Drimane sesquiterpenoids from a wetland soil-derived fungus Aspergillus calidoustus TJ403-EL05

doi:10.1007/s13659-022-00349-w

Natural Products and Bioprospecting ›› 2022, Vol. 12 ›› Issue (4): 27-27.DOI: 10.1007/s13659-022-00349-w

• Short Communication • Previous Articles

Drimane sesquiterpenoids from a wetland soil-derived fungus Aspergillus calidoustus TJ403-EL05

Sitian Zhang, Shuyuan Mo, Fengli Li, Yaxin Zhang, Jianping Wang, Zhengxi Hu, Yonghui Zhang

Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China

Received:2022-04-20 Online:2022-08-12 Published:2022-08-24
Contact: Zhengxi Hu,E-mail:hzx616@126.com;Yonghui Zhang,E-mail:zhangyh@mails.tjmu.edu.cn
Supported by:
This project was supported financially by the National Natural Science Foundation for Distinguished Young Scholars (No. 81725021), the National Natural Science Foundation of China (Nos. 81573316 and 31870326), the Innovative Research Groups of the National Natural Science Foundation of China (No. 81721005), the Fundamental Research Funds for the Central Universities (No. 2020kfyXJJS083), the National Key R&D Program of China (No. 2021YFA0910500), the Research and Development Program of Hubei Province (No. 2020BCA058), and the Chinese Medicine Research Foundation of Health Commission of Hubei Province (No. ZY2021Z019).

Drimane sesquiterpenoids from a wetland soil-derived fungus Aspergillus calidoustus TJ403-EL05

Sitian Zhang, Shuyuan Mo, Fengli Li, Yaxin Zhang, Jianping Wang, Zhengxi Hu, Yonghui Zhang

Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China

通讯作者: Zhengxi Hu,E-mail:hzx616@126.com;Yonghui Zhang,E-mail:zhangyh@mails.tjmu.edu.cn
基金资助:
This project was supported financially by the National Natural Science Foundation for Distinguished Young Scholars (No. 81725021), the National Natural Science Foundation of China (Nos. 81573316 and 31870326), the Innovative Research Groups of the National Natural Science Foundation of China (No. 81721005), the Fundamental Research Funds for the Central Universities (No. 2020kfyXJJS083), the National Key R&D Program of China (No. 2021YFA0910500), the Research and Development Program of Hubei Province (No. 2020BCA058), and the Chinese Medicine Research Foundation of Health Commission of Hubei Province (No. ZY2021Z019).

Abstract

Abstract: Soil-derived fungi represent an insufficiently tapped reservoir for discovering new and bioactive natural products (NPs), and despite an ever-increasing number of unknown NPs have been discovered over the past few decades, much of the hidden biosynthetic potential is still in an urgent need to be disclosed. In this research, a chemical investigation was performed on a wetland soil-derived fungus Aspergillus calidoustus TJ403-EL05, leading to the isolation of a total of fourteen drimane sesquiterpenoids (1-14), incorporating three new ones, namely ustusols F-H (1-3). Their structures, comprising absolute configurations, were completely authenticated by widespread spectroscopic data, quantum chemical ¹³C NMR and ECD calculations, and X-ray crystallography experiments. Compound 14 exhibited moderate anti-inflammatory activity by inhibiting the LPS-induced NO release (IC₅₀=25.6 μM).

Key words: Aspergillus calidoustus, Drimane sesquiterpenoids, Structure elucidation, Anti-inflammatory activity

摘要： Soil-derived fungi represent an insufficiently tapped reservoir for discovering new and bioactive natural products (NPs), and despite an ever-increasing number of unknown NPs have been discovered over the past few decades, much of the hidden biosynthetic potential is still in an urgent need to be disclosed. In this research, a chemical investigation was performed on a wetland soil-derived fungus Aspergillus calidoustus TJ403-EL05, leading to the isolation of a total of fourteen drimane sesquiterpenoids (1-14), incorporating three new ones, namely ustusols F-H (1-3). Their structures, comprising absolute configurations, were completely authenticated by widespread spectroscopic data, quantum chemical ¹³C NMR and ECD calculations, and X-ray crystallography experiments. Compound 14 exhibited moderate anti-inflammatory activity by inhibiting the LPS-induced NO release (IC₅₀=25.6 μM).

关键词: Aspergillus calidoustus, Drimane sesquiterpenoids, Structure elucidation, Anti-inflammatory activity

Sitian Zhang, Shuyuan Mo, Fengli Li, Yaxin Zhang, Jianping Wang, Zhengxi Hu, Yonghui Zhang. Drimane sesquiterpenoids from a wetland soil-derived fungus Aspergillus calidoustus TJ403-EL05[J]. Natural Products and Bioprospecting, 2022, 12(4): 27-27.

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Drimane sesquiterpenoids from a wetland soil-derived fungus Aspergillus calidoustus TJ403-EL05

Drimane sesquiterpenoids from a wetland soil-derived fungus Aspergillus calidoustus TJ403-EL05

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