Phthalide mono- and dimers from the rhizomes of Angelica sinensis and their anti-inflammatory activities

doi:10.1007/s13659-025-00512-z

Natural Products and Bioprospecting ›› 2025, Vol. 15 ›› Issue (3): 26-26.DOI: 10.1007/s13659-025-00512-z

• ORIGINAL ARTICLES • Previous Articles Next Articles

Phthalide mono- and dimers from the rhizomes of Angelica sinensis and their anti-inflammatory activities

Hongyan Wen^1,2, Sheng Li², Yu Zhang²

1. College of Ethnic Medicine, Yunnan University of Chinese Medicine, Kunming, 650500, China;
2. State Key Laboratory of Phytochemistry and Natural Medicines, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, China

Received:2025-02-10 Accepted:2025-04-06 Online:2025-06-18 Published:2025-06-24
Supported by:
This work was financially supported by National Key R&D Program of China (2022YFF1100301), Major Science and Technology Project of Henan Province (231100310200), Yunnan Province Science and Technology Department (202305AH340005).

Phthalide mono- and dimers from the rhizomes of Angelica sinensis and their anti-inflammatory activities

Hongyan Wen^1,2, Sheng Li², Yu Zhang²

1. College of Ethnic Medicine, Yunnan University of Chinese Medicine, Kunming, 650500, China;
2. State Key Laboratory of Phytochemistry and Natural Medicines, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, China

通讯作者: Yu Zhang Email:E-mail:zhangyu@mail.kib.ac.cn
基金资助:
This work was financially supported by National Key R&D Program of China (2022YFF1100301), Major Science and Technology Project of Henan Province (231100310200), Yunnan Province Science and Technology Department (202305AH340005).

Abstract

Abstract: Three pairs of enantiomeric phthalide dimers, including two new ones, angesicolides A (1) and B (2), and a new phthalide monomer (3), were obtained from the rhizomes of Angelica sinensis. Their structures were established through spectroscopic methods, quantum calculations, and chiral HPLC analysis. Compounds 1 and 2 were [2+2] and [4+2] cycloadducts of phthalide monomers, and their hypothetical biogenetic origin was proposed. Compounds 2, (+)-2, (-)-2, 4, (+)-4, and (-)-4 exhibited significant inhibitory activity against NO production with IC₅₀ values range from 1.23 to 5.55 μM.

Key words: Angelica sinensis, Phthalide dimers, Angesicolides A and B, Anti-inflammatory activity

摘要： Three pairs of enantiomeric phthalide dimers, including two new ones, angesicolides A (1) and B (2), and a new phthalide monomer (3), were obtained from the rhizomes of Angelica sinensis. Their structures were established through spectroscopic methods, quantum calculations, and chiral HPLC analysis. Compounds 1 and 2 were [2+2] and [4+2] cycloadducts of phthalide monomers, and their hypothetical biogenetic origin was proposed. Compounds 2, (+)-2, (-)-2, 4, (+)-4, and (-)-4 exhibited significant inhibitory activity against NO production with IC₅₀ values range from 1.23 to 5.55 μM.

关键词: Angelica sinensis, Phthalide dimers, Angesicolides A and B, Anti-inflammatory activity

Hongyan Wen, Sheng Li, Yu Zhang. Phthalide mono- and dimers from the rhizomes of Angelica sinensis and their anti-inflammatory activities[J]. Natural Products and Bioprospecting, 2025, 15(3): 26-26.

Hongyan Wen, Sheng Li, Yu Zhang. Phthalide mono- and dimers from the rhizomes of Angelica sinensis and their anti-inflammatory activities[J]. 应用天然产物, 2025, 15(3): 26-26.

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Phthalide mono- and dimers from the rhizomes of Angelica sinensis and their anti-inflammatory activities

Phthalide mono- and dimers from the rhizomes of Angelica sinensis and their anti-inflammatory activities

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