Carascynol A, a hybrid of caryophyllane-type terpenoid and a C6 unit degraded by polyprenylated acylphloroglucinols from Hypericum ascyron

doi:10.1007/s13659-022-00362-z

Natural Products and Bioprospecting ›› 2022, Vol. 12 ›› Issue (6): 38-38.DOI: 10.1007/s13659-022-00362-z

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Carascynol A, a hybrid of caryophyllane-type terpenoid and a C₆ unit degraded by polyprenylated acylphloroglucinols from Hypericum ascyron

Ya-Li Hu^1,2, Xing-Ren Li¹, Gang Xu¹

1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, Yunnan, People's Republic of China;
2 University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China

Received:2022-10-16 Online:2022-12-23 Published:2022-12-24
Contact: Gang Xu, E-mail: xugang008@mail.kib.ac.cn
Supported by:
This work was fnancially supported by the NSFC-Joint Foundation of Yunnan Province (Grant No. U1902213) the Second Tibetan Plateau Scientifc Expedition and Research (STEP) program (Grant No. 2019QZKK0502-0303), Natural Science Foundation of Yunnan (Grant No. 2019FA003), CAS Interdisciplinary Innovation Team of CAS “Light of West China” Program, and the Fund of State Key Laboratory of Phytochemistry and Plant Resources in West China (Grant No. E0230211Z1).

Carascynol A, a hybrid of caryophyllane-type terpenoid and a C₆ unit degraded by polyprenylated acylphloroglucinols from Hypericum ascyron

Ya-Li Hu^1,2, Xing-Ren Li¹, Gang Xu¹

1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, Yunnan, People's Republic of China;
2 University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China

通讯作者: Gang Xu, E-mail: xugang008@mail.kib.ac.cn
基金资助:
This work was fnancially supported by the NSFC-Joint Foundation of Yunnan Province (Grant No. U1902213) the Second Tibetan Plateau Scientifc Expedition and Research (STEP) program (Grant No. 2019QZKK0502-0303), Natural Science Foundation of Yunnan (Grant No. 2019FA003), CAS Interdisciplinary Innovation Team of CAS “Light of West China” Program, and the Fund of State Key Laboratory of Phytochemistry and Plant Resources in West China (Grant No. E0230211Z1).

Abstract

Abstract: Carascynol A, an unprecedented 4/9/8 ring system hybrid with a peroxide bridge, was characterized from Hypericum ascyron. The architecture contains a caryophyllane-type moiety and a C₆ unit derived from polyprenylated acylphloroglucinols. Its structure and absolute configuration were determined by comprehensive spectroscopic and X-ray difraction data. Biologically, compound 1 inhibited cell proliferation in LoVo, SW480, and HCT116 cell lines (IC₅₀= 12.30-24.57 μM).

Key words: Hypericum ascyron, Caryophyllane, Polyprenylated acylphloroglucinols, Cytotoxicity, Colon cancer

摘要： Carascynol A, an unprecedented 4/9/8 ring system hybrid with a peroxide bridge, was characterized from Hypericum ascyron. The architecture contains a caryophyllane-type moiety and a C₆ unit derived from polyprenylated acylphloroglucinols. Its structure and absolute configuration were determined by comprehensive spectroscopic and X-ray difraction data. Biologically, compound 1 inhibited cell proliferation in LoVo, SW480, and HCT116 cell lines (IC₅₀= 12.30-24.57 μM).

关键词: Hypericum ascyron, Caryophyllane, Polyprenylated acylphloroglucinols, Cytotoxicity, Colon cancer

Ya-Li Hu, Xing-Ren Li, Gang Xu. Carascynol A, a hybrid of caryophyllane-type terpenoid and a C₆ unit degraded by polyprenylated acylphloroglucinols from Hypericum ascyron[J]. Natural Products and Bioprospecting, 2022, 12(6): 38-38.

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Carascynol A, a hybrid of caryophyllane-type terpenoid and a C₆ unit degraded by polyprenylated acylphloroglucinols from Hypericum ascyron

Carascynol A, a hybrid of caryophyllane-type terpenoid and a C₆ unit degraded by polyprenylated acylphloroglucinols from Hypericum ascyron

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