Clerodane-type Diterpene Glycosides from Dicranopteris pedata

doi:10.1007/s13659-021-00315-y

Natural Products and Bioprospecting ›› 2021, Vol. 11 ›› Issue (5): 557-564.DOI: 10.1007/s13659-021-00315-y

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Clerodane-type Diterpene Glycosides from Dicranopteris pedata

Bei-Bei Gao², Yu-Fei Ou^1,2, Qin-Feng Zhu³, Zhi-Ping Zhou^1,2, Zhen-Tao Deng^1,2, Meng Li^1,2, Qin-Shi Zhao²

1 Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Yunnan, 650091 Kunming, People's Republic of China;
2 State Key Laboratory of Phytochemistry and Plant Resources in West China and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
3 College of Pharmacy, Guizhou Medical University, Guian New Area, Guizhou 550025, China

Received:2021-04-22 Online:2021-09-27 Published:2021-10-24
Contact: Qin-Shi Zhao
Supported by:
This work is supported by the Natural Science Foundation of Yunnan province. (No. 202001AT070052)

Clerodane-type Diterpene Glycosides from Dicranopteris pedata

Bei-Bei Gao², Yu-Fei Ou^1,2, Qin-Feng Zhu³, Zhi-Ping Zhou^1,2, Zhen-Tao Deng^1,2, Meng Li^1,2, Qin-Shi Zhao²

1 Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Yunnan, 650091 Kunming, People's Republic of China;
2 State Key Laboratory of Phytochemistry and Plant Resources in West China and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
3 College of Pharmacy, Guizhou Medical University, Guian New Area, Guizhou 550025, China

通讯作者: Qin-Shi Zhao
基金资助:
This work is supported by the Natural Science Foundation of Yunnan province. (No. 202001AT070052)

Abstract

Abstract: Three new clerodane-type diterpene glycosides, (5R,6S,8R,9S,10R)-6-O-[β-D-glucopyranosyl-(1→4)-α-L-rhamnopyranosyl] cleroda-3,13(16),14-diene (1), (5R,6S,8R,9S,10R,13S)-6-O-[β-D-glucopyranosyl-(1→ 4)-α-L-rhamnopyranosyl]-2-oxoneocleroda-3,13-dien-15-ol (2), (5R,6S,8R,9S,10R)-6-O-[β-D-glucopyranosyl-(1→ 4)-α-L-rhamnopyranosyl]-(13E)-2-oxoneocleroda-3,14-dien-13-ol (3), together with two known compounds 4 and 5 were isolated from Dicranopteris pedata. The structures of these compounds were elucidated by detailed spectroscopic analysis, and the absolute configuration of compound 2 was determined by ECD calculations. In addition, compound 1 exhibited weak inhibitory activities against SMMC-7721, MCF-7 and SW480.

Key words: Dicranopteris pedata, Clerodane-type diterpene glycosides, ECD

摘要： Three new clerodane-type diterpene glycosides, (5R,6S,8R,9S,10R)-6-O-[β-D-glucopyranosyl-(1→4)-α-L-rhamnopyranosyl] cleroda-3,13(16),14-diene (1), (5R,6S,8R,9S,10R,13S)-6-O-[β-D-glucopyranosyl-(1→ 4)-α-L-rhamnopyranosyl]-2-oxoneocleroda-3,13-dien-15-ol (2), (5R,6S,8R,9S,10R)-6-O-[β-D-glucopyranosyl-(1→ 4)-α-L-rhamnopyranosyl]-(13E)-2-oxoneocleroda-3,14-dien-13-ol (3), together with two known compounds 4 and 5 were isolated from Dicranopteris pedata. The structures of these compounds were elucidated by detailed spectroscopic analysis, and the absolute configuration of compound 2 was determined by ECD calculations. In addition, compound 1 exhibited weak inhibitory activities against SMMC-7721, MCF-7 and SW480.

关键词: Dicranopteris pedata, Clerodane-type diterpene glycosides, ECD

Bei-Bei Gao, Yu-Fei Ou, Qin-Feng Zhu, Zhi-Ping Zhou, Zhen-Tao Deng, Meng Li, Qin-Shi Zhao. Clerodane-type Diterpene Glycosides from Dicranopteris pedata[J]. Natural Products and Bioprospecting, 2021, 11(5): 557-564.

Bei-Bei Gao, Yu-Fei Ou, Qin-Feng Zhu, Zhi-Ping Zhou, Zhen-Tao Deng, Meng Li, Qin-Shi Zhao. Clerodane-type Diterpene Glycosides from Dicranopteris pedata[J]. 应用天然产物, 2021, 11(5): 557-564.

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Clerodane-type Diterpene Glycosides from Dicranopteris pedata

Clerodane-type Diterpene Glycosides from Dicranopteris pedata

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