Gallic Acid Esters of Bergenin from Saxifraga melanocentra (Saxifragaceae) and Their Inhibition Against HCV NS3 Protease

Plant Diversity ›› 2007, Vol. 29 ›› Issue (04): 486-488.

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Gallic Acid Esters of Bergenin from Saxifraga melanocentra (Saxifragaceae) and Their Inhibition Against HCV NS3 Protease

ZUO Guo-Ying^{1 , 2} , LI Zheng-Quan¹ , Chen Li-Rong¹ , HE Hong-Ping³ , XU Xiao-Jie¹

1 College of Chemistry and Molecular Engineering , Yangshengtang Nature Medicine Laboratory , Peking University, Beijing 100871 , China ; 2 Kunming General Hospital , Kunming 650032 , China; 3 The State Key Laboratory
of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204 , China

Received:2006-10-11 Online:2007-08-25 Published:2007-08-25
Contact: XU Xiao-Jie

黑蕊虎耳草中岩白菜素没食子酸酯类及其对丙型肝炎丝氨酸蛋白酶的抑制作用

左国营^{1 , 2} , 李正全¹ , 陈丽蓉¹ , 何红平³ , 徐筱杰¹

1 北京大学化学与分子工程学院, 养生堂天然药物实验室, 北京 100871; 2 昆明总医院, 云南昆明 650032; 3 中国科学院昆明植物研究所西部植物化学与植物资源国家重点实验室, 云南昆明 650204

通讯作者: 徐筱杰

Abstract

Abstract: To study the chemical and bioactive characteristics of bergenin derivatives which were purified from Saxifraga melanocentra Franch ., a new gallic acid ester of bergenin , 11- O- (4 - O-methylgalloyl) bergenin (1) was isolated from the aerial parts of Saxifraga melanocentra Franch ., and its structure was established mainly on the basis of 1D and 2D NMR spectroscopic analysis . It showed weak inhibitory activity against HCV NS3 serine protease with IC50 of 0.32mg/ml .

Key words: HCV NS3 serine protease

摘要： 研究了黑蕊虎耳草( Saxifraga melanocentra) 中岩白菜素衍生物的化学和生物活性, 从其地上部分分离纯化得到一个新的岩白菜素没食子酸酯, 主要通过1 维和2 维核磁共振波谱鉴定结构为11-氧-(4-氧甲基没食子酰) 岩白菜素[11- O - (4- O-methylgalloyl) bergenin (1 ) ] , 该化合物对丙型肝炎丝氨酸蛋白酶(HCVNS3 serine protease ) 具有抑制活性, 其IC50 为0 . 32 mg􊄯mL。

关键词: 抗丙型肝炎, 黑蕊虎耳草, 11-氧- (4-氧甲基没食子酰) 岩白菜素, IC50FONT

CLC Number:

Q 946

ZUO Guo-Ying^, , LI Zheng-Quan , Chen Li-Rong , HE Hong-Ping , XU Xiao-Jie. Gallic Acid Esters of Bergenin from Saxifraga melanocentra (Saxifragaceae) and Their Inhibition Against HCV NS3 Protease
[J]. Plant Diversity, 2007, 29(04): 486-488.

左国营1 , 2 , 李正全1 , 陈丽蓉1 , 何红平3 , 徐筱杰1 . 黑蕊虎耳草中岩白菜素没食子酸酯类及其对丙型肝炎丝氨酸蛋白酶的抑制作用[J]. Plant Diversity, 2007, 29(04): 486-488.

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Gallic Acid Esters of Bergenin from Saxifraga melanocentra (Saxifragaceae) and Their Inhibition Against HCV NS3 Protease

黑蕊虎耳草中岩白菜素没食子酸酯类及其对丙型肝炎丝氨酸蛋白酶的抑制作用

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