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Natural Products and Bioprospecting

Natural Products and Bioprospecting >

2014 , Vol. 4 >Issue 5: 257 - 270

DOI: https://doi.org/10.1007/s13659-014-0038-y

Endophytes as Producers of Peptides: An Overview About the Recently Discovered Peptides from Endophytic Microbes

  • Muna Ali Abdalla ,
  • Josphat C. Matasyoh
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  • 1. Department of Food Science and Technology, Faculty of Agriculture, University of Khartoum, 13314 Shambat, Khartoum North, Sudan;
    2. Department of Chemistry, Egerton University, P. O. Box 536, Egerton, Kenya

Received date: 2014-07-11

  Revised date: 2014-08-24

  Online published: 2018-02-11

Supported by

We thank the German Academic Exchange Service(DAAD), for the PHD grants and the Alexander von Humboldt Foundation, Germany, for the Georg Forster Postdoctoral fellowships to the authors.

Fold

Abstract

An endophyte is a fungus or bacterium that lives within a plant in a symbiotic relationship. Extensive colonization of the plant tissue by endophytes creates a barrier effect, where they outcompete and prevent pathogenic organisms from taking hold. This happens by producing secondary metabolites that inhibit the growth of the competitors or pathogens. In this way they play a very important role in the plant defence mechanisms. The metabolites produced by these endophytes fall within a wide range of classes of compounds that include peptides which are the focus of this review. Peptides are increasingly being selected for drug development because they are specific for their targets and have a higher degree of interactions. There have been quite a number of endophytic peptides reported in the recent past indicating that endophytes can be used for the production of peptide based drugs. Molecular screening for NRPS, which shows peptide producing capability, has also shown that endophytes are potential producers of peptides. The presence of NRPS also offers the possibility of genetic modifications which may generate peptides with high pharmacological activities. This review, therefore, aims to show the current status of peptides isolated from endophytic bacteria and fungi in the recent decade. Endophytes as potential sources of peptides according to NRPS studies will also be discussed.

Key words： Peptides; Endophytes; NRPS; Bioactivities; Genetic engineering

Cite this article

Muna Ali Abdalla , Josphat C. Matasyoh . Endophytes as Producers of Peptides: An Overview About the Recently Discovered Peptides from Endophytic Microbes[J]. Natural Products and Bioprospecting, 2014 , 4(5) : 257 -270 . DOI: 10.1007/s13659-014-0038-y

References

1. S.H. Faeth, Oikos 98, 25-36 (2002)
2. S.H. Faeth, Am. Nat. 173, 554-565 (2009)
3. S. Chandra, App. Microbiol. Biotehnol. 95, 47-59 (2012)
4. F. Waller, B. Achatz, H. Baltruschat, J. Fodor, K. Becker, M. Fischer, T. Heier, R. Hückelhoven, C. Neumann, D. von Wettstein, P. Franken, K.H. Kogel, Proc. Natl. Acad. Sci. USA 102, 13386-13391 (2005)
5. M. Saunders, A.E. Glenn, L.M. Kohn, Evol. Appl. 3, 525-537 (2010)
6. J.K. Stone, C.W. Bacon, J.F. White Jr, An overview of endophytic microbes:endophytism Defined, in Microbial Endophytes, ed. by C.W. Bacon, J.F. White Jr (Marcel Dekker, Inc, New York, 2000), pp. 3-29
7. A.L. Zhang, L.Y. He, J.M. Gao, X. Xu, S.Q. Li, M.S. Bai, J.C. Qin, Lipids 44, 745-751 (2009)
8. T.S. Suryanarayanan, Fungal Ecol. 6, 561-568 (2013)
9. R.J. Rodriguez, J.F. White Jr, A.E. Arnold, R.S. Redman, New Phytol. 182, 314-330 (2009)
10. M. Sherwood, G. Carroll, Mycologia 66, 499-506 (1974)
11. J.K. Stone, J.D. Polishook, J.F.Jr. White, in Endophytic Fungi, ed. by M.S. Foster, G.F. Bills, G. Mueller (Elsevier Inc, Amsterdam, 2004), pp. 241-270
12. K. Clay, C. Schardl, Am. Nat. 160(Suppl), S99-S127 (2002)
13. M. Knop, S. Pacyna, N. Voloshchuk, S. Kant, C. Müllenborn, U. Steiner, M. Kirchmair, H.W. Scherer, M. Schulz, J. Chem. Ecol. 33, 225-237 (2007)
14. G. Strobel, B. Daisy, U. Castillo, J. Harper, J. Nat. Prod. 67, 257-268 (2004)
15. R.S. Redman, K.B. Sheehan, R.G. Stout, R.J. Rodriguez, J.M. Henson, Science 298, 1581 (2002)
16. J.M. Costa, J.E. Loper, Mol. Plant-Microbe Interact. 7, 440-448 (1994)
17. S. Lee, M. Flores-Encarnación, M. Contreras-Zentella, L. Garcia-Flores, J.E. Escamilla, C. Kennedy, J. Bacteriol. 186, 5384-5391 (2004)
18. A. Morales, M. Alvear, E. Valenzuela, C.E. Castillo, F. Borie, J. Soil Sci. Plant Nutr. 11, 89-103 (2011)
19. B. Rodelas, V. Salmerón, M.V. Martinez-Toledo, J. GonzalezLópez, Plant Soil 153, 97-101 (1993)
20. WHO, General Guidelines for Methodologies on Research and Evaluation of Traditional Medicine (WHO, Geneva, 2000)
21. M.A. Abdalla, H. Laatsch, Afr. J. Tradit. Complem. Altern. Med. 9, 56-58 (2012)
22. WHO, Guidelines for the assessment of herbal medicines, Thirty-fourth Report, Technical Report Series, No. 863, Annex 11, Geneva 1996
23. U. Castillo, S. Myers, L. Browne, G. Strobel, W.M. Hess, J. Hanks, D. Reay, Scanning 27, 305-311 (2005)
24. H. Kunoh, J. Gen. Plant Pathol. 68, 249-252 (2002)
25. C.R. Bell, G.A. Dickie, W.L.G. Harvey, J.W.Y.F. Chan, Can. J. Microbiol. 41, 46-53 (1995)
26. J.M. Gardner, A.W. Feldman, R.M. Zablotowicz, App. Environ. Microbiol. 43, 1335-1342 (1982)
27. P.F. Scholander, E.D. Bradstreet, E.A. Hemmingsen, H.T. Hammel, Science 148, 339-346 (1965)
28. J. Hallmann, G. Berg, B. Schulz, Soil Biol. 9, 299-319 (2006)
29. J. Jumpathong, M.A. Abdalla, S. Lumyong, H. Laatsch, Nat. Prod. Commun. 5, 567-570 (2010)
30. S.R. Ghimire, N.D. Charlton, J.D. Bell, Y.L. Krishnamurthy, K.D. Craven, Fungal Divers. 47, 19-27 (2011)
31. M.A. Abdalla, Ph.d Thesis, Georg-August University of Gottingen, 2010
32. M.R. Pimentel, G. Molina, A.P. Dionísio, M.R.M. Junior, G.M. Pastore, Biotechnol. Res. Int. Article ID 576286 (2011)
33. G.A. Strobel, Microbes Infect. 5, 535-544 (2003)
34. C. Bomke, B. Tudzynski, Phytochem. 70, 1876-1893 (2009)
35. G.A. Strobel, R. Torczynski, A. Bollon, Plant Sci. 128, 97-108 (1997)
36. A. Cassone, R.E. Mason, D. Kerridge, Med. Mycol. 19, 97-110 (1981)
37. B.D. Alexander, M.D. Johnson, C.D. Pfeiffer, C. Jiménez-Ortigosa, J. Catania, R. Booker, M. Castanheira, S.A. Messer, D.S. Perlin, M.A. Pfaller, Clin. Infect. Dis. 56, 1724-1732 (2013)
38. D.W. Denning, J. Antimicrob. Chemother. 49, 889-891 (2002)
39. S.C. Chen, M.A. Slavin, T.C. Sorrell, Drugs 71, 11-41 (2011)
40. W.K. Mousa, M.N. Raizada, Front. Microbiol. 4, 1-18 (2013)
41. G.A. Strobel, R.V. Miller, C. Martinez-Miller, M.M. Condron, D.B. Teplow, W.M. Hess, Microbiology 145, 1919-1926 (1999)
42. N.K. Dubey, Natural Products in Plant Pest Management (CAB International, Preston, UK, 2011)
43. A. Segre, R.C. Bachmann, A. Ballio, F. Bossa, I. Grgurina, N.S. Iacobellis, G. Marino, P. Pucci, M. Simmaco, J.Y. Takemoto, FEBS Lett. 255, 27-31 (1989)
44. A. Ballio, F. Bossa, D.D. Giorgio, P. Ferranti, M. Paci, P. Pucci, A. Scaloni, A. Segre, G.A. Strobel, FEBS Lett. 355, 96-100 (1994)
45. L. Harrison, D.B. Teplow, M. Rinaldi, G. Strobel, Microbiology 137, 2857-2865 (1991)
46. C.M. Miller, R.V. Miller, D. Garton-Kenny, B. Redgrave, J. Sears, M.M. Condron, D.B. Teplow, G.A. Strobel, J. App. Microbiol. 84, 937-944 (1998)
47. J.H. Pan, E.B.G. Jones, Z.G. She, J.Y. Pang, Y.C. Lin, Bot. Mar. 51, 179-190 (2008)
48. W.Q. Yin, J.M. Zou, Z.G. She, L.L.P. Vrijmoed, E.B.G. Jones, Y.C. Lin, Chin. Chem. Lett. 16, 219-222 (2005)
49. R. Bara, A.H. Aly, V. Wray, W.H. Lin, P. Proksch, A. Debbab, Tetrahedron Lett. 54, 1686-1689 (2013)
50. A. Koulman, T.V. Lee, K. Fraser, L. Johnson, V. Arcus, J.S. Lott, S. Rasmussen, G. Lane, Phytochemistry 75, 128-139 (2012)
51. T.V. Lee, L.J. Johnson, R.D. Johnson, A. Koulman, G.A. Lane, J.S. Lott, V.L. Arcus, J. Biol. Chem. 285, 2415-2427 (2010)
52. L. Johnson, A. Koulman, M. Christensen, R. Johnson, G. Bryan, S. Rasmussen, Role of siderophores in grass-endophyte symbioses. Paper presented at the 8th International Mycological Congress. Australia, Cairns, 20-25 August 2006
53. R. Johnson, C. Voisey, L. Johnson, J. Pratt, D. Fleetwood, A. Khan, G. Bryan, Fungal Genet. Biol. 44, 1180-1190 (2007)
54. F. Rosconi, D. Davyt, V. Martínez, M. Martínez, J.A. AbinCarriquiry, H. Zane, A. Butler, E.M. de Souza, E. Fabiano, Environ. Microbiol. 15, 916-927 (2013)
55. R. Saha, N. Saha, R.S. Donofrio, L.L. Bestervelt, J. Basic Microbiol. 53, 303-317 (2013)
56. T. Baramov, K. Keijzer, E. Irran, E. Mosker, M.-H. Baik, R. Süssmuth, Chem. Eur. J. 19, 10536-10542 (2013)
57. J.H. Crosa, A.R. Mey, S.M. Payne, Iron Transport in Bacteria (American Society for Microbiology (ASM) Press, Washington DC, 2004), p. 17
58. K. Hotta, C.H. Kim, D.T. Fox, A.T. Koppisch, Microbiology 156, 1918-1925 (2010)
59. T. Gaonkar, P.K. Nayak, S. Garg, S. Bhosle, Sci. World J. Article ID 857249, 8 (2012)
60. M. Miethke, M.A. Marahiel, Microbiol. Mol. Biol. Rev. 71, 413-451 (2007)
61. S.M. Barry, G.L. Challis, Curr. Opin. Chem. Biol. 13, 205-215 (2009)
62. M.A. Abdalla, E. Helmke, H. Laatsch, Nat. Prod. Commun. 5, 1917-1920 (2010)
63. J.B. McAlpine, B.O. Bachmann, M. Piraee, S. Tremblay, A.M. Alarco, E. Zazopoulos, C.M. Farnet, J. Nat. Prod. 68, 449-493 (2005)
64. Y.T. Chen, Q. Yuan, L.T. Shan, M.A. Lin, D.Q. Cheng, C.Y. Li, Oncol. Lett. 5, 1787-1792 (2013)
65. H.J. Li, Y.C. Lin, J.H. Yao, L.L. Vrijmoed, G.E. Jones, J. Asian, Nat. Prod. Res. 6, 185-191 (2004)
66. H.J. Li, W.J. Lan, J.H. Yao, Y.C. Lin, Chin. J. Instrum. Anal. 24, 46-49 (2005)
67. Y. Shiono, M. Tsuchinari, K. Shimanuki, T. Miyajima, T. Murayama, T. Koseki, H. Laatsch, T. Funakoshi, K. Takanami, K. Suzuki, J. Antibiot. 60, 309-316 (2007)
68. H. Huang, Z. She, Y. Lin, L.L. Vrijmoed, W. Lin, J. Nat. Prod. 70, 1696-1699 (2007)
69. W. Ebrahim, J. Kjer, M. El Amrani, V. Wray, W. Lin, R. Ebel, D. Lai, P. Proksch, Mar. Drugs 10, 1081-1091 (2012)
70. G. Schmeda-Hirschmann, E. Hormazabal, J.A. Rodriguez, C. Theoduloz, Zeitschrift für Naturforschung C. 63, 383-388 (2008)
71. M.A. Abdalla, P.P. Yadav, B. Dittrich, A. Schüffler, H. Laatsch, Org. Lett. 13, 2156-2159 (2011)
72. M.A. Abdalla, H. Yu Win, M.T. Islam, A. von Tiedemann, A. Schüffler, H. Laatsch, J. Antibiot. 64, 655-659 (2011)
73. A. Christina, V. Christapher, S.J. Bhore, Pharmacog. Rev. 7, 11-16 (2013)
74. M.V. Tejesvi, D.R. Segura, K.M. Schnorr, D. Sandvang, S. Mattila, P.B. Olsen, S. Neve, T. Kruse, H.H. Kristensen, A.M. Pirttila, Fungal Divers. 60, 153-159 (2013)
75. Y. Kajimura, M. Kaneda, J. Antibiot. 49, 129-135 (1996)
76. D. Konz, A. Klens, K. Schorgendorfer, M.A. Marahiel, Chem. Biol. 4, 927-937 (1997)
77. H.B. Cui, W.L. Mei, C.D. Miao, H.P. Lin, K. Hong, H.F. Dai, Chin. J. Antibiot. 33, 407-410 (2008)
78. Y. Seto, K. Takahashi, H. Matsuura, Y. Kogami, H. Yada, T. Yoshihara, K. Nabeta, Biosci. Biotechnol. Biochem. 71, 1470-1475 (2007)
79. P. Chomcheon, S. Wiyakrutta, T. Aree, N. Sriubolmas, N. Ngamrojanavanich, C. Mahidol, S. Ruchirawat, P. Kittakoop, Chem. Eur. J. 16, 11178-11185 (2010)
80. H. Brückner, G.H. Paracelsin, Experientia 39, 528-530 (1983)
81. L. Maddau, A. Cabras, A. Franceschini, B.T. Linaldeddu, S. Crobu, T. Roggio, D. Pagnozzi, Microbiology 155, 3371-3381 (2009)
82. J.F.S. Daniel, E.R. Filho, Nat. Prod. Rep. 24, 1128-1141 (2007)
83. P.K. Mukherjee, A. Wiest, N. Ruiz, A. Keightley, M.E. MoranDiez, K. McCluskey, Y.F. Pouchus, C.M. Kenerley, J. Biol. Chem. 286, 4544-4554 (2011)
84. Y. Ren, G.A. Strobel, J.C. Graff, M. Jutila, S.G. Park, S. Gosh, D. Teplow, M. Condron, E. Pang, W.M. Hess, E. Moore, Microbiology 154, 1973-1979 (2008)
85. J.F. Borel, Z.L. Kis, Transplant. Proc. 23, 1867-1874 (1991)
86. A. Schüßler, C. Walker, Evolution of the ‘plant-symbiotic’ fungal phylum, Glomeromycota, in The Mycota XIV-Evolution of Fungi and Fungal-Like Organisms, ed. by S. Poggeler, J. Wostemeyer (Springer, Berlin, 2011), pp. 163-185
87. A.H. Zhang, X.Q. Wang, W.B. Han, Y. Sun, Y. Guo, Q. Wu, H.M. Ge, Y.C. Song, S.W. Ng, Q. Xu, R.X. Tan, Chem. Asian J. 8, 3101-3107 (2013)
88. G. Strobel, B. Daisy, Microbiol. Mol. Biol. Rev. 67, 491-502 (2003)
89. B. Guo, J.R. Dai, S. Ng, Y. Huang, C. Leong, W. Ong, B.K. Carté, J. Nat. Prod. 63, 602-604 (2000)
90. G. Strobel, E. Ford, J. Worapong, J.K. Harper, A.M. Arif, D.M. Grant, P.C. Fung, R. Wah Ming Chau, Phytochemistry 60, 179-183 (2002)
91. Y.L. Zhang, H.M. Ge, W. Zhao, H. Dong, Q. Xu, S.H. Li, J. Li, J. Zhang, Y.C. Song, R.X. Tan, Angew. Chem. 120, 5907-5910 (2008)
92. Y.L. Zhang, J. Zhang, N. Jiang, Y.H. Lu, L. Wang, S.H. Xu, W. Wang, G.F. Zhang, Q. Xu, H.M. Ge, J. Ma, Y.C. Song, R.X. Tan, J. Am. Chem. Soc. 133, 5931-5940 (2011)
93. A. Rüegger, M. Kuhn, H. Lichti, H.R. Loosli, R. Huguenin, C. Quiquerez, A. von Wartburg, Helv. Chim. Acta 59, 1075-1092 (1976)
94. U. Castillo, J.K. Harper, G.A. Strobel, J. Sears, K. Alesi, E. Ford, J. Lin, M. Hunter, M. Maranta, H. Ge, D. Yaver, J.B. Jensen, H. Porter, R. Robison, D. Millar, W.M. Hess, M. Condron, D. Teplow, FEMS Microbiol. Lett. 224, 183-190 (2003)
95. K. Watanabe, K. Hotta, A.P. Praseuth, K. Koketsu, A. Migita, C.N. Boddy, C.C. Wang, H. Oguri, H. Oikawa, Nat. Chem. Biol. 2, 423-428 (2006)
96. K. Watanabe, H. Oguri, H. Oikawa, Curr. Opin. Chem. Biol. 13, 189-196 (2009)
97. D. Ezra, U.F. Castillo, G.A. Strobel, W.M. Hess, H. Porter, J.B. Jensen, M.A. Condron, D.B. Teplow, J. Sears, M. Maranta, M. Hunter, B. Weber, D. Yaver, Microbiology 150, 785-793 (2004)
98. Dictionary of Natural Products on CD-ROM, London, Chapman & Hall, Chemical Database, 2003
99. U.F. Castillo, G.A. Strobel, K. Mullenberg, M.M. Condron, D.B. Teplow, V. Folgiano, M. Gallo, R. Ferracane, L. Mannina, S. Viel, M. Codde, R. Robison, H. Porter, J. Jensen, FEMS Microbiol. Lett. 255, 296-300 (2006)
100. U.F. Castillo, G.A. Strobel, E.J. Ford, W.M. Hess, H. Porter, J.B. Jensen, H. Albert, R. Robison, M.A. Condron, D.B. Teplow, D. Stevens, D. Yaver, Microbiology 148, 2675-2685 (2002)
101. H. Jenke-Kodama, E. Dittmann, Nat. Prod. Rep. 26, 874-883 (2009)
102. K.E. Bushley, B.G. Turgeon, BMC Evol. Biol. 10, 26 (2010)
103. R. Süssmuth, J. Müller, H. von Dohren, I. Molnar, Nat. Prod. Rep. 28, 99-124 (2011)
104. M. Strieker, A. Tanović, M.A. Marahiel, Curr. Opin. Struct. Biol. 20, 234-240 (2010)
105. D. Konz, S. Doekel, M.A. Marahiel, J. Bacteriol. 181, 133-140 (1999)
106. N.Z. Li, T. Xia, Y.L. Xu, R.R. Qiu, H. Xiang, D. He, Y.Y. Peng, J. Bacteriol. 194, 2117-2118 (2012)
107. H. Harzer, R.D. Johnson, S. Rasmussen, C.R. Voisey, L.J. Johnson, Characterization of a novel endophyte NRPS gene and its role in endophyte-grass symbioses. Paper presented at the Endophyte Symposium, New Zealand Grassland Association, 2007
108. J. Li, G.Z. Zhao, H.H. Chen, H.B. Wang, S. Qin, W.Y. Zhu, L.H. Xu, C.L. Jiang, W.J. Li, Lett. App. Microbiol. 47, 574-580 (2008)
109. W. Zhu, J. Li, G. Zhao, H. Huang, S. Qin, L. Zhao, L. Xu, Weishengwuxue Tongbao 37, 211-216 (2010)
110. J.E. Janso, G.T. Carter, App. Environ. Microbiol. 76, 4377-4386 (2010)
111. Z.J. Guo, Z.X. Feng, H.D. Wu, Y. He, R.Y. Ye, Y.W. Chu, Y.Q. Tian, Weishengwuxue Zazhi 31, 23-28 (2011)
112. Z.X. Feng, M. Li, Y. Liu, W.H. Lin, Y.W. Chu, Y.Q. Tian, Weishengwuxue Tongbao 38, 539-546 (2011)
113. K. Zhao, P. Penttinen, T. Guan, J. Xiao, Q. Chen, J. Xu, K. Lindstrom, L. Zhang, X. Zhang, G.A. Strobel, Curr. Microbiol. 62, 182-190 (2011)
114. K.I. Miller, C. Qing, D.M.Y. Sze, B.A. Neilan, PLoS ONE 7, e35953 (2012)
115. H. Luo, X. Lin, L. Zhang, N. Liu, Y. Huang, Wei Sheng Wu Xue Bao 52, 389-395 (2012)
116. Y. Wang, Y. Ji, H. Wang, Y. Chen, Z. Wang, Nanjing Nongye Daxue Xue Bao 35, 52-56 (2012)
117. K.I. Miller, C. Qing, D.M. Sze, B.D. Roufogalis, B.A. Neilan, Microbiol. Ecol. 64, 431-449 (2012)
118. J. Li, G.Z. Zhao, H.Y. Huang, S. Qin, W.Y. Zhu, L.X. Zhao, L.H. Xu, S. Zhang, W.J. Li, G. Strobel, Antonie Van Leeuwenhoek 101, 515-527 (2012)
119. D. Schwarzer, M.A. Marahiel, Naturwissenschaften 88, 93-101 (2001)
120. H. von Dohren, U. Keller, J. Vater, R. Zocher, Chem. Rev. 97, 2675-2706 (1997)
121. A. Raja, J. LaBonte, J. Lebbos, P. Kirkpatrick, Nat. Rev. Drug Discov. 2, 943-944 (2003)
122. S.C. Feifel, T. Schmiederer, T. Hornbogen, H. Berg, R.D. Süssmuth, R. Zocher, ChemBioChem 8, 1767-1770 (2007)
123. A. Alvin, K.I. Miller, B.A. Neilan, Microbiol. Res. 169, 483-495 (2014)
124. D. Hoffmeister, N.P. Keller, Nat. Prod. Rep. 24, 393-416 (2007)
125. J. Müller, S.C. Feifel, T. Schmiederer, R. Zocher, R.D. Süssmuth, ChemBioChem 10, 323-328 (2009)
126. D. Matthes, L. Richter, J. Müller, A. Denisiuk, S.C. Feifel, Y. Xu, P. Espinosa-Artiles, R.D. Süssmuth, I. Molnar, Chem. Commun. 48, 5674-5676 (2012)
127. H.B. Bode, R. Müller, J. Ind. Microbiol. Biot. 33, 577-588 (2006)
128. M. Wei, S. Wang, G. Shang, Curr. Org. Chem. 14, 1433-1446 (2010)
129. M.S. Butler, Nat. Prod. Rep. 25, 475-516 (2008)
130. D.J. Craik, J.S. Mylne, N.L. Daly, Cell. Mol. Life Sci. 67, 9-16 (2010)
131. D.J. Craik, D.P. Fairlie, S. Liras, D. Price, Chem. Biol. Drug Des. 81, 136-147 (2013)
132. D.G.I. Kingston, J. Nat. Prod. 74, 496-511 (2011)
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