1. E.C. Raphael, Res. J. Pharmacol. 5(6), 90-94 (2011)
2. O. Jansen, M. Tits, L. Angenot, J. Nicolas, P. De Mol, J. Nikiema, M. Frédérich, Malar. J. 11, 1-9 (2012)
3. W.R. Sawadogo, A. Maciuk, J.T. Banzouzi, P. Champy, B. Figadere, I.P. Guissou, O.G. Nacoulma, Nat. Prod. Res. 26(6), 575-579 (2012)
4. S.Y. Kamble, S.R. Patil, P.S. Sawant, S. Sawant, S.G. Pawar, E.A. Singh, J. Indian, Tradit. Knowl. 9(3), 591-598 (2010)
5. I.A. Ekpo, R.B. Agbor, A.N. Osuagwu, B.E. Ekanem, E.C. Okpako, I.S. Urua, World J. Biol. Res. 5(2), 41-44 (2012)
6. Thomas, G. Medicinal Chemistry (Wiley, Southern Gate, Chichester, 2007), p 15. www.wileyeurope.com
7. World Health Organization (WHO) Facts sheet http://www.who.int/mediacentre/news/releases/2004/pr44/en/. Accessed on 03 Dec 2013
8. K. Busia, Phytother. Res. 19, 919-923 (2005)
9. World Health Organisation:Traditional medicine. Fact sheet No 134 (WHO, Geneva, 2003)
10. F.B. Magassouba, A. Diallo, M. Kouyate, F. Mara, O. Mara, O. Bangoura, A. Camara, S. Traore, A.K. Diallo, M. Zaoro, K. Lamah, S. Diallo, G. Camara, S. Traore, A. Keita, M.K. Camara, R. Barry, S. Keita, K. Oulare, M.S. Barry, M. Donzo, K. Camara, K. Tote, D. Vanden Berghe, J. Totte, L. Pieters, A.J. Vlietinck, A.M. Balde, J. Ethnopharmacol. 114, 44-53 (2007)
11. F.M.D. Ogbe, O.L. Eruogun, M. Uwagboe, Sci. Res. Essay. 4(3), 120-130 (2009)
12. N.R.A. Ngono, M.M.L. Koanga, T.A. Tchinda, N.H. Magnifouet, C.P.R. Motso, B.Z. Mballa, E.R.M. Ebelle, F. Ndifor, L. Biyiti, Z.P.H. Amvam, Afr. J. Plant. Sci. 5(1), 15-21 (2001)
13. F. Ntie-Kang, J.A. Mbah, L.M. Mbaze, L.L. Lifongo, M. Scharfe, J. Ngo Hanna, F. Cho-Ngwa, P.A. Onguéné, L.C.O. Owono, E. Megnassan, W. Sippl, S.M.N. Efange, BMC Complement. Altern. Med. 13, 88 (2013)
14. P.S. Njomnang, F. Benoit-Vical, J. Ethnopharmacol. 114, 130-140 (2007)
15. A. Ramazani, S. Zakeri, S. Sardari, N. Khodakarim, N. Djadidt, Malar. J. 9, 124-131 (2010)
16. O. Kayser, A.F. Kiderlen, H. Laatsch, S.L. Croft, Acta Trop. 77, 307-314 (2000)
17. M.A. Sonibare, Z.O. Gbile, Afr. J. Trad. CAM. 5(4), 340-345 (2008)
18. A. Adamu, E.M. Abdurahman, H. Ibrahim, M.S. Abubakar, M.G. Magaji, A.H. Yaro, Niger. J. Pharm. Sci. 6(2), 1-6 (2007)
19. O. Silva, A. Duarte, M. Pimentel, S. Viegas, H. Barroso, J. Machado, J. Ethnopharmacol. 57, 203-207 (1997)
20. M.S. Abubakar, A.M. Musa, A. Ahmed, I.M. Hussaini, J. Ethnopharmacol. 111, 625-629 (2007)
21. Y.J. Xu, R.I. Capistrano, L. Dhooghe, K. Foubert, F. Lemière, S. Maregesi, A. Baldé, S. Apers, L. Pieters, Planta Med. 77, 1139-1148 (2011)
22. M. Idu, J.O. Erhabor, H.M. Efijuemue, Trop. J. Pharm. Res. 9(2), 110-118 (2010)
23. R. Sanogo, Afr. J. Tradit. CAM. 8, 90-96 (2011)
24. Administrative Map of Nigeria-Nations Online Project. www. nationsonline.org
25. O.C. Library, in Country Profile:Nigeria 2008, pp. 1-23
26. B.A. Usman, L.L. Adefalu, Trop. Conserv. Biodivers. 11(3-4), 44-52 (2010)
27. E.O. Ogbadoyi, A.O. Abdulganiy, T.Z. Adama, J.I. Okogun, J. Ethnopharmacol. 112, 85-89 (2007)
28. D.A. Akinpelu, T.M. Onakoya, Afr. J. Biotechnol. 5(11), 1078-1081 (2006)
29. I.P. Dike, O.O. Obembe, F.E. Adebiyi, J. Ethnopharmacol. 144(3), 618-626 (2012)
30. S.E. Atawodi, D.A. Ameh, S. Ibrahim, J.N. Andrew, H.C. Nzelibe, E.O. Onyike, K.M. Anigo, E.A. Abu, D.B. James, G.C. Njoku, A.B. Sallau, J. Ethnopharmacol. 79, 279-282 (2002)
31. K.A. Abo, A.A. Fred-jaiyesimi, A.E.A. Jaiyesimi, J. Ethnopharmacol. 115, 67-71 (2008)
32. M.O. Soladoye, M.O. Adetayo, E.C. Chukwuma, A.N. Adetunji, Ann. Biol. Res. 1(4), 1-15 (2010)
33. O.A. Idowu, O.T. Soniran, O. Ajana, D.O. Aworinde, Afr. J. Pharm. Pharmacolol. 4(2), 55-60 (2010)
34. K.K. Ajibesin, B.A. Ekpo, D.N. Bala, E.E. Essien, S.A. Adesanya, J. Ethnopharmacol. 115, 387-408 (2008)
35. A. Adetutu, W.A. Morgan, O. Corcoran, J. Ethnopharmacol. 137(1), 50-56 (2011)
36. A.A. Gbolade, J. Ethnopharmacol. 121, 135-139 (2009)
37. A.A. Gbolade, J. Ethnopharmacol. 144(1), 1-10 (2012)
38. M. Idu, A.A. Umweni, T. Odaro, L. Ojelede, Ethnobot. Leafl. 13, 548-563 (2009)
39. F. Ntie-Kang, L.L. Lifongo, L.M. Mbaze, N. Ekwelle, L.C. Owono Owono, E. Megnassan, P.N. Judson, W. Sippl, S.M.N. Efange, BMC Complement. Altern. Med. 13, 147 (2013)
40. D. Zofou, F. Ntie-Kang, W. Sippl, S.M.N. Efange, Nat. Prod. Rep. 30, 1098-1120 (2013)
41. F. Ntie-Kang, P. Amoa Onguéné, M. Scharfe, L.M. Mbaze, L.C. Owono Owono, E. Megnassan, W. Sippl, S.M.N. Efange, RSC Adv. 4, 409-419 (2014)
42. F. Ntie-Kang, L.L. Lifongo, J.A. Mbah, L.C. Owono Owono, E. Megnassan, L.M. Mbaze, P.N. Judson, W. Sippl, S.M.N. Efange, In Silico Pharmacol 1, 12 (2013)
43. F. Ntie-Kang, J.A. Mbah, L.L. Lifongo, L.C. Owono Owono, E. Megnassan, L.M. Mbaze, P.N. Judson, W. Sippl, S.M.N. Efange, Org. Med. Chem. Lett. 3, 10 (2013)
44. F. Ntie-Kang, D. Zofou, S.B. Babiaka, R. Meudom, M. Scharfe, L.L. Lifongo, J.A. Mbah, L.M. Mbaze, W. Sippl, S.M.N. Efange, PLoS ONE 8(10), e78085 (2013)
45. J.O. Adebayo, A.U. Krettli, J. Ethnopharmacol. 133, 289-302 (2011)
46. H.A. Perez, M. De La Rosa, R. Apitz, Antimicrob. Agents Chemother. 38, 337-339 (1994)
47. A. Coppi, M. Cabinian, D. Mirelman, P. Sinnis, Antimicrob. Agents Chemother. 50, 1731-1737 (2006)
48. S.O. Okpo, O.O. Adeyemi, A.A. Onakade, West Afr. J. Pharmacol. Drug Res. 4 (2008). http://dx.doi.org/10.4314/wajpdr.v24i1.59046
49. C.C.A. Azikiwe, I.M. Siminialayi, N. Brambaifa, L.U. Amazu, J.C. Enye, M.C. Ezeani, Asian Pac. J. Trop. Dis. 4(Suppl 1), S446-S452 (2012)
50. P.J. Houghton, J.M. Agbedahunsi, A. Adegbulugbe, Phytochemistry 65, 2893-2896 (2004)
51. Y.H. Kim, E.J. Park, M.H. Park, U. Badarch, G.M. Woldemichael, J.A. Beutler, Biol. Pharm. Bull. 29(10), 2140-2142 (2006)
52. K. Bhadra, G.S. Kumar, Med. Res. Rev. 31(6), 821-862 (2011)
53. G. Bidla, V.P. Titanji, B. Joko, G.E. Ghazali, A. Bolad, K. Berzins, Ind. J. Pharmacol. 36, 245-246 (2004)
54. F. Jia, G. Zou, J. Fan, Z. Yuan, Arch. Virol. 155(8), 1325-1329 (2010)
55. K. Ezeamuzie, M.C. Ojinnaka, E.O. Uzogara, S.E. Orji, Afr. J. Med. Med. Sci. 23, 85-90 (1994)
56. J.E. Okokon, B.S. Antia, A.C. Igboasoiyi, E.E. Essien, H.O. Mbagwu, J. Ethnopharmacol. 111, 464-467 (2007)
57. E. Elisabetsky, L. Costa-Campos, eCAM 3(1), 39-48 (2006)
58. L.S. Kasim, V.A. Ferro, O.A. Odukoya, A. Drummond, G.E. Ukpo, V. Seidel, A.I. Gray, R.J. Waigh, Microbiol. Antimicrob. 3(1), 13-17 (2011)
59. S.M. Kupchan, R.J. Hemingway, A. Karim, D. Werner, J. Org. Chem. 34(12), 3908-3911 (1969)
60. J. Liobikas, D. Majiene, S. Trumbeckaite, L. Kursvietiene, R. Masteikova, D.M. Kopustinskiene, A. Savickas, J. Bernatoniene, J. Nat. Prod. 74(7), 1640-1644 (2011)
61. S.C. Gnoatto, A. Dassonville-Klimpt, S. Da Nascimento, P. Galéra, K. Boumediene, G. Gosmann, P. Sonnet, S. Moslemi, Eur. J. Med. Chem. 43(9), 1865-1877 (2008)
62. C.A. Elusiyan, N.C. Ani, C.O. Adewunmi, T.A. Olugbade, Afr. J. Tradit. CAM. 8(1), 27-33 (2011)
63. P. Picerno, G. Autore, S. Marzocco, M. Meloni, R. Sanogo, R.P. Aquino, J. Nat. Prod. 68(11), 1610-1614 (2005)
64. E.O. Iwalewa, L. Lege-Oguntoye, P.P. Rai, T.T. Iyaniwura, N.L. Etkin, West Afr. J. Pharmaceut. Drug Res. 9, 19-21 (1990)
65. C. Ancolio, N. Azas, V. Mahiou, E. Ollivier, C. Di Giorgio, A. Keita, P. Timon-David, G. Balansard, Phytother. Res. 16, 646-649 (2002)
66. H. Combier, M. Becchi, A. Cavé, Plantes Médicinales et Phytothérapie 11, 251-253 (1977)
67. O. Silva, E.T. Gomes, J. Nat. Prod. 66(3), 447-449 (2003)
68. M. Kuroda, A. Yokosuka, R. Kobayashi, M. Jitsuno, H. Kando, K. Nosaka, H. Ishii, T. Yamori, Y. Mimaki, Chem. Pharm. Bull. 55, 1240-1244 (2007)
69. I. Castillo-Juarez, V. Gonzalez, H. Jaime-Aguilar, G. Martínez, E. Linares, R. Bye, I. Romero, J. Ethnopharmacol. 122, 402-405 (2009)
70. J.O. Adebayo, E.A. Balogun, S.A. Oyeleke, Phcog. Res. 1, 143-147 (2009)
71. E. Goffin, E. Ziemons, P. De Mol, M. de Ceu de Madureira, A.P. Martins, A. Proenca da Cunha, G. Philippe, M. Tits, L. Angenot, M. Frederich, Planta Med. 68, 543-545 (2002)
72. M.E. Sanchez-Mendoza, A. Reyes-Ramírez, L.C. Antonio, L.M. Jiménez, J. Rodríguez-Silverio, J. Arrieta, Molecules 16, 665-674 (2011)
73. H.O. Egharevba, M.S. Abdullahi, S.K. Okwute, J.I. Okogun, Researcher 2(10), 35-40 (2010)
74. Y. Zhao, J. Yue, Z. Lin, J. Ding, H. Sun, Phytochemistry 44, 459-464 (1997)
75. A.A. Ahmadu, H.S. Hassan, M.U. Abubakar, I.N. Akpulu, Afr. J. Trad. CAM. 4(3), 257-260 (2007)
76. F.O. Ogungbamila, G.O. Onawunmi, O. Adeosun, Nat. Prod. Lett. 10, 201-203 (1997)
77. S. Jang, K.W. Kelley, R.W. Johnson, Proc. Natl. Acad. Sci. U.S.A. 105(21), 7534-7539 (2008)
78. T.C. Theoharides, J. Neuroinflammation 6, 29 (2009)
79. G. Zhao, G.W. Qin, J. Wang, W.J. Chu, L.H. Guo, Neurochem. Int. 56(1), 168-176 (2010)
80. M.C. Yu, J.H. Chen, C.Y. Lai, C.Y. Han, W.C. Ko, Eur. J. Pharmacol. 10627(1-3), 269-275 (2010)
81. S. Byun, K.W. Lee, S.K. Jung, E.J. Lee, M.K. Hwang, S.H. Lim, A.M. Bode, H.J. Lee, Z. Dong, Cancer Res. 70, 2415-2423 (2010)
82. M. López-Lazaro, Mini Rev. Med. Chem. 9(1), 31-59 (2009)
83. B.A. Adeniyi, M.F. Robert, H. Chai, H.H.S. Fong, Phytother. Res. 17, 282-284 (2003)
84. T.A. Tor-Anyiin, R. Shaato, H.O.A. Oluma, J. Herbs Spices Med. Plants 10, 61-74 (2003)
85. J.T. Banzouzi, R. Prado, H. Menan, A. Valentin, C. Roumestan, M. Mallie, Y. Pelissier, Y. Blache, J. Ethnopharmacol. 81, 399-401 (2002)
86. F.B.C. Okoye, P.O. Osadebe, C.S. Nworu, N.N. Okoye, E.O. Omeje, C.O. Esimone, Nat. Prod. Lett. 25(20), 1941-1949 (2011)
87. F.B.C. Okoye, P.O. Osadebe, Nat. Prod. Lett. 24(3), 266-273 (2010)
88. A. Falodun, T.C. Onwudiwe, Nnena, Bayero J. Pure Appl. Sci. 4(2), 1-4 (2011)
89. J.S. Ashidi, P.J. Houghton, P.J. Hylands, T. Efferth, J. Ethnopharmacol. 128, 501-512 (2010)
90. B.Z. Ahn, U. Degen, C. Lienjayetz, P. Pachaly, F. Zymalkowski, Arch. Pharm. 311, 569-578 (1978)
91. T. Matsumoto, T. Kobayashi, K. Ishida, Y. Hirasawa, H. Morita, T. Honda, K. Kamata, Biol. Pharm. Bull. 33(5), 844-848 (2010)
92. L.N. Ofodile, N. Uma, R.J. Grayer, O.T. Ogundipe, M.S.J. Simmonds, Phytother. Res. 26, 748-751 (2012)
93. R.R. Paterson, Phytochemistry 67(18), 1985-2001 (2006)
94. R.S. El Dine, A.M. El Halawany, C.M. Ma, M. Hattori, J. Nat. Prod. 71, 1022-1026 (2008)
95. J.C. Chukwujekwu, P. Smith, P.H. Coombes, D.A. Mulholland, J. van Staden, J. Ethnopharmacol. 102, 295-297 (2005)
96. D.E. Okwu, F.U. Nnamdi, Der. Chem. Sin. 2(2), 247-254 (2011)
97. N.M. Enwerem, J.I. Okogun, C.O. Wambebe, D.A. Okorie, P.A. Akah, Phytomedicine 8(2), 112-114 (2001)
98. S. Muhammad, N.A. Amusa, Res. J. Agric. Biol. Sci. 1, 254-260 (2005)
99. C. Limmatvapirat, S. Sirisopanaporn, P. Kittakoop, Planta Med. 70, 276-278 (2004)
100. E.O. Ajaiyeoba, J.S. Ashidi, L.C. Okpako, P.J. Houghton, C.W. Wright, Phytother. Res. 22, 254-255 (2008)
101. H. Morita, S. Oshimi, Y. Hirasawa, K. Koyama, T. Honda, W. Ekasari, G. Indrayanto, N.C. Zaini, Org. Lett. 9, 3691-3693 (2007)
102. S. Oshimi, Y. Tomizawa, Y. Hirasawa, T. Honda, W. Ekasari, A. Widyawaruyanti, M. Rudyanto, G. Indrayanto, N.C. Zaini, H. Morita, Bioorg. Med. Chem. Lett. 18, 3761-3763 (2008)
103. M.O. Agbo, D. Lai, F.B.C. Okoye, P.O. Osadebe, P. Proksch, Fitoterapia 86, 78-83 (2013)
104. E.O. Omeje, P.O. Osadebe, C.S. Nworu, J.N. Nwodo, W.O. Obonga, A. Kawamura, C.O. Esimone, P. Proksch, Pharmaceut. Biol. 49(12), 1271-1276 (2011)
105. G.C. Obute, Ethnomedicinal Plant Resources of South eastern Nigeria. Ethnobotanical Leaflets, 2005. http://www.siu.edu/*ebl/leaflets/obute.htm
106. S. Bertani, G. Bourdy, I. Landau, J.C. Robinson, P. Esterre, E. Deharo, J. Ethnopharmacol. 98, 45-54 (2005)
107. J.T. Banzouzi, R. Prado, H. Menan, A. Valentin, C. Roumestan, M. Mallie, Y. Pelissier, Y. Blache, Phytomedicine 11, 338-341 (2004)
108. D. Karou, M.H. Dicko, S. Sanon, J. Simpore, A.S. Traore, J. Ethnopharmacol. 89, 291-294 (2003)
109. V.Y.A. Barku, Y. Opoku-Boahen, E.Y. Dzotsi, Int. Res. J. Biochem. Bioinform. 2, 58-61 (2012)
110. K. Cimanga, T. De Bruyne, L. Peters, M. Claeys, A. Vlietinck, Tetrahedron Lett. 37, 1703-1706 (1996)
111. K. Cimanga, T. De Bruyne, L. Peters, A.J. Vlietinck, J. Nat. Prod. 60, 688-691 (1997)
112. S.Y. Ablordeppey, C.D. Hufford, R.F. Bourne, D. DwumaBadu, Planta Med. 56, 416 (1990)
113. A. Paulo, E.T. Gomes, J. Steele, D.C. Warhurst, P.J. Houghton, Planta Med. 66, 30-34 (2000)
114. C.E. Hadden, M.H.M. Sharaf, J.E. Guido, R.H. Robins, A.N. Tackie, C.H. Phoebe Jr, P.L. Schiff Jr, G.E. Martin, J. Nat. Prod. 62, 238-240 (1999)
115. A.B. Isah, Y.K. Ibrahim, E.O. Iwalewa, Phytother. Res. 17, 807-810 (2003)
116. J.M. Agbedahunsi, A.A. Elujoba, J.M. Makinde, A.M.J. Oduda, Pharm. Biol. 36, 8-12 (1998)
117. J.M. Agbedahunsi, A.A. Elujoba, Nig. J. Nat. Prod. Med. 2, 34-36 (1998)
118. J. Bickii, N. Nijifutie, J.A. Foyere, L.K. Basco, P. Ringwald, J. Ethnopharmacol. 69, 27-33 (2000)
119. S.G. Kamath, N. Chen, Y. Xiong, R. Wenham, S. Apte, M. Humphrey, J. Cragun, J.M. Lancaster, Int. J. Gynecol. Cancer 19(9), 1564-1569 (2009)
120. G.E.L. Brandt, M.D. Schmidt, T.E. Prisinzano, B.S.J. Blagg, J. Med. Chem. 51(20), 6495-6502 (2008)
121. I.A. Bello, G.I. Ndukwe, O.T. Audu, J.D. Habila, Org. Med. Chem. Lett. 1, 14 (2011)
122. T.O. Idowu, A.O. Ogundaini, A.O. Salau, E.M. Obuotor, M. Bezabih, B.M. Abegaz, Phytochemistry 71, 2092-2098 (2010)
123. S.O. Awe, J.M. Makinde, Ind. J. Pharmacol. 30, 51-53 (1998)
124. R.K. Cimanga, G.L. Tona, G.K. Mesia, O.K. Kambu, D.P. Bakana, P.D.T. Kalenda, A.O. Penge, J.J.T. Muyembe, J. Totté, L. Pieters, A.J. Vlietinck, Pharm. Biol. 44, 677-681 (2006)
125. O.O. Odebiyi, E.S. Sofowora, Planta Med. 36, 204-207 (1979)
126. E.O. Ajaiyeoba, U.I. Abalogu, H.C. Krebs, A.M.J. Oduola, J. Ethnopharmacol. 67, 321-325 (1999)
127. S. Bertani, E. Houël, D. Stien, L. Chevolot, V. Jullian, G. Garavito, G. Bourdy, E. Deharo, J. Ethnopharmacol. 108, 155-157 (2006)
128. I. Kitagawa, T. Mahmud, K.I. Yokota, S. Nakagawa, T. Mayumi, M. Kobayashi, H. Shibuya, Chem. Pharm. Bull. 41, 2009-2014 (1996)
129. N. Cachet, F. Hoakwie, S. Bertani, G. Bourdy, E. Deharo, D. Stien, E. Houel, H. Gornitzka, J. Fillaux, S. Chevalley, A. Valentin, V. Jullian, Antimicrob. Agents Chemother. 53(10), 4393-4398 (2009)
130. O.A. Odukoya, P.J. Houghton, A. Raman, Phytomedicine 6(4), 251-256 (1999)
131. V.P.K. Titanji, D. Zofou, M.N. Ngemenya, Afr. J. Trad. CAM. 5, 302-321 (2008)
132. V. Kuete, T. Efferth, Front. Pharmacol. 1, 123 (2010)
133. J.J. Magadula, P. Erasto, Nat. Prod. Rep. 26, 1535-1554 (2009)
134. P. Amoa Onguéné, F. Ntie-Kang, L.L. Lifongo, J.C. Ndom, W. Sippl, L.M. Mbaze, Malar. J. 12, 449 (2013)
