Integrative Biology Journals
Natural Products and Bioprospecting

Natural Products and Bioprospecting ›› 2012, Vol. 2 ›› Issue (4): 138-144.DOI: 10.1007/s13659-011-0044-2

• Regular Article •     Next Articles

Cucurbitane triterpenoids from Hemsleya penxianensis

Jian-Chao CHENa, Lin ZHOUa, Yun-Hua WANGb, Ren-Rong TIANb, Yun-Xin YANa, Yin NIANa, Yun SUNa, Yong-Tang ZHENGb, Ming-Hua QIUa   

  1. a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
    b Laboratory of Molecular Immunopharmacology, Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China
  • Received:2011-12-03 Revised:2012-05-09 Online:2018-02-11 Published:2012-08-24
  • Supported by:
    This work was financially supported by the Natural Science Foundation of Yunnan Province(2008CD158), the Western Doctoral Foundation of Chinese Academy of Sciences(J. C. Chen), the Foundation of State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences(P2008ZZ23, P2010ZZ14), and the Cooperative Project of Guangdong Province and CAS(2009B091300135).

Cucurbitane triterpenoids from Hemsleya penxianensis

Jian-Chao CHENa, Lin ZHOUa, Yun-Hua WANGb, Ren-Rong TIANb, Yun-Xin YANa, Yin NIANa, Yun SUNa, Yong-Tang ZHENGb, Ming-Hua QIUa   

  1. a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
    b Laboratory of Molecular Immunopharmacology, Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China
  • 通讯作者: Ming-Hua QIU,E-mail:mhchiu@mail.kib.ac.cn
  • 基金资助:
    This work was financially supported by the Natural Science Foundation of Yunnan Province(2008CD158), the Western Doctoral Foundation of Chinese Academy of Sciences(J. C. Chen), the Foundation of State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences(P2008ZZ23, P2010ZZ14), and the Cooperative Project of Guangdong Province and CAS(2009B091300135).

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Abstract: Two new cucurbitacins, jinfushanencins A(1) and B(2), seven new cucurbitane glycosides, jinfushanosides E-K(3-9), along with nine known analogues, were obtained from the tubers of Hemsleya penxianensis. Their structures were elucidated on the basis of extensive spectroscopic and chemical methods. Selected isolates were tested their anti-HIV-1 activities, and compound 5 showed weak anti-HIV-1 in C8166 cell(EC50=5.9 μg/mL) with a selectivity index of 13.5.

Key words: cucurbitane triterpenoid, jinfushanencin, jinfushanoside, Hemsleya penxianensis

摘要： Two new cucurbitacins, jinfushanencins A(1) and B(2), seven new cucurbitane glycosides, jinfushanosides E-K(3-9), along with nine known analogues, were obtained from the tubers of Hemsleya penxianensis. Their structures were elucidated on the basis of extensive spectroscopic and chemical methods. Selected isolates were tested their anti-HIV-1 activities, and compound 5 showed weak anti-HIV-1 in C8166 cell(EC50=5.9 μg/mL) with a selectivity index of 13.5.

关键词: cucurbitane triterpenoid, jinfushanencin, jinfushanoside, Hemsleya penxianensis

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