Three naphthomycin type polyketide compounds isolated from strain Streptomyces sp. HKIB0008

doi:10.1007/s13659-026-00591-6

Natural Products and Bioprospecting ›› 2026, Vol. 16 ›› Issue (3): 39-39.DOI: 10.1007/s13659-026-00591-6

• ORIGINAL ARTICLES • Previous Articles

Three naphthomycin type polyketide compounds isolated from strain Streptomyces sp. HKIB0008

Yuan Chen^1,2, Fei Zhang^1,2, Zi-Kang Zhao¹, Lin-Fang Tang¹, Yu-Xin Sun¹, Mi-Mi Tian¹, Xing-Tao Li¹, Qian Zhao^1,2, Xiao-Jiang Hao¹, Mingming Cao¹, Duozhi Chen¹

1. State Key Laboratory of Phytochemistry and Natural Medicines, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, P. R. China;
2. University of Chinese Academy of Sciences, Beijing 101408, P. R. China

Received:2025-09-30 Online:2026-06-24
Contact: Xiao-Jiang Hao,E-mail:haoxj@mail.kib.ac.cn;Mingming Cao,E-mail:caomingming@mail.kib.ac.cn;Duozhi Chen,E-mail:chenduozhi@mail.kib.ac.cn
Supported by:
This research was supported financially by grants from the Key Research and Development Project of Yunnan Province (202003AD150012, China), the National Science Foundation of China (22177050), the Xingdian Talent Support Program of Yunnan Province (XDYC-QNRC-2022-0774), Yunnan Provincial Science and Technology Department (202301AT070323), and Youth Innovation Promotion Association CAS to (2022395).

Three naphthomycin type polyketide compounds isolated from strain Streptomyces sp. HKIB0008

Yuan Chen^1,2, Fei Zhang^1,2, Zi-Kang Zhao¹, Lin-Fang Tang¹, Yu-Xin Sun¹, Mi-Mi Tian¹, Xing-Tao Li¹, Qian Zhao^1,2, Xiao-Jiang Hao¹, Mingming Cao¹, Duozhi Chen¹

1. State Key Laboratory of Phytochemistry and Natural Medicines, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, P. R. China;
2. University of Chinese Academy of Sciences, Beijing 101408, P. R. China

通讯作者: Xiao-Jiang Hao,E-mail:haoxj@mail.kib.ac.cn;Mingming Cao,E-mail:caomingming@mail.kib.ac.cn;Duozhi Chen,E-mail:chenduozhi@mail.kib.ac.cn
基金资助:
This research was supported financially by grants from the Key Research and Development Project of Yunnan Province (202003AD150012, China), the National Science Foundation of China (22177050), the Xingdian Talent Support Program of Yunnan Province (XDYC-QNRC-2022-0774), Yunnan Provincial Science and Technology Department (202301AT070323), and Youth Innovation Promotion Association CAS to (2022395).

Abstract

Abstract: Three new naphthomycin derivatives were isolated and identified from Streptomyces sp. HKIB0008, and were designated as naphthomycin R (1), naphthomycin S (2), and naphthomycin T (3). Their structures were elucidated using a combination of spectroscopic techniques, including high-resolution mass spectrometry, and NMR. The naphthoquinone core of 1 underwent carbon-carbon bond cleavage, resulting in a novel structural feature, and a corresponding Baeyer-Villiger oxidation mechanism was proposed. Compounds 2 and 3 possess a complex side chain when compared to known cystine modification on the naphthalenoid core as in the case of naphthomycins I and J. In addition, the minimum inhibitory concentration (MIC) assays for these compounds were conducted.

Key words: Naphthomycin, Streptomyces, Baeyer-Villiger oxidation, Biosynthesis

摘要： Three new naphthomycin derivatives were isolated and identified from Streptomyces sp. HKIB0008, and were designated as naphthomycin R (1), naphthomycin S (2), and naphthomycin T (3). Their structures were elucidated using a combination of spectroscopic techniques, including high-resolution mass spectrometry, and NMR. The naphthoquinone core of 1 underwent carbon-carbon bond cleavage, resulting in a novel structural feature, and a corresponding Baeyer-Villiger oxidation mechanism was proposed. Compounds 2 and 3 possess a complex side chain when compared to known cystine modification on the naphthalenoid core as in the case of naphthomycins I and J. In addition, the minimum inhibitory concentration (MIC) assays for these compounds were conducted.

关键词: Naphthomycin, Streptomyces, Baeyer-Villiger oxidation, Biosynthesis

Yuan Chen, Fei Zhang, Zi-Kang Zhao, Lin-Fang Tang, Yu-Xin Sun, Mi-Mi Tian, Xing-Tao Li, Qian Zhao, Xiao-Jiang Hao, Mingming Cao, Duozhi Chen. Three naphthomycin type polyketide compounds isolated from strain Streptomyces sp. HKIB0008[J]. Natural Products and Bioprospecting, 2026, 16(3): 39-39.

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Three naphthomycin type polyketide compounds isolated from strain Streptomyces sp. HKIB0008

Three naphthomycin type polyketide compounds isolated from strain Streptomyces sp. HKIB0008

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