Two New Indolyl Diketopiperazines, Trypostatins C and D from Aspergillus penicilliodes Speg.

doi:10.1007/s13659-018-0156-z

Natural Products and Bioprospecting ›› 2018, Vol. 8 ›› Issue (2): 107-111.DOI: 10.1007/s13659-018-0156-z

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Two New Indolyl Diketopiperazines, Trypostatins C and D from Aspergillus penicilliodes Speg.

Han Zhang^1,2, Hong-Tao Zhu¹, Dong Wang¹, Chong-Ren Yang¹, Ying-Jun Zhang^1,3

1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
2 University of Chinese Academy of Sciences, Beijing 100049, China;
3 Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China

Received:2018-01-28 Revised:2018-03-01 Online:2018-04-26 Published:2018-04-24
Contact: Ying-Jun Zhang
Supported by:
This work was supported by the National Natural Science Foundation of China (No. 21672223). The authors are grateful to the staffs of the analytical and bioactivity screening groups at State Key Laboratory of Phytochemistry and Plant Resources in West China, KIB, CAS, for measuring the spectroscopic data and bioactivities.

Two New Indolyl Diketopiperazines, Trypostatins C and D from Aspergillus penicilliodes Speg.

Han Zhang^1,2, Hong-Tao Zhu¹, Dong Wang¹, Chong-Ren Yang¹, Ying-Jun Zhang^1,3

1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
2 University of Chinese Academy of Sciences, Beijing 100049, China;
3 Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China

通讯作者: Ying-Jun Zhang
基金资助:
This work was supported by the National Natural Science Foundation of China (No. 21672223). The authors are grateful to the staffs of the analytical and bioactivity screening groups at State Key Laboratory of Phytochemistry and Plant Resources in West China, KIB, CAS, for measuring the spectroscopic data and bioactivities.

Abstract

Abstract: Twelve indolyl diketopiperazines 1-12 were isolated from the mycelia culture of Aspergillus penicilliodes Speg., a dominant microorganism from the post fermentation process of ripe Pu-er tea. Their structures were elucidated by extensive spectroscopic methods. Among them, trypostatins C (1) and D (2) featuring with a rare methyl vinyl ketone side chain at C-2 are new compounds, while 3 and 4 were obtained for the first time from nature source. The isolates 3-12 did not show obvious cytotoxicities against five human cancer cell lines at a concentration of 40 μM.

Key words: Aspergillus penicilliodes Speg., Indolyl diketopiperazines, Trypostatins

摘要： Twelve indolyl diketopiperazines 1-12 were isolated from the mycelia culture of Aspergillus penicilliodes Speg., a dominant microorganism from the post fermentation process of ripe Pu-er tea. Their structures were elucidated by extensive spectroscopic methods. Among them, trypostatins C (1) and D (2) featuring with a rare methyl vinyl ketone side chain at C-2 are new compounds, while 3 and 4 were obtained for the first time from nature source. The isolates 3-12 did not show obvious cytotoxicities against five human cancer cell lines at a concentration of 40 μM.

关键词: Aspergillus penicilliodes Speg., Indolyl diketopiperazines, Trypostatins

Han Zhang, Hong-Tao Zhu, Dong Wang, Chong-Ren Yang, Ying-Jun Zhang. Two New Indolyl Diketopiperazines, Trypostatins C and D from Aspergillus penicilliodes Speg.[J]. Natural Products and Bioprospecting, 2018, 8(2): 107-111.

Han Zhang, Hong-Tao Zhu, Dong Wang, Chong-Ren Yang, Ying-Jun Zhang. Two New Indolyl Diketopiperazines, Trypostatins C and D from Aspergillus penicilliodes Speg.[J]. 应用天然产物, 2018, 8(2): 107-111.

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Two New Indolyl Diketopiperazines, Trypostatins C and D from Aspergillus penicilliodes Speg.

Two New Indolyl Diketopiperazines, Trypostatins C and D from Aspergillus penicilliodes Speg.

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