Five new mexicanolide type limonoids from Heynea trijuga

Wei YANG; Ling-Mei KONG; Shi-Fei LI; Yan LI; Yu ZHANG; Hong-Ping HE; Xiao-Jiang HAO

doi:10.1007/s13659-012-0040-1

Natural Products and Bioprospecting >

2012 , Vol. 2 >Issue 4: 145 - 149

DOI: https://doi.org/10.1007/s13659-012-0040-1

Regular Article

Five new mexicanolide type limonoids from Heynea trijuga

Wei YANG ,
Ling-Mei KONG ,
Shi-Fei LI ,
Yan LI ,
Yu ZHANG ,
Hong-Ping HE ,
Xiao-Jiang HAO

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a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
b Graduate University of Chinese Academy of Sciences, Beijing 100049, China

Received date: 2012-05-24

Revised date: 2012-06-04

Online published: 2018-02-11

Supported by

This work was financially supported by grants from the National Basic Research Program of China(973 Program, 2009CB522300 and 2009CB940900), National Natural Science Funding of China(31170332), and the Young Academic and Technical Leader Raising Foundation of Yunnan Province(2010CI047).

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Abstract

Five new mexicanolide-type limonoids, heytrijunolides A-E(1-5) were isolated from the branches and leaves of Heynea trijuga. The structures of these new compounds were elucidated on the basis of extensive spectroscopic analysis. Compound 3 showed weak cytotoxicity against HL-60, SMMC-7721 and A-549 human tumor cell lines with the IC₅₀ values of 21.88, 20.66 and 12.70 μM, respectively.

Key words： Heynea trijuga; Meliaceae; limonoids; mexicanolide-type; heytrijunolide

Cite this article

Wei YANG , Ling-Mei KONG , Shi-Fei LI , Yan LI , Yu ZHANG , Hong-Ping HE , Xiao-Jiang HAO . Five new mexicanolide type limonoids from Heynea trijuga[J]. Natural Products and Bioprospecting, 2012 , 2(4) : 145 -149 . DOI: 10.1007/s13659-012-0040-1

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