysis. It was noteworthy that the eleven isolates, composed of five different carbocyclic systems derived from the neo-clerodane diterpenoid skeleton, were reported from the same plant for the first time. The anti-feedantial, cytotoxic, and antiviral activities of the isolates were evaluated. Dugesin F(4) was tested to be a non-toxic antiviral compound against influenza virus FM1.

Key words: Salvia dugesii, neo-clerodane diterpenoids, dugesins, antivirus

Gang XU, Fang ZHAO, Xian-Wen YANG, Juan ZHOU, Li-Xin YANG, Xiao-Ling SHEN, Ying-Jie HU, Qin-Shi ZHAO. neo-Clerodane diterpenoids from Salvia dugesii and their bioactive studies[J]. 应用天然产物, 2011, 1(2): 81-86.

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neo-Clerodane diterpenoids from Salvia dugesii and their bioactive studies

neo-Clerodane diterpenoids from Salvia dugesii and their bioactive studies

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